公开(公告)号：US20070134774A1

公开(公告)日：2007-06-14

申请号：US11624096

申请日：2007-01-17

申请人： Peter Michels ,  Eric Zirbes

发明人： Peter Michels ,  Eric Zirbes

IPC分类号： C12P17/12

CPC分类号： C12P17/12 ,  C07D211/46 ,  C07D211/70

摘要： The present invention relates to the production of a product compound having a structure according to Formulae IA and/or IB: wherein n is 0 or 1; R1 is hydrogen or hydroxy; R2 is hydrogen; or, when n is 0, R1 and R2 taken together form a second bond between the carbon atoms bearing R1 and R2, provided that when n is 1, R1 and R2 are each hydrogen; R3 is —COOH or —COOR4; R4 is an alkyl or aryl moiety; A, B, and D are the substituents of their rings, each of which may be different or the same, and are selected from the group consisting of hydrogen, halogens, alkyl, hydroxy, and alkoxy. This process involves incubating a starting compound having a structure according to Formulae IIA and/or IIB: wherein R3 is —CH3 and R1, R2, A, B, and D are defined above. in the presence of a microorganism under conditions effective to produce the product compound. The microorganism can be from the genus Streptomyces, Stemphylium, Gliocladium, Bacillus, Botrytis, Cyathus, Rhizopus, Pycniodosphora, Pseudomonas, Helicostylum, Aspergillus, Mucor, Gelasinospora, Rhodotorula, Candida, Mycobacterium, or Penicillium. Alternatively, the microorganism can be Cunninghamella bainieri.

摘要翻译： 本发明涉及具有根据式IA和/或IB的结构的产物化合物的制备：其中n为0或1; R 1是氢或羟基; R 2是氢; 或者当n为0时，R 1和R 2一起形成带有R 1和R 2的碳原子之间的第二个键 > 2 ，条件是当n为1时，R 1和R 2各自为氢; R 3是-COOH或-COOR 4; R 4是烷基或芳基部分; A，B和D是它们的环的取代基，其各自可以不同或相同，并且选自氢，卤素，烷基，羟基和烷氧基。 该方法包括孵育具有根据式IIA和/或IIB的结构的起始化合物：其中R 3是-CH 3 3和R 1， R 2，A，B和D如上所定义。 在有效产生产物化合物的条件下在微生物存在下进行。 微生物可以来自链霉菌属，茎状杆菌属，胶霉属，芽孢杆菌属，Botrytis，Cyathus，Rhizopus，Pycniodosphora，假单胞菌属，Helicostylum，曲霉属，Mucor，Gelasinospora，Rhodotorula，Candida，Mycobacterium或Penicillium。 或者，微生物可以是贻贝（Cunninghamella bainieri）。

公开(公告)号：US20050038254A1

公开(公告)日：2005-02-17

申请号：US10638841

申请日：2003-08-11

申请人： Peter Michels ,  Eric Zirbes

发明人： Peter Michels ,  Eric Zirbes

IPC分类号： C12P17/12 ,  C07D211/46 ,  C07D211/70 ,  C12N1/14 ,  C12N1/20 ,  C12R1/465 ,  C07D211/52 ,  C07D211/20 ,  C07D211/34

CPC分类号： C12P17/12 ,  C07D211/46 ,  C07D211/70

摘要： The present invention relates to the production of a product compound having a structure according to Formulae IA and/or IB: wherein n is 0 or 1; R1 is hydrogen or hydroxy; R2 is hydrogen; or, when n is 0, R1 and R2 taken together form a second bond between the carbon atoms bearing R1 