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1.发明申请SMMR (small molecule metabolite reporters) for use as in vivo glucose biosensors 有权SMMR（小分子代谢物记者）用作体内葡萄糖生物传感器公开(公告)号：US20070110672A1
公开(公告)日：2007-05-17
申请号：US11475784
申请日：2006-06-26
申请人： Emile Bellott , Dongsheng Bu , James Childs , Christopher Lambert , Hubert Nienaber , Shirley Shi , Zhaolin Wang , Jerome Workman , Alex Zelenchuk
发明人： Emile Bellott , Dongsheng Bu , James Childs , Christopher Lambert , Hubert Nienaber , Shirley Shi , Zhaolin Wang , Jerome Workman , Alex Zelenchuk
CPC分类号： A61K49/0052 , A61K49/0021 , A61K49/0041 , C07F5/025 , C07F7/1804 , Y10T436/144444
摘要： Small Molecule Metabolite Reporters (SMMRs) for use as in vivo glucose biosensors, sensor compositions, and methods of use, are described. The SMMRs include boronic acid-containing xanthene, coumarin, carbostyril and phenalene-based small molecules which are used for monitoring glucose in vivo, advantageously on the skin.
摘要翻译： 描述了用作体内葡萄糖生物传感器，传感器组合物和使用方法的小分子代谢记录（SMMR）。 SMMR包括含有硼酸的呫吨，香豆素，喹诺酮和基于非花叶粉的小分子，其用于体内，有利地在皮肤上监测葡萄糖。
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2.发明授权Derivatives of 4-(thio- or selenoxanthene-9-ylidene)-piperidine or acridine and its use as a selective 5-HT2B receptor antagonist 有权4-（硫代或硒代呫吨-9-亚基） - 哌啶或吖啶的衍生物及其作为选择性5-HT2B受体拮抗剂的用途公开(公告)号：US07511064B2
公开(公告)日：2009-03-31
申请号：US11379353
申请日：2006-04-19
IPC分类号： A61K31/4535 , C07D409/04
CPC分类号： C07D401/04 , C07D409/04 , C07D421/04
摘要： The present invention relates to derivatives of 4-(Thio- or Selenoxanthene-9-ylidene)-piperidine or acridine and pharmaceutically acceptable salts thereof, use of these compounds as a medicament and for the manufacture of a medicament for treatment of a disease state which can be alleviated by treatment with a 5-HT2B antagonist.
摘要翻译： 本发明涉及4-（硫代或硒代呫吨-9-亚基） - 哌啶或吖啶及其药学上可接受的盐的衍生物，这些化合物用作药物和用于制备治疗疾病状态的药物 可以通过用5-HT2B拮抗剂治疗来缓解。
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3.发明申请DERIVATIVES OF 4-(THIO-OR SELENOXANTHENE-9-YLIDENE)-PIPERIDINE OR ACRIDINE AND ITS USE AS A SELECTIVE 5-HT2B RECEPTOR ANTAGONIST 有权4-（三氟甲基-9-基） - 哌啶或嘧啶的衍生物及其作为选择性5-HT 2B受体拮抗剂的用途公开(公告)号：US20060183905A1
公开(公告)日：2006-08-17
申请号：US11379353
申请日：2006-04-19
IPC分类号： C07D219/08 , A61K31/545
CPC分类号： C07D401/04 , C07D409/04 , C07D421/04
摘要： The present invention relates to derivatives of 4-(Thio- or Selenoxanthene-9-ylidene)-piperidine or acridine and pharmaceutically acceptable salts thereof, use of these compounds as a medicament and for the manufacture of a medicament for treatment of a disease state which can be alleviated by treatment with a 5-HT2B antagonist.
摘要翻译： 本发明涉及4-（硫代或硒代呫吨-9-亚基） - 哌啶或吖啶及其药学上可接受的盐的衍生物，这些化合物用作药物和用于制备治疗疾病状态的药物 可以通过用5-HT2B拮抗剂治疗来缓解。
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公开(公告)号：US07060711B2
公开(公告)日：2006-06-13
申请号：US10281415
申请日：2002-10-25
IPC分类号： A61K31/473 , A61K31/4535
CPC分类号： C07D401/04 , C07D409/04 , C07D421/04
摘要： The present invention relates to derivatives of 4-(Thio- or Selenoxanthene-9-ylidene)-piperidine or acridine and pharmaceutically acceptable salts thereof, use of these compounds as a medicament and for the manufacture of a medicament for treatment of a disease state which can be alleviated by treatment with a 5-HT2B antagonist.
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