公开(公告)号：US20070041904A1

公开(公告)日：2007-02-22

申请号：US11437095

申请日：2006-05-19

申请人： Tao Jiang ,  Emilia Olsen ,  Michael Whitney ,  Todd Aguilera ,  Quyen Nguyen ,  Edmund Wong ,  Roger Tsien

发明人： Tao Jiang ,  Emilia Olsen ,  Michael Whitney ,  Todd Aguilera ,  Quyen Nguyen ,  Edmund Wong ,  Roger Tsien

IPC分类号： A61K51/00 ,  A61K49/10 ,  C07K7/64 ,  C12N15/86

CPC分类号： C07K7/08 ,  A61K38/00 ,  A61K41/0095 ,  A61K47/64 ,  A61K47/645 ,  A61K47/65 ,  A61K49/0032 ,  A61K49/0043 ,  A61K49/0056 ,  A61K49/085 ,  A61K49/14 ,  A61K49/146 ,  A61K51/088 ,  C07K14/00 ,  C07K14/4728

摘要： A generic structure for the peptides of the present invention includes A-X-B-C, where C is a cargo moiety, the B portion includes basic amino acids, X is a cleavable linker sequence, and the A portion includes acidic amino acids. The intact structure is not significantly taken up by cells; however, upon extracellular cleavage of X, the B-C portion is taken up, delivering the cargo to targeted cells. Cargo may be, for example, a contrast agent for diagnostic imaging, a chemotherapeutic drug, or a radiation-sensitizer for therapy. X may be cleaved extracellularly or intracellularly. The molecules of the present invention may be linear, cyclic, branched, or have a mixed structure.

摘要翻译： 本发明的肽的一般结构包括A-X-B-C，其中C是货物部分，B部分包括碱性氨基酸，X是可切割的接头序列，A部分包括酸性氨基酸。 完整结构不被细胞所占据; 然而，在X的细胞外裂解时，B-C部分被吸收，将货物运送到靶细胞。 货物可以是例如用于诊断成像的对比剂，化学治疗药物或用于治疗的放射线敏化剂。 X可能在细胞外或细胞内裂解。 本发明的分子可以是直链，环状，支链或具有混合结构。

公开(公告)号：US06196679B1

公开(公告)日：2001-03-06

申请号：US09224713

申请日：1998-12-31

申请人： Edmund Wong

发明人： Edmund Wong

IPC分类号： G02C900

CPC分类号： G02C9/00

摘要： An assembly enabling detachable fitting of a pair of auxiliary lenses to a pair of primary spectacles; the assembly including a pair of projections on a primary spectacle frame each having a recess or opening which each receive a corresponding projection on an auxiliary frame which holds the pair of auxiliary lenses. The arrangement is such that each projection on the auxiliary frame positively engages an opening on a corresponding projection on the primary spectacle frame.

摘要翻译： 一种能够将一对辅助透镜可拆卸地装配到一对主眼镜的组件; 所述组件包括在主眼镜架上的一对突起，每个突起具有凹部或开口，每个凹部或开口在保持所述一对辅助透镜的辅助框架上接收相应的突起。 这种布置使得辅助框架上的每个突出部肯定地接合在主眼镜框架上的相应突起上的开口。

公开(公告)号：US20100016774A1

公开(公告)日：2010-01-21

申请号：US11632803

申请日：2005-07-12

申请人： Edmund Wong

发明人： Edmund Wong

IPC分类号： A61F5/00

CPC分类号： A61F5/028 ,  A61F7/10 ,  A61F13/143 ,  A61F13/148 ,  A61N2005/0659 ,  A61N2005/067

摘要： A apparatus for treatment of acute or chronic pain comprising a pain relief treatment device applicable to a soft tissue injury at the periosteal-osseous boundary, and a device for immobilization of the area of soft tissue injury after application of the treatment device. Pain treatment may comprise injection of anti-inflammatory agent, including but not limited to steroids, and/or anesthetics; or low power laser irradiation, or cold treatment to the area of soft tissue injury. Immobilization devices for the cervical and lumbar vertebrae are provided for promoting healing of treated soft tissue injury sites. The invention includes a packaged set of materials comprising a pain relief treatment device, and an external supportive device for immobilizing the soft tissue injury at the site of treatment.

摘要翻译： 一种用于治疗急性或慢性疼痛的装置，包括适用于骨膜 - 骨骼边界的软组织损伤的止痛治疗装置，以及在施用治疗装置之后固定软组织损伤区域的装置。 疼痛治疗可以包括注射抗炎剂，包括但不限于类固醇和/或麻醉剂; 或低功率激光照射，或冷处理到软组织损伤区域。 用于颈椎和腰椎的固定装置用于促进治疗的软组织损伤部位的愈合。 本发明包括一组包括疼痛缓解治疗装置的材料，以及用于在治疗部位固定软组织损伤的外部支撑装置。

公开(公告)号：USD682287S1

公开(公告)日：2013-05-14

申请号：US29375514

申请日：2010-09-23

申请人： Xinri Cong ,  Thomas L. Hampton ,  Carl Stevens ,  Michael Vock ,  Edmund Wong

