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公开(公告)号：US20080293939A1
公开(公告)日：2008-11-27
申请号：US11950079
申请日：2007-12-04
IPC分类号： C07D239/88
CPC分类号： C07D403/14 , C07C229/56 , C07D239/90 , C07D239/95 , C07D405/04 , C07D405/14 , C07D413/04
摘要： The present invention relates to quinazolinones of formula (I) wherein R1 is hal; a); b); or c); X is N or CR8; R2 is hal; nitro; C1-C6alkylcarbonyl; C1-C6alkyl or C3-C6cycloalkyl; R3 is C1-C6alkyl; C1-C6alkoxy or amino; and wherein the further radicals have the meanings as defined in the specification, which compounds exhibit human vanilloid antagonistic activity; to processes for their production, their use as pharmaceuticals and to pharmaceutical compositions comprising them.
摘要翻译： 本发明涉及式（I）的喹唑啉酮，其中R 1为卤素; 一个）; b）; 或c）; X为N或CR8; R2是hal; 硝基 C1-C6烷基羰基; C 1 -C 6烷基或C 3 -C 6环烷基; R3是C1-C6烷基; C1-C6烷氧基或氨基; 并且其中所述其它基团具有如说明书中所定义的含义，所述化合物表现出人类香草素拮抗活性; 其制备方法，它们作为药物的用途以及包含它们的药物组合物。
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公开(公告)号：US08211902B2
公开(公告)日：2012-07-03
申请号：US13089943
申请日：2011-04-19
申请人： Timothy John Ritchie , Andrew James Culshaw , Christopher Thomas Brain , Edward Karol Dziadulewicz , Terance William Hart
发明人： Timothy John Ritchie , Andrew James Culshaw , Christopher Thomas Brain , Edward Karol Dziadulewicz , Terance William Hart
IPC分类号： A61K31/517
CPC分类号： C07D401/04 , C07D239/91
摘要： The present invention relates to the use of a quinazolinone compound of the formula (I) wherein R1, R2, R3, R4, R5 and m are as defined in the specification and in the claims, in free form or in salt form, and, where possible, in acid addition salt form, as a vanilloid.
摘要翻译： 本发明涉及式（I）的喹唑啉酮化合物，其中R 1，R 2，R 3，R 4，R 5和m如说明书和权利要求中所定义，为游离形式或盐形式， 在可能的情况下，以酸加成盐形式，作为香草素。
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公开(公告)号：US20090082365A1
公开(公告)日：2009-03-26
申请号：US12095995
申请日：2006-12-06
申请人： Gurdip Bhalay , Andrew James Culshaw , Edward Karol Dziadulewicz , Christopher Thomas Brain , Timothy John Ritchie , David Beattie , Kamlesh Jagdis Bala , Alice Brewer , Glyn Hughes
发明人： Gurdip Bhalay , Andrew James Culshaw , Edward Karol Dziadulewicz , Christopher Thomas Brain , Timothy John Ritchie , David Beattie , Kamlesh Jagdis Bala , Alice Brewer , Glyn Hughes
IPC分类号： A61K31/517 , C07D239/90 , C07D401/04 , C07D403/04
CPC分类号： C07D239/95 , C07D239/91 , C07D401/04 , C07D403/04
摘要： The present invention relates to quinazolinone compounds of the formula wherein R2, R3, R5, R6, R7 and R8 are as defined in the specification and in the claims, in free form or in salt form, processes for their preparation and their use as pharmaceuticals, particularly in the treatment of disorders ameliorated by administration of TRPV1 antagonists.
摘要翻译： 本发明涉及下式的喹唑啉酮化合物，其中R2，R3，R5，R6，R7和R8如说明书和权利要求中所定义，以游离形式或盐形式，其制备方法及其作为药物的用途 特别是在通过施用TRPV1拮抗剂而改善的疾病的治疗中。
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4.发明申请公开(公告)号：US20110195983A1
公开(公告)日：2011-08-11
申请号：US13089943
申请日：2011-04-19
申请人： Timothy John Ritchie , Andrew James Culshaw , Christopher Thomas Brain , Edward Karol Dziadulewicz , Terance William Hart
发明人： Timothy John Ritchie , Andrew James Culshaw , Christopher Thomas Brain , Edward Karol Dziadulewicz , Terance William Hart
IPC分类号： A61K31/517 , C07D239/91 , C07D401/04 , A61P25/04 , A61P29/00
CPC分类号： C07D401/04 , C07D239/91
摘要： The present invention relates to the use of a quinazolinone compound of the formula (I) wherein R1, R2, R3, R4, R5 and m are as defined in the specification and in the claims, in free form or in salt form, and, where possible, in acid addition salt form, as a vanilloid.
摘要翻译： 本发明涉及式（I）的喹唑啉酮化合物，其中R 1，R 2，R 3，R 4，R 5和m如说明书和权利要求中所定义，为游离形式或盐形式， 在可能的情况下，以酸加成盐形式，作为香草素。
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公开(公告)号：US20080318940A1
公开(公告)日：2008-12-25
申请号：US12096139
申请日：2006-12-06
申请人： Edward Karol Dziadulewicz , Christopher Thomas Brain , Timothy John Ritchie , Andrew James Culshaw
发明人： Edward Karol Dziadulewicz , Christopher Thomas Brain , Timothy John Ritchie , Andrew James Culshaw
IPC分类号： A61K31/5383 , C07D239/88 , A61K31/517 , A61P25/04 , C07D487/04 , C07D498/04 , C07D471/04
CPC分类号： C07D471/04 , C07D487/04
摘要： The invention relates to quinazolinone compounds of the formula wherein the R groups are defined in the specification, processes for their preparation and their use as pharmaceuticals, particularly in the treatment of disorders ameliorated by administration of TRPV1 antagonists.
