Salts, Solvates and Pharmaceutical Compositions of Macrocyclic Ghrelin Receptor Agonists and Methods of Using the Same
    1.
    发明申请
    Salts, Solvates and Pharmaceutical Compositions of Macrocyclic Ghrelin Receptor Agonists and Methods of Using the Same 审中-公开
    大环素Ghrelin受体激动剂的盐,溶剂化物和药物组合物及其使用方法

    公开(公告)号:US20110245159A1

    公开(公告)日:2011-10-06

    申请号:US12937040

    申请日:2010-09-29

    CPC classification number: C07D273/00 A61K9/0019

    Abstract: The present invention provides novel salts and solvates of macrocyclic compounds that bind to and/or are functional agonists of the ghrelin (growth hormone secretagogue) receptor. The invention also relates to polymorphs of these salts and solvates, pharmaceutical compositions containing these salts or solvates, and methods of using the pharmaceutical compositions. These pharmaceutical compositions are useful as therapeutics for a range of disease indications, in particular, for treatment and prevention of gastrointestinal disorders including, but not limited to, postoperative ileus, gastroparesis, including diabetic and postsurgical gastroparesis, opioid bowel dysfunction, chronic intestinal pseudo-obstruction, short bowel syndrome, functional gastrointestinal disorders and gastrointestinal dysmotility, such as that occurring in conjunction with other disease states, in critical care situations or as a result of treatment with pharmaceutical agents. Additionally, the pharmaceutical compositions have application to the treatment and prevention of metabolic and/or endocrine disorders, cardiovascular disorders, central nervous system disorders, bone disorders, inflammatory disorders, hyperproliferative disorders, disorders characterized by apoptosis and genetic disorders.

    Abstract translation: 本发明提供与生长素释放肽(生长激素促分泌素)受体结合和/或是功能性激动剂的大环化合物的新型盐和溶剂化物。 本发明还涉及这些盐和溶剂合物的多晶型物,含有这些盐或溶剂化物的药物组合物,以及使用该药物组合物的方法。 这些药物组合物可用作一系列疾病适应症,特别是用于治疗和预防胃肠道疾病的治疗剂,包括但不限于术后肠梗阻,胃轻瘫,包括糖尿病和手术后胃轻瘫,阿片样物质肠功能障碍, 梗阻,短肠综合征,功能性胃肠道疾病和胃肠动力障碍,例如与其他疾病状态一起发生,在重症监护情况下或作为药物治疗的结果。 此外,药物组合物可用于治疗和预防代谢和/或内分泌疾病,心血管疾病,中枢神经系统疾病,骨骼疾病,炎症性疾病,过度增殖性疾病,以凋亡和遗传疾病为特征的疾病。

    Autonomous gravity-feed beverage dispenser with cooling device
    2.
    发明授权
    Autonomous gravity-feed beverage dispenser with cooling device 失效
    具有冷却装置的自动重力给料饮料机

    公开(公告)号:US06442960B1

    公开(公告)日:2002-09-03

    申请号:US09830583

    申请日:2001-09-10

    Abstract: A gravity-feed unit that dispenses cool drinks form a carboy includes a breakable inner seal. The carboy is supported by its neck, which is centered on a striker. The striker includes a discharge passage for the carboy that communicates with a coiled pipe to cause the beverage to flow through a secondary exchanger. A heat transferring agent is previously cooled in a primary exchanger and brought to the secondary exchanger by a pump. Actuation is controlled by a temperature sensor that measures the temperature of the heat transfer agent in the secondary exchanger. The primary exchanger includes a heat source that causes the heat transfer agent to pass continuously inside a closed circuit mutually connecting the primary and secondary exchangers regardless of whether the pump is operating.

    Abstract translation: 分配冷饮料的重力进料单元包含一个易碎的内部密封件。 它的颈部支撑着它的脖子,它以前锋为中心。 撞击器包括用于与线圈管连通以使饮料流过二次交换器的碳罐的排放通道。 传热剂预先在主交换器中冷却并通过泵送到二次交换器。 致动由温度传感器控制,温度传感器测量二次换热器中传热剂的温度。 主要交换器包括热源,其导致传热剂连续地通过相互连接初级和次级换热器的闭合回路,而不管泵是否运行。

    Helmet adjustment mechanism with quick release
    3.
    发明授权
    Helmet adjustment mechanism with quick release 有权
    头盔调节机构快速释放

    公开(公告)号:US6108824A

    公开(公告)日:2000-08-29

    申请号:US132834

    申请日:1998-08-12

    CPC classification number: A42B3/324

    Abstract: A helmet comprising a helmet front half section, helmet rear half section and a locking assembly. The helmet front half section includes at least one engagement region. The helmet rear half section includes at least one corresponding engagement region. The locking assembly a structure for orientating the locking assembly between a locked position and an unlocked position. In the locked position, the locking assembly results in secured engagement of the at least one engagement region of the front and rear helmet half sections with each other. The unlocked position facilitates slidable movement of the at least one engagement region of the front and rear helmet half sections and, in turn, the helmet half sections, relative to each other

