公开(公告)号：US20100009392A1

公开(公告)日：2010-01-14

申请号：US12375074

申请日：2007-07-26

申请人： Nguyen Tan ,  Eleni Venetsanakos ,  Michel Faure ,  Carla Heise

发明人： Nguyen Tan ,  Eleni Venetsanakos ,  Michel Faure ,  Carla Heise

IPC分类号： G01N33/53

CPC分类号： A61K31/4439 ,  A61K31/44 ,  A61K31/496 ,  G01N33/5743 ,  G01N2333/4704 ,  G01N2500/10

摘要： The present invention provides a method for determining a response of a mammalian subject having melanoma tumor cells to treatment with a melanoma inhibitory agent. In one aspect, the method comprises (a) determining a first concentration of melanoma inhibitory activity protein (MIA) in a first biological sample taken from the mammalian subject before treatment with the melanoma inhibitory agent; (b) determining a second concentration of MIA in a second biological sample from the mammalian subject taken after treatment with the melanoma inhibitory agent; and (c) comparing the first and second concentrations of MIA, wherein a decrease in the second concentration of MIA measured in the second biological sample as compared to the first concentration of MIA measured in the first biological sample indicates a positive response to the treatment with the melanoma inhibitory agent.

摘要翻译： 本发明提供了一种确定具有黑素瘤肿瘤细胞的哺乳动物受试者用黑素瘤抑制剂治疗的反应的方法。 一方面，该方法包括：（a）在用黑素瘤抑制剂处理之前，从取自哺乳动物受试者的第一生物样品中确定黑素瘤抑制活性蛋白（MIA）的第一浓度; （b）在用黑素瘤抑制剂处理后，确定来自哺乳动物受试者的第二生物样品中MIA的第二浓度; 和（c）比较第一和第二浓度的MIA，其中在第二生物样品中测量的MIA的第二浓度的降低与在第一生物样品中测量的MIA的第一浓度相比表明对于用 黑素瘤抑制剂。

公开(公告)号：US20050214300A1

公开(公告)日：2005-09-29

申请号：US10720696

申请日：2003-11-25

申请人： Eleni Venetsanakos

发明人： Eleni Venetsanakos

IPC分类号： A61K20060101 ,  A61K35/14 ,  A61K38/00 ,  A61K39/00 ,  A61K39/395 ,  A61K48/00 ,  C07K1/00 ,  C07K2/00 ,  C07K4/00 ,  C07K5/00 ,  C07K7/00 ,  C07K14/00 ,  C07K14/47 ,  C07K16/00 ,  C07K16/30 ,  C07K17/00 ,  C12P21/08 ,  G01N33/574

CPC分类号： B82Y30/00 ,  A61K2039/505 ,  B82Y15/00 ,  C07K14/4727 ,  C07K16/3092 ,  C07K2317/34 ,  C07K2317/73 ,  G01N33/574 ,  G01N33/57484 ,  G01N2333/4725 ,  G01N2500/00 ,  G01N2500/02

摘要： The present invention relates generally to cancer treatment, prophylaxis, and detection, and more specifically, to Porimin binding partners and methods for using Porimin as a target for the treatment, prophylaxis and/or detection of cancer characterized by Porimin overexpression and/or upregulation.

摘要翻译： 本发明一般涉及癌症治疗，预防和检测，更具体地涉及Porimin结合配偶体和使用Porimin作为治疗，预防和/或检测由Porimin过表达和/或上调表征的癌症的靶标的方法。

公开(公告)号：US08288087B2

公开(公告)日：2012-10-16

申请号：US12375074

申请日：2007-07-26

申请人： Nguyen Tan ,  Eleni Venetsanakos ,  Michel Faure ,  Carla Heise

发明人： Nguyen Tan ,  Eleni Venetsanakos ,  Michel Faure ,  Carla Heise

IPC分类号： G01N33/48 ,  G01N33/50 ,  G01N33/53 ,  G01N33/574

CPC分类号： A61K31/4439 ,  A61K31/44 ,  A61K31/496 ,  G01N33/5743 ,  G01N2333/4704 ,  G01N2500/10

摘要： The present invention provides a method for determining a response of a mammalian subject having melanoma tumor cells to treatment with a melanoma inhibitory agent. In one aspect, the method comprises (a) determining a first concentration of melanoma inhibitory activity protein (MIA) in a first biological sample taken from the mammalian subject before treatment with the melanoma inhibitory agent; (b) determining a second concentration of MIA in a second biological sample from the mammalian subject taken after treatment with the melanoma inhibitory agent; and (c) comparing the first and second concentrations of MIA, wherein a decrease in the second concentration of MIA measured in the second biological sample as compared to the first concentration of MIA measured in the first biological sample indicates a positive response to the treatment with the melanoma inhibitory agent.

摘要翻译： 本发明提供了一种确定具有黑素瘤肿瘤细胞的哺乳动物受试者用黑素瘤抑制剂治疗的反应的方法。 一方面，该方法包括：（a）在用黑素瘤抑制剂处理之前，从取自哺乳动物受试者的第一生物样品中确定黑素瘤抑制活性蛋白（MIA）的第一浓度; （b）在用黑素瘤抑制剂处理后，确定来自哺乳动物受试者的第二生物样品中MIA的第二浓度; 和（c）比较第一和第二浓度的MIA，其中在第二生物样品中测量的MIA的第二浓度的降低与在第一生物样品中测量的MIA的第一浓度相比表明对于用 黑素瘤抑制剂。