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公开(公告)号：US20220409351A1
公开(公告)日：2022-12-29
申请号：US17778564
申请日：2020-11-20
发明人： Peter John Zegarelli , Jarret Fass
IPC分类号： A61C19/06 , A61K31/155 , A61K9/06 , A61K47/32
摘要： An oral appliance, a method of making the oral appliance for delivering an antimicrobial composition to an oral cavity and a method of treatment are provided. The oral appliance has an exterior surface and an interior surface, the interior surface of the oral appliance configured to contour at least a portion of teeth and/or soft tissue areas of the oral cavity. The antimicrobial is dispensed by itself or as a composition in a carrier at discrete regions of the interior surface, the exterior surface or both the interior surface and the exterior surface of the oral appliance for delivering the antimicrobial or an antimicrobial composition to the oral cavity, wherein the antimicrobial is present in the carrier in an amount of about 0.01% to about 20% w/w, v/v or w/v based on a total weight or a total volume of the carrier.
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公开(公告)号：US20220395361A1
公开(公告)日：2022-12-15
申请号：US17775085
申请日：2020-11-06
IPC分类号： A61C19/06 , A61K31/155
摘要： An oral appliance for delivering a medicament to an inflamed tissue inside an oral cavity is provided. The oral appliance has an interior surface configured to contour at least a portion of teeth and/or soft tissue areas inside the oral cavity, the interior surface of the oral appliance having a medicament disposed at a discrete region of the interior surface of the oral appliance, the medicament configured to contact a top portion of the inflamed tissue inside the oral cavity when the oral appliance is worn to cause delivery of the medicament to at least the top portion of the inflamed tissue. A method of making the oral appliance and a method of treating an inflamed tissue inside an oral cavity using the oral appliance is also provided.
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公开(公告)号：US20220265410A1
公开(公告)日：2022-08-25
申请号：US17692751
申请日：2022-03-11
发明人： Peter John Zegarelli
摘要： A method of reducing counterfeit medicaments or reducing medicament abuse is provided, the method comprising making an oral appliance for delivering a medicament to teeth and/or soft tissue areas inside an oral cavity, the oral appliance comprising an interior surface having a medicament disposed in or on at least a portion of and/or all of the interior surface of the oral appliance, the interior surface being formed to fit contours of at least the portion of the teeth and/or soft tissue areas inside the oral cavity and being configured for holding the medicament in contact with at least the portion of the teeth and/or soft tissue areas inside the oral cavity to deliver the medicament thereto. In some embodiments, the oral appliance is used in a blockchain system.
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公开(公告)号：US20240307164A1
公开(公告)日：2024-09-19
申请号：US18668824
申请日：2024-05-20
发明人： Peter John Zegarelli
CPC分类号： A61C19/066 , A61C5/90
摘要： A method of reducing counterfeit medicaments or reducing medicament abuse is provided, the method comprising making an oral appliance for delivering a medicament to teeth and/or soft tissue areas inside an oral cavity, the oral appliance comprising an interior surface having a medicament disposed in or on at least a portion of and/or all of the interior surface of the oral appliance, the interior surface being formed to fit contours of at least the portion of the teeth and/or soft tissue areas inside the oral cavity and being configured for holding the medicament in contact with at least the portion of the teeth and/or soft tissue areas inside the oral cavity to deliver the medicament thereto. In some embodiments, the oral appliance is used in a blockchain system.
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公开(公告)号：US11986368B2
公开(公告)日：2024-05-21
申请号：US17692751
申请日：2022-03-11
发明人： Peter John Zegarelli
CPC分类号： A61C19/066 , A61C5/90
摘要： A method of reducing counterfeit medicaments or reducing medicament abuse is provided, the method comprising making an oral appliance for delivering a medicament to teeth and/or soft tissue areas inside an oral cavity, the oral appliance comprising an interior surface having a medicament disposed in or on at least a portion of and/or all of the interior surface of the oral appliance, the interior surface being formed to fit contours of at least the portion of the teeth and/or soft tissue areas inside the oral cavity and being configured for holding the medicament in contact with at least the portion of the teeth and/or soft tissue areas inside the oral cavity to deliver the medicament thereto. In some embodiments, the oral appliance is used in a blockchain system.
