公开(公告)号：US07312058B2

公开(公告)日：2007-12-25

申请号：US10892112

申请日：2004-07-16

申请人： Tatsuki Kashiwagi ,  Yuko Kai ,  Kohki Ishikawa ,  Ei-ichiro Suzuki ,  Hiroshi Takagi ,  Mikhail Kharisovich Ziyatdinov ,  Ekaterina Igorevna Redkina ,  Mikhail Markovich Gusyatiner

发明人： Tatsuki Kashiwagi ,  Yuko Kai ,  Kohki Ishikawa ,  Ei-ichiro Suzuki ,  Hiroshi Takagi ,  Mikhail Kharisovich Ziyatdinov ,  Ekaterina Igorevna Redkina ,  Mikhail Markovich Gusyatiner

IPC分类号： C12N9/10 ,  C12N1/12 ,  C12N15/74 ,  C12P13/12 ,  C07H21/00

CPC分类号： C12P13/12 ,  C12N9/1029

摘要： O-acetylserine, L-cysteine and sulphurous compounds derived therefrom may be produced using a bacterium belonging to the genus Escherichia which harbors a mutant feedback-resistant serine acetyltransferases in which the amino acid sequence corresponding to positions from 89 to 96 in a wild-type serine acetyltransferase is replaced with any one of the amino acid sequences shown in SEQ ID NOS: 4 to 9, and feedback inhibition by L-cysteine in the bacterium is desensitized.

摘要翻译： O-乙酰丝氨酸，L-半胱氨酸和从其衍生的亚硫酸化合物可以使用属于埃希氏杆菌属的细菌产生，其含有突变反馈抗性丝氨酸乙酰转移酶，其中对应于野生型的89至96位的氨基酸序列 丝氨酸乙酰转移酶被SEQ ID NO：4至9所示的氨基酸序列中的任何一个替代，并且细菌中L-半胱氨酸的反馈抑制被脱敏。