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1.发明申请Skin Treatments Containing Carboxylic Acid-Substituted Idebenone Derivatives and Methods of Preparation and Use Thereof 审中-公开包含羧酸取代的艾地苯醌衍生物的皮肤处理及其制备和使用方法公开(公告)号：US20160151260A1
公开(公告)日：2016-06-02
申请号：US15018259
申请日：2016-02-08
发明人： Falko Diedrich , Birgit Neudecker , Eberhard Wieland , Joseph A. Lewis, III , Joespeh C. DiNardo , Andrew S. Thompson , James Alan Kerschen , Peter C. Wade
CPC分类号： A61K8/37 , A61K8/375 , A61K8/67 , A61K8/671 , A61K8/673 , A61K8/676 , A61K8/678 , A61K8/97 , A61Q17/04 , A61Q19/004 , A61Q19/007 , A61Q19/02 , A61Q19/06 , A61Q19/08 , A61Q19/10 , A61Q90/00 , C07C67/08 , C07C67/14 , C07C67/28 , C07C67/31 , C07C69/67 , C07C69/95 , C07C2601/16 , C07C69/28 , C07C69/675
摘要： The present invention relates to novel carboxylic acid-substituted idebenone derivatives, skin treatment compositions containing these carboxylic acid-substituted derivatives, methods of treating skin changes by topical application of these carboxylic acid-substituted idebenone derivatives, and their methods of synthesis. The carboxylic acid-substituted idebenone derivatives of the present invention are unexpectedly effective in treating skin, particularly with respect to skin tolerance. When included in a topical composition, the carboxylic acid-substituted idebenone derivatives of the present invention have an antioxidant effect that is useful in treating a skin change.
摘要翻译： 本发明涉及新颖的羧酸取代的艾地苯醌衍生物，含有这些羧酸取代的衍生物的皮肤处理组合物，通过局部施用这些羧酸取代的艾地苯醌衍生物来治疗皮肤变化的方法及其合成方法。 本发明的羧酸取代的艾地苯醌衍生物在治疗皮肤方面是意想不到的，特别是在皮肤耐受性方面。 当包含在局部组合物中时，本发明的羧酸取代的艾地苯醌衍生物具有可用于治疗皮肤变化的抗氧化作用。
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公开(公告)号：US09290436B2
公开(公告)日：2016-03-22
申请号：US13714136
申请日：2012-12-13
发明人： Falko Diedrich , Birgit Neudecker , Eberhard Wieland , Joseph A. Lewis, II , Joseph C. DiNardo , Andrew S. Thompson , James Alan Kerschen , Peter C. Wade
IPC分类号： A61K31/225 , C07C59/31 , C07C69/95 , A61K8/37 , A61Q19/00 , A61Q19/02 , A61Q19/06 , A61Q19/08 , C07C67/08 , C07C67/14 , C07C67/28 , C07C67/31 , C07C69/67 , A61K8/67 , A61K8/97 , A61Q17/04 , A61Q19/10 , A61Q90/00
CPC分类号： A61K8/37 , A61K8/375 , A61K8/67 , A61K8/671 , A61K8/673 , A61K8/676 , A61K8/678 , A61K8/97 , A61Q17/04 , A61Q19/004 , A61Q19/007 , A61Q19/02 , A61Q19/06 , A61Q19/08 , A61Q19/10 , A61Q90/00 , C07C67/08 , C07C67/14 , C07C67/28 , C07C67/31 , C07C69/67 , C07C69/95 , C07C2601/16 , C07C69/28 , C07C69/675
摘要： The present invention relates to novel carboxylic acid-substituted idebenone derivatives, skin treatment compositions containing these carboxylic acid-substituted derivatives, methods of treating skin changes by topical application of these carboxylic acid-substituted idebenone derivatives, and their methods of synthesis. The carboxylic acid-substituted idebenone derivatives of the present invention are unexpectedly effective in treating skin, particularly with respect to skin tolerance. When included in a topical composition, the carboxylic acid-substituted idebenone derivatives of the present invention have an antioxidant effect that is useful in treating a skin change.
