Stereoselective epoxidation of alkenes by chloroperoxidase
    3.
    发明授权
    Stereoselective epoxidation of alkenes by chloroperoxidase 失效
    氯过氧化物酶对烯烃的立体选择性环氧化反应

    公开(公告)号:US5358860A

    公开(公告)日:1994-10-25

    申请号:US43049

    申请日:1993-04-05

    摘要: A method of converting olefins to chiral epoxides comprises combining an asymmetric aliphatic or aryl alkene substrate with a buffered chloroperoxidase solution to form a stabilized reaction mixture, and gradually adding hydrogen peroxide as a substrate oxidant, such that the chloroperoxidase catalyzes the conversion of the substrate to the corresponding epoxide in enantiomeric excess. The products of the invention are alkyl and aryl non-primary epoxides. The resulting preparations are enantiomerically pure, and may greatly enhance large-scale synthesis of stereoisomer products such as pharmaceuticals and pesticides.

    摘要翻译: 将烯烃转化为手性环氧化物的方法包括将不对称脂族或芳基烯底物与缓冲的氯过氧化物酶溶液组合以形成稳定的反应混合物,并逐渐加入过氧化氢作为底物氧化剂,使得氯过氧化物酶催化底物转化为 相应的环氧化物在对映体过量。 本发明的产物是烷基和芳基非伯环氧化物。 所得制剂是对映异构体纯的,并且可以大大增强立体异构体产物如药物和农药的大规模合成。