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公开(公告)号：US20220257183A1
公开(公告)日：2022-08-18
申请号：US17738614
申请日：2022-05-06
发明人： Peter John Zegarelli
摘要： An apparatus that monitors information associated with an oral cavity is provided, the apparatus comprising: a three-dimensional oral appliance; a data collection device having at least one sensor and/or hydrogel like material configured to sense the information associated with the oral cavity; an interface device cooperatively coupled to the data collection device, the interface device configured to transfer the information from the sensor device to a receiving device external to the oral cavity or the entire device is analyzed.
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公开(公告)号：US20210135547A9
公开(公告)日：2021-05-06
申请号：US16714067
申请日：2019-12-13
发明人： Peter John Zegarelli
摘要： An oral appliance is provided for delivering a medicament to at least a portion of teeth and/or soft tissue areas inside a mouth. The oral appliance contains an interior surface having a medicament disposed in or on at least a portion of and/or the entire interior surface of the oral appliance. The interior surface of the oral cavity is formed to fit contours of at least the portion of the teeth and/or soft tissue areas inside the oral cavity and is configured for holding the medicament in contact with at least the portion of the teeth and/or soft tissue areas inside the oral cavity to deliver the medicament to strategic areas in need of treatment. In some embodiments, computer, network and computer readable storage media are provided.
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公开(公告)号：US20240285554A1
公开(公告)日：2024-08-29
申请号：US18114559
申请日：2023-02-27
CPC分类号： A61K31/155 , A61C19/063 , A61K47/10 , A61K47/34 , C08K5/053 , C08K5/29
摘要： A composition for treating an oral cavity in a patient in need is provided. The composition comprising a medicament, a polyvinyl alcohol (PVA), and optionally a humectant, the medicament in an amount of about 0.001% w/w, v/v or w/v to about 5% w/w, v/v or w/v, the polyvinyl alcohol in an amount of about 5% w/w, v/v or w/v to about 99% w/w, v/v or w/v, the humectant in an amount of about 0.5% w/w, v/v or w/v to about 15% w/w, v/v or w/v based on a total w/w, v/v or w/v of the composition. A method of making a composition for treating an oral cavity in a patient in need is also provided.
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公开(公告)号：US20230270533A1
公开(公告)日：2023-08-31
申请号：US17622632
申请日：2020-11-20
CPC分类号： A61C19/063 , G16H20/13
摘要： An oral appliance and a method of making the oral appliance for delivering a medicament to an oral cavity are provided. The method comprises providing an oral appliance having an exterior and an interior, the interior of the oral appliance configured to contour at least a portion of teeth and/or soft tissue areas of the oral cavity. A robotic dispensing device is provided, the robotic device having an outlet configured to dispense medicament at discrete regions of the interior, the exterior or both the interior and the exterior of the oral appliance; and dispensing the medicament from the outlet of the robotic dispensing device to discrete regions of the interior, the exterior or both the interior and the exterior of the oral appliance for delivering the medicament to the oral cavity.
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公开(公告)号：US20230023921A1
公开(公告)日：2023-01-26
申请号：US17783994
申请日：2020-12-09
IPC分类号： A61C19/06
摘要： An oral appliance for delivering a medicament to an oral cavity is provided, the oral appliance having an interior surface and an exterior surface, the interior surface and/or exterior surface configured to contour a treatment area and deliver medicament thereto, the treatment area comprising soft tissue, hard tissue or a combination of soft tissue and hard tissue, at least a portion of the interior surface and/or exterior surface of the oral appliance being less, equal or greater in hardness, elasticity, flexibility, density, porosity, hydrophobicity, hydrophilicity relative to the treatment area. In some embodiments, the oral appliance is designed based on various material science properties to enhance medicament delivery and patient compliance.
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