摘要翻译： 本发明涉及下式的喹唑啉酮化合物，其中R基团在说明书中定义，其制备方法及其作为药物的用途，特别是治疗通过施用TRPV1拮抗剂而改善的疾病。
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公开(公告)号：US20080312316A1
公开(公告)日：2008-12-18
申请号：US12096244
申请日：2006-12-05
申请人： Andrew James Culshaw , Christopher Thomas Brain , Edward Karol Dziadulewicz , Lee Edwards , Terance William Hart , Timothy John Ritchie
发明人： Andrew James Culshaw , Christopher Thomas Brain , Edward Karol Dziadulewicz , Lee Edwards , Terance William Hart , Timothy John Ritchie
IPC分类号： A61K31/352 , C07D311/22
CPC分类号： C07D491/04
摘要： The invention relates to novel heterocyclic compounds of the formula in which all of the variables are as defined in the specification, in free form or in salt form, to their preparation, to their use as medicaments and to medicaments comprising them.
摘要翻译： 本发明涉及下式的新型杂环化合物，其中所有变量如本说明书中所定义，以游离形式或盐形式，其制备方式，其用作药物和包含它们的药物。
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公开(公告)号：US20080194595A1
公开(公告)日：2008-08-14
申请号：US11569802
申请日：2005-06-08
申请人： Timothy John Ritchie , Andrew James Culshaw , Christopher Thomas Brain , Edward Karol Dziadulewicz , Terance William Hart
发明人： Timothy John Ritchie , Andrew James Culshaw , Christopher Thomas Brain , Edward Karol Dziadulewicz , Terance William Hart
IPC分类号： A61K31/498 , C07D239/88
CPC分类号： C07D401/04 , C07D239/91
摘要： The present invention relates to the use of a quinazolinone compound of the formula (I) wherein R1, R2, R3, R4, R5 and m are as defined in the specification and in the claims, in free form or in salt form, and, where possible, in acid addition salt form, as a vanilloid.
摘要翻译： 本发明涉及式（I）的喹唑啉酮化合物的用途，其中R 1，R 2，R 3，R 3， R 5，R 5和m如说明书和权利要求中所定义，为游离形式或盐形式，并且在可能情况下为酸加成盐形式，如 香草素
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公开(公告)号：US20080114056A1
公开(公告)日：2008-05-15
申请号：US11570049
申请日：2005-06-08
申请人： Timothy John Ritchie , Andrew James Culshaw , Terance William Hart , Christopher Thomas Brain , Edward Karol Dziadulewicz
发明人： Timothy John Ritchie , Andrew James Culshaw , Terance William Hart , Christopher Thomas Brain , Edward Karol Dziadulewicz
IPC分类号： A61K31/352 , A61P25/00 , C07D311/28
CPC分类号： C07D407/04 , C07D311/36 , C07D405/12
摘要： The present invention relates to the use of a chromone compound of the formula wherein R1, R2, R3, R4, R5 and m are as defined in the specification and in the claims, in free form or in salt form, and, where possible, in acid addition salt form, as a vanilloid antagonist.
摘要翻译： 本发明涉及下式的色酮化合物的用途：其中R 1，R 2，R 3，R 4， R 5和m如说明书和权利要求书中所定义，以游离形式或盐形式，并且如果可能，以酸加成盐形式作为香草酸拮抗剂 。
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公开(公告)号：US08809528B2
公开(公告)日：2014-08-19
申请号：US13434248
申请日：2012-03-29
申请人： Timothy John Ritchie , Andrew James Culshaw , Christopher Thomas Brain , Edward Karol Dziadulewicz , Terance William Hart
发明人： Timothy John Ritchie , Andrew James Culshaw , Christopher Thomas Brain , Edward Karol Dziadulewicz , Terance William Hart
IPC分类号： C07D239/91
CPC分类号： C07D401/04 , C07D239/91
摘要： The present invention relates to the use of a quinazolinone compound of the formula (I) wherein R1, R2, R3, R4, R5 and m are as defined in the specification and in the claims, in free form or in salt form, and, where possible, in acid addition salt form, as a vanilloid.
摘要翻译： 本发明涉及式（I）的喹唑啉酮化合物，其中R 1，R 2，R 3，R 4，R 5和m如说明书和权利要求中所定义，为游离形式或盐形式， 在可能的情况下，以酸加成盐形式，作为香草素。
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10.发明申请公开(公告)号：US20120184571A1
公开(公告)日：2012-07-19
申请号：US13434248
申请日：2012-03-29
申请人： Timothy John RITCHIE , Andrew James Culshaw , Christopher Thomas Brain , Edward Karol Dziadulewicz , Terance William Hart
发明人： Timothy John RITCHIE , Andrew James Culshaw , Christopher Thomas Brain , Edward Karol Dziadulewicz , Terance William Hart
IPC分类号： A61K31/517 , A61P29/00 , A61P11/00 , A61P11/06 , A61P19/02 , A61P13/02 , A61P25/06 , A61P1/00 , A61P1/18 , A61P17/00 , C07D239/88 , A61P11/14
CPC分类号： C07D401/04 , C07D239/91
摘要： The present invention relates to the use of a quinazolinone compound of the formula (I) wherein R1, R2, R3, R4, R5 and m are as defined in the specification and in the claims, in free form or in salt form, and, where possible, in acid addition salt form, as a vanilloid.
摘要翻译： 本发明涉及式（I）的喹唑啉酮化合物，其中R 1，R 2，R 3，R 4，R 5和m如说明书和权利要求中所定义，为游离形式或盐形式， 在可能的情况下，以酸加成盐形式，作为香草素。
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