    Abstract translation: 头盔包括头盔前半部分,头盔后半部分和锁定组件。 头盔前半部分包括至少一个接合区域。 头盔后半部分包括至少一个对应的接合区域。 锁定组件用于将锁定组件定位在锁定位置和解锁位置之间的结构。 在锁定位置,锁定组件导致前后头盔半部分的至少一个接合区域与彼此的固定接合。 解锁位置有助于前后头盔半部分的至少一个接合区域的滑动运动,并且相应地相对于头盔半部分

    WATERCRAFT TRAILER
    4.
    发明申请
    WATERCRAFT TRAILER 有权
    水上拖车

    公开(公告)号:US20110181019A1

    公开(公告)日:2011-07-28

    申请号:US13083117

    申请日:2011-04-08

    CPC classification number: B60P3/1033 B60P3/1066

    Abstract: A method of securing a watercraft to a watercraft trailer is disclosed. The method includes driving the watercraft in a watercraft receiving portion of the trailer, moving a lever towards a front of the trailer in response to a hull of the watercraft coming into contact with the lever, and retaining a pin connected to the hull of the watercraft in response to the lever moving towards the front of the trailer. A method of releasing a watercraft from a watercraft trailer is also disclosed.

    Abstract translation: 公开了一种将船只固定在船舶拖车上的方法。 该方法包括:将拖船内的船舶接收部分的船只驱动,响应于与船杆接触的船舶的船体,将杠杆朝着拖车的前方移动,并且保持与船只的船体连接的销 响应于杠杆朝向拖车的前部移动。 还公开了一种从船只拖车释放船只的方法。

    WATERCRAFT TRAILER
    5.
    发明申请
    WATERCRAFT TRAILER 有权
    水上拖车

    公开(公告)号:US20110181017A1

    公开(公告)日:2011-07-28

    申请号:US12672130

    申请日:2008-04-30

    CPC classification number: B60P3/1033 B60P3/1066

    Abstract: A watercraft trailer has a watercraft receiving portion and a lower frame adapted to support a watercraft in the watercraft receiving portion. The lower frame has at least one longitudinally extending lower frame member. The trailer also has a hitch coupler connected to a front of the lower frame, a first wheel and a second wheel operatively connected to the lower frame, and a walk board connected to the lower frame.

    Abstract translation: 船舶拖车具有船舶接收部分和适于在船只接收部分中支撑船只的下部框架。 下框架具有至少一个纵向延伸的下框架构件。 拖车还具有连接到下框架的前部的挂钩联接器,可操作地连接到下框架的第一轮和第二轮以及连接到下框架的步行板。

    Watercraft trailer having an intake protector
    6.
    发明授权
    Watercraft trailer having an intake protector 有权
    船舶拖车具有进气保护器

    公开(公告)号:US07891689B2

    公开(公告)日:2011-02-22

    申请号:US12263037

    申请日:2008-10-31

    CPC classification number: B60P3/1033 B60P3/1066

    Abstract: A watercraft trailer has a watercraft receiving portion and a lower frame adapted to support a watercraft in the watercraft receiving portion. The lower frame has at least one a longitudinally extending member, a front portion, and a rear portion, a rearmost part of the rear portion being a rear end. The trailer also has a hitch coupler connected to the front portion of the lower frame, a first wheel, having a rotation axis, and a second wheel operatively connected to the lower frame. The trailer has a longitudinally extending intake protector connected to the rear portion of the lower frame. At least a portion of the intake protector is disposed between the rotation axis and the rear end of the lower frame, such that when the watercraft is received in the watercraft receiving portion, the intake protector is disposed below at least a portion of the watercraft.

    Abstract translation: 船舶拖车具有船舶接收部分和适于在船只接收部分中支撑船只的下部框架。 下框架具有至少一个纵向延伸的构件,前部和后部,后部的最后部分是后端。 拖车还具有连接到下框架的前部的挂钩联接器,具有旋转轴线的第一轮和可操作地连接到下框架的第二轮。 拖车具有连接到下框架的后部的纵向延伸的进气保护器。 进气保护器的至少一部分设置在下框架的旋转轴线和后端之间,使得当船只被接收在船只接收部分中时,进气保护器设置在船舶的至少一部分下方。

    Fluid cooling system, cooled fluid dispenser comprising the later, and methods for sterilization thereof
    7.
    发明授权
    Fluid cooling system, cooled fluid dispenser comprising the later, and methods for sterilization thereof 失效
    流体冷却系统,后者的冷却流体分配器及其灭菌方法

    公开(公告)号:US07571621B2

    公开(公告)日:2009-08-11

    申请号:US10539911

    申请日:2003-12-17

    Abstract: The present invention relates to a fluid cooling system (1), for use in dispensing or distributing a chilled or cooled fluid, comprising a primary heat exchanger system (2), a secondary heat exchanger system (3), a first conduit (9) through which fluid to be cooled or chilled is circulated, and a heat transfer agent (8) for transferring cooling energy to the fluid to be chilled circulating in the first conduit (9), wherein the primary and secondary heat exchanger systems (2, 3) are arranged at least partially one inside of another The invention also relates to cooled fluid dispensers incorporating the fluid cooling system and a methods for sterilization thereof.