摘要翻译： 本发明涉及新颖的羧酸取代的艾地苯醌衍生物，含有这些羧酸取代的衍生物的皮肤处理组合物，通过局部施用这些羧酸取代的艾地苯醌衍生物来治疗皮肤变化的方法及其合成方法。 本发明的羧酸取代的艾地苯醌衍生物在治疗皮肤方面是意想不到的，特别是在皮肤耐受性方面。 当包含在局部组合物中时，本发明的羧酸取代的艾地苯醌衍生物具有可用于治疗皮肤变化的抗氧化作用。
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3.发明申请Formulations Comprising Idebenone, N-Acetyl-S-Farnesyl-L-Cysteine and Ergothioneine and Uses Thereof 审中-公开包括艾地苯醌，N-乙酰基-S-法呢基-L-半胱氨酸和二硫代硫酸的制剂及其用途公开(公告)号：US20160243011A1
公开(公告)日：2016-08-25
申请号：US14426777
申请日：2013-09-11
发明人： Jose Fernandez , Eduardo Perez , Maxwell Stock , Lavinia Codruta Popescu , Aurelie Nathalie Felix-Gonnot , Arthur Joseph Pellegrino
IPC分类号： A61K8/37 , A61K8/49 , A61Q17/04 , A61Q19/08 , A61K31/198 , A61K31/4172 , A61Q19/00 , A61K8/44 , A61K31/215
CPC分类号： A61K8/37 , A61K8/355 , A61K8/447 , A61K8/4946 , A61K31/122 , A61K31/198 , A61K31/215 , A61K31/4172 , A61K2800/596 , A61K2800/70 , A61Q17/04 , A61Q19/004 , A61Q19/08 , A61K2300/00
摘要： Compositions that mitigate damage caused by environmental stressors are provided. The stressors include, but are not limited to, damage caused by ultra-violet radiation. The compositions comprise an effective amount of idebenone or a derivative thereof, N-acetyl-S-farnesyl-L-cysteine or a pharmaceutically acceptable salt or ester thereof and ergothioneine or a pharmaceutically acceptable salt or ester thereof. In some embodiments these compositions are applied topically to a person's skin.
摘要翻译： 提供减轻环境压力因素造成的损害的组合物。 应激源包括但不限于由紫外辐射引起的损伤。 组合物包含有效量的艾地苯醌或其衍生物，N-乙酰基-S-法呢基-L-半胱氨酸或其药学上可接受的盐或酯和麦角硫素或其药学上可接受的盐或酯。 在一些实施方案中，这些组合物局部施用于人的皮肤。
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4.发明申请SKIN TREATMENTS CONTAINING CARBOXYLIC ACID-SUBSTITUTED IDEBENONE DERlVATIVES AND METHODS OF PREPARATION AND USE THEREOF 有权含有羧基取代的IDEBENONE的皮肤治疗剂及其制备和使用方法公开(公告)号：US20130101534A1
公开(公告)日：2013-04-25
申请号：US13714136
申请日：2012-12-13
发明人： Falko Diedrich , Birgit Neudecker , Eberhard Wieland , Joseph A. Lewis, II , Joseph C. DiNardo , Andrew S. Thompson , James Alan Kerschen , Peter C. Wade
CPC分类号： A61K8/37 , A61K8/375 , A61K8/67 , A61K8/671 , A61K8/673 , A61K8/676 , A61K8/678 , A61K8/97 , A61Q17/04 , A61Q19/004 , A61Q19/007 , A61Q19/02 , A61Q19/06 , A61Q19/08 , A61Q19/10 , A61Q90/00 , C07C67/08 , C07C67/14 , C07C67/28 , C07C67/31 , C07C69/67 , C07C69/95 , C07C2601/16 , C07C69/28 , C07C69/675
摘要： The present invention relates to novel carboxylic acid-substituted idebenone derivatives, skin treatment compositions containing these carboxylic acid-substituted derivatives, methods of treating skin changes by topical application of these carboxylic acid-substituted idebenone derivatives, and their methods of synthesis. The carboxylic acid-substituted idebenone derivatives of the present invention are unexpectedly effective in treating skin, particularly with respect to skin tolerance. When included in a topical composition, the carboxylic acid-substituted idebenone derivatives of the present invention have an antioxidant effect that is useful in treating a skin change.
摘要翻译： 本发明涉及新颖的羧酸取代的艾地苯醌衍生物，含有这些羧酸取代的衍生物的皮肤处理组合物，通过局部施用这些羧酸取代的艾地苯醌衍生物来治疗皮肤变化的方法及其合成方法。 本发明的羧酸取代的艾地苯醌衍生物在治疗皮肤方面是意想不到的，特别是在皮肤耐受性方面。 当包含在局部组合物中时，本发明的羧酸取代的艾地苯醌衍生物具有可用于治疗皮肤变化的抗氧化作用。
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