设计人： Xinri Cong ,  Thomas L. Hampton ,  Carl Stevens ,  Michael Vock ,  Edmund Wong

公开(公告)号：US5640978A

公开(公告)日：1997-06-24

申请号：US788604

申请日：1991-11-06

申请人： Edmund Wong

发明人： Edmund Wong

IPC分类号： A61N5/06 ,  A61N5/067 ,  A24B3/12

CPC分类号： A61N5/0619 ,  A61N2005/0659 ,  A61N2005/067

摘要： The invention comprises a method for treatment of chronic and referred pain such as chronic headaches and migraine headaches, as well as pain of the upper back, neck and shoulders, and lower back pain using low power laser light. The source of such referred pain involves microscopic and macroscopic tears in the periosteal-osseous junctions of the upper vertebrae, the scapula, and the skull. These lesions stimulate the generation of histamines, kinins, bradykinins, prostaglandin, proteolytic enzymes, seratonin, and other substances which cause numerous localized autonomic reactions, such as muscle spasm, ischemia, local inflammation, edema, as well as generalized reactions such as increased blood pressure, photophobia, nausea, blurred vision, copious mucous flow of the nose and sinus, and the like. The muscle spasms are responsible for transmitting the pain sensation to other portions of the body, and the systemic reactions are often associated with migraine-type headaches. The sites of the periosteal-osseous lesions can be correlated directly with the distant locus of the referred pain sensation. The laser energy is directed to the sites of the lesions to cause an increase in lymphatic circulation at the site of the causative lesion in response to the laser energy. Laser energy delivered to the site results in increased blood circulation and cellular metabolism in the area, which promotes more rapid healing of the lesion.

摘要翻译： 本发明包括使用低功率激光治疗慢性和疼痛的方法，例如慢性头痛和偏头痛，以及上背部，颈部和肩部的疼痛以及腰痛。 这种所谓疼痛的根源涉及上椎骨，肩胛骨和颅骨的骨膜 - 骨连接处的微观和宏观撕裂。 这些病变刺激组胺，激肽，缓激肽，前列腺素，蛋白水解酶，血清素和其它引起多种局部自主反应的物质的产生，如肌肉痉挛，局部缺血，局部炎症，水肿，以及广泛的反应如血液增多 压力，畏光，恶心，视力模糊，鼻窦粘液流淌等。 肌肉痉挛负责将疼痛感觉传递到身体的其他部分，并且全身反应通常与偏头痛型头痛相关。 骨膜 - 骨性病变的部位可以直接与所述疼痛感觉的远处相关联。 激光能量被引导到损伤部位以响应于激光能量引起病变部位的淋巴循环增加。 传递到该部位的激光能量导致该区域的血液循环和细胞新陈代谢增加，这促进了病变的愈合愈合。

公开(公告)号：US6125111A

公开(公告)日：2000-09-26

申请号：US721095

申请日：1996-09-27

申请人： Harold J. Snow ,  Edmund Wong ,  Anatoly Tarsky ,  Bruce I. Barkhouse

发明人： Harold J. Snow ,  Edmund Wong ,  Anatoly Tarsky ,  Bruce I. Barkhouse

IPC分类号： H04J3/00 ,  H04J3/16 ,  H04Q3/545 ,  H04Q11/04 ,  H04J3/02

CPC分类号： H04Q3/54558 ,  H04J3/1611 ,  H04Q3/5455

摘要： An architecture for a modular communications system is disclosed. The modular communications system comprises at least one control module; a plurality of resource modules for receipt of external payload data provided to said system or for manipulation of the payload data; a plurality of resource module links, one link connecting each resource module to the control module and each resource module. The control module comprises a switch for switching payload data between the plurality of resource modules; and a bandwidth allocator comprising a bandwidth selector and a distributor each connected to the switch and to the resource module links. The bandwidth selector allows the selection of the bandwidth of payload data passed from any of the resource modules to the time switch. Similarly, the bandwidth distributor allows for the selection of the bandwidth of payload data switched through the switch and provided to any of the resource modules from the control module. Preferably, all the resource module links are electrically isolated from each other. The architecture provides for the modular assembly of a telecommunications offering varied capacities, redundancies and services.

摘要翻译： 公开了一种用于模块化通信系统的架构。 模块化通信系统包括至少一个控制模块; 用于接收提供给所述系统的外部有效载荷数据或用于操纵有效载荷数据的多个资源模块; 多个资源模块链路，将每个资源模块连接到控制模块和每个资源模块的一个链路。 所述控制模块包括用于在所述多个资源模块之间切换有效载荷数据的开关; 以及带宽分配器，其包括带宽选择器和分配器，每个连接到交换机和资源模块链路。 带宽选择器允许选择从任何资源模块传递到时间切换的有效载荷数据的带宽。 类似地，带宽分配器允许选择通过交换机切换的有效载荷数据的带宽，并且提供给来自控制模块的任何资源模块。 优选地，所有资源模块链路彼此电隔离。 该架构提供了提供不同容量，冗余和服务的电信的模块化组装。