    Abstract translation: 本发明涉及用于分配或分配冷却或冷却流体的流体冷却系统(1),其包括主热交换器系统(2),二次热交换器系统(3),第一导管(9) 通过其冷却或冷却的流体循环;以及传热剂(8),用于将冷却能量传递到在第一管道(9)中循环的要冷却的流体,其中,一次和二次热交换器系统(2,3) )至少部分地布置在另一个内部本发明还涉及结合流体冷却系统的冷却流体分配器及其灭菌方法。

    ELECTRIC MOTOR BRUSH
    8.
    发明申请
    ELECTRIC MOTOR BRUSH 有权
    电动马达

    公开(公告)号:US20090152978A1

    公开(公告)日:2009-06-18

    申请号:US12087693

    申请日:2006-12-13

    CPC classification number: H01R39/18 H01R39/26 H01R39/58 H01R43/12

    Abstract: The present invention relates to a brush 10 suitable for coming into contact with conducting plates 12 provided on an electric motor commutator 11. According to the invention, the brush has a means 15 for adjusting its pole coverage between the start of life of the motor and its stabilized operation. This is therefore a brush with pole coverage that can be varied over its operating life. Such a brush is more particularly fitted into a motor for a ventilation (air conditioning) system for motor vehicle.

    Abstract translation: 本发明涉及一种适于与设置在电动机换向器11上的导电板12接触的电刷10.根据本发明,电刷具有一个装置15,用于调节电动机寿命的起始点和 其稳定运行。 因此,这是一个具有极点覆盖的刷子,可以在其使用寿命内变化。 这种刷子更特别地装配在用于机动车辆的通风(空调)系统的电动机中。

    Cooling unit for a drinking water fountain, and water fountain containing such a unit
    9.
    发明申请
    Cooling unit for a drinking water fountain, and water fountain containing such a unit 审中-公开
    饮水机的冷却单元,以及含有这样一个单元的喷泉

    公开(公告)号:US20090090119A1

    公开(公告)日:2009-04-09

    申请号:US10590767

    申请日:2005-02-24

    CPC classification number: F25D31/002

    Abstract: A self-contained cooling unit for drinking water fountains, wherein the cooling unit includes an outer casing (2) forming a fluidtight chamber. A thermal exchange fluid is held within the chamber. Also a source of cold energy is transferable to the thermal exchange fluid. Additionally at least one drinking water conduit is arranged within the chamber, having a drinking water inlet and a drinking water outlet outside of said chamber.

    Abstract translation: 一种用于饮用水喷泉的独立冷却单元,其中冷却单元包括形成流体密封室的外壳(2)。 热交换流体保持在室内。 冷能源也可转移到热交换流体。 另外,在该腔室内设置至少一个饮用水导管,在该腔室外部具有饮用水入口和饮用水出口。

    Cold-weather helmet with removable jaw shield
    10.
    发明授权
    Cold-weather helmet with removable jaw shield 有权
    寒冷的头盔与可拆卸的颚盾

    公开(公告)号:US06928662B2

    公开(公告)日:2005-08-16

    申请号:US10386026

    申请日:2003-03-12

    Applicant: Eric Fournier

    Inventor: Eric Fournier

    Abstract: A helmet is particularly well suited for cold-weather use. The helmet includes a jaw shield that is detachable from a head portion. A breathing mask connects to the jaw shield via a mask adjustment mechanism that selectively axially moves the breathing mask toward and away from an inner surface of the jaw shield to precisely and accurately position the breathing mask against the nose and mouth of the helmet's wearer. A spring-loaded quick-release tinted shield is controlled by a lever that selectively raises and lowers the tinted shield. An eye shield pivotally connects to the helmet and is disposed in front of the tinted shield. An eye shield heating system on the eye shield electrically connects to the head portion of the helmet to provide electric power to the heating system.

    Abstract translation: 头盔特别适合寒冷天气使用。 头盔包括可脱离头部的钳口护罩。 呼吸面罩通过面罩调节机构连接到钳口护罩,该机构选择性地使呼吸面罩朝向和离开颚护罩的内表面移动,以将呼吸面罩精确地和准确地定位在头戴戴戴者的鼻子和嘴部上。 弹簧加载的快速释放着色屏蔽由选择性地升高和降低着色屏蔽的杠杆控制。 眼罩可枢转地连接到头盔,并且设置在有色屏蔽的前面。 护眼罩上的眼罩加热系统电连接到头盔的头部以向加热系统提供电力。

Patent Agency Ranking