公开(公告)号：US08741581B2

公开(公告)日：2014-06-03

申请号：US13266567

申请日：2010-04-27

Applicant: Arie Admon ,  Eilon Barnea ,  Ilan Beer ,  Tamar Ziv

Inventor： Arie Admon ,  Eilon Barnea ,  Ilan Beer ,  Tamar Ziv

IPC: G01N33/53

CPC classification number: G01N33/57419 ,  A61K39/0011 ,  G01N2800/56

Abstract: The present invention relates to methods for detecting, prognosing and staging cancers, in particular cancers of the gastrointestinal tract. The methods of the invention comprise detecting specific protein markers in a tissue of interest, wherein the detected levels thereof may be indicative of pre-cancerous or cancerous tissue, or the stage or prognosis of a cancer. Further provided are methods of treating cancer, and cancer detection kits.

Abstract translation: 本发明涉及用于检测，预后和分期癌症，特别是胃肠道癌症的方法。 本发明的方法包括检测感兴趣的组织中的特异性蛋白质标记，其中检测的水平可以指示癌前或癌组织，或癌症的阶段或预后。 还提供了治疗癌症的方法和癌症检测试剂盒。

公开(公告)号：US20050053918A1

公开(公告)日：2005-03-10

申请号：US10705459

申请日：2003-11-12

Applicant: Eilon Barnea ,  Ilan Beer ,  Tamar Ziv ,  Arie Admon ,  Lior Dassau ,  Samuel Buchsbaum

Inventor： Eilon Barnea ,  Ilan Beer ,  Tamar Ziv ,  Arie Admon ,  Lior Dassau ,  Samuel Buchsbaum

IPC: A61K39/00 ,  C07K16/28 ,  G01N33/50 ,  C12Q1/70 ,  G01N33/574

CPC classification number: G01N33/502 ,  A61K39/0011 ,  C07K16/2833 ,  G01N33/5008 ,  G01N2500/00

Abstract: A method of identifying peptides originating from a particular cell type and being capable of binding to MHC molecules of a particular haplotype is disclosed. The method comprises obtaining a cell type expressing a soluble and secreted form of the MHC molecules of the particular haplotype; collecting the soluble and secreted form of the MHC molecules of the particular haplotype; and analyzing peptides bound to the soluble and secreted form of the MHC molecules of the particular haplotype, thereby identifying the peptides originating from the particular cell type and being capable of binding to MHC molecules of the particular haplotype.

Abstract translation: 公开了鉴定源自特定细胞类型并能够结合特定单体型的MHC分子的肽的方法。 该方法包括获得表达特定单元型的MHC分子的可溶性和分泌形式的细胞类型; 收集特定单体型的MHC分子的可溶和分泌形式; 并分析与特定单元型的MHC分子的可溶性和分泌形式结合的肽，从而鉴定源自特定细胞类型并能够结合特定单倍型的MHC分子的肽。

公开(公告)号：US20120039811A1

公开(公告)日：2012-02-16

申请号：US13266567

申请日：2010-04-27

Applicant: Arie Admon ,  Eilon Barnea ,  Ilan Beer ,  Tamar Ziv

Inventor： Arie Admon ,  Eilon Barnea ,  Ilan Beer ,  Tamar Ziv

IPC: G01N33/574 ,  C40B30/06 ,  C12Q1/68 ,  C12Q1/02 ,  A61K49/00

CPC classification number: G01N33/57419 ,  A61K39/0011 ,  G01N2800/56

Abstract: The present invention relates to methods for detecting, prognosing and staging cancers, in particular cancers of the gastrointestinal tract. The methods of the invention comprise detecting specific protein markers in a tissue of interest, wherein the detected levels thereof may be indicative of pre-cancerous or cancerous tissue, or the stage or prognosis of a cancer. Further provided are methods of treating cancer, and cancer detection kits.

Abstract translation: 本发明涉及用于检测，预后和分期癌症，特别是胃肠道癌症的方法。 本发明的方法包括检测感兴趣的组织中的特异性蛋白质标记，其中检测的水平可以指示癌前或癌组织，或癌症的阶段或预后。 还提供了治疗癌症的方法和癌症检测试剂盒。

公开(公告)号：US07512524B2

公开(公告)日：2009-03-31

申请号：US11084435

申请日：2005-03-18

Applicant: Ilan Be'er ,  Eilon Barnea ,  Emanuel Gofman

Inventor： Ilan Be'er ,  Eilon Barnea ,  Emanuel Gofman

IPC: G06F15/00

CPC classification number: G01N33/6848 ,  H01J49/04

Abstract: A method for preparing peptide spectra for identification, the method including constructing a symmetric distance matrix from a plurality of peptide spectra, where a cluster of at least one of the spectra is represented in a row of the matrix, and where the cluster is also represented in a column of the matrix, finding the minimum of each of the clusters in the matrix, constructing a vector from the minima where each element in the vector corresponds to one of the clusters, finding the global minimum of the matrix as being the minimum of the vector, merging two of the clusters identified by the global minimum into a merged cluster, and providing the merged cluster for identification of at least one peptide associated with the merged cluster.

Abstract translation: 一种用于制备用于鉴定的肽谱的方法，所述方法包括从多个肽谱构建对称距离矩阵，其中至少一个光谱的簇在矩阵的一行中表示，并且其中簇也被表示 在矩阵的列中，找到矩阵中每个簇的最小值，从最小值构建向量，其中向量中的每个元素对应于簇之一，将矩阵的全局最小值作为最小值 向量，将由全局最小值识别的两个集群合并成合并的集群，以及提供用于识别与合并的集群相关联的至少一个肽的合并集群。

公开(公告)号：US20060208185A1

公开(公告)日：2006-09-21

申请号：US11084435

申请日：2005-03-18

Applicant: Ilan Be'er ,  Eilon Barnea ,  Emanuel Gofman

Inventor： Ilan Be'er ,  Eilon Barnea ,  Emanuel Gofman

IPC: B01D59/44 ,  H01J49/00

CPC classification number: G01N33/6848 ,  H01J49/04

Abstract: A method for preparing peptide spectra for identification, the method including constructing a symmetric distance matrix from a plurality of peptide spectra, where a cluster of at least one of the spectra is represented in a row of the matrix, and where the cluster is also represented in a column of the matrix, finding the minimum of each of the clusters in the matrix, constructing a vector from the minima where each element in the vector corresponds to one of the clusters, finding the global minimum of the matrix as being the minimum of the vector, merging two of the clusters identified by the global minimum into a merged cluster, and providing the merged cluster for identification of at least one peptide associated with the merged cluster.

公开(公告)号：US06867283B2

公开(公告)日：2005-03-15

申请号：US09865548

申请日：2001-05-29

Applicant: Eilon Barnea ,  Ilan Beer ,  Tamar Ziv ,  Arie Admon

Inventor： Eilon Barnea ,  Ilan Beer ,  Tamar Ziv ,  Arie Admon

IPC: G01N33/569 ,  A61K38/08

CPC classification number: G01N33/56977 ,  G01N2500/00

Abstract: A method of identifying peptides originating from a particular cell type and being capable of binding to MHC molecules of a particular haplotype is disclosed. The method comprises obtaining a cell type expressing a soluble and secreted form of the MHC molecules of the particular haplotype; collecting the soluble and secreted form of the MHC molecules of the particular haplotype; and analyzing peptides bound to the soluble and secreted form of the MHC molecules of the particular haplotype, thereby identifying the peptides originating from the particular cell type and being capable of binding to MHC molecules of the particular haplotype.

Abstract translation: 公开了鉴定源自特定细胞类型并能够结合特定单体型的MHC分子的肽的方法。 该方法包括获得表达特定单元型的MHC分子的可溶性和分泌形式的细胞类型; 收集特定单体型的MHC分子的可溶和分泌形式; 并分析与特定单元型的MHC分子的可溶性和分泌形式结合的肽，从而鉴定源自特定细胞类型并能够结合特定单倍型的MHC分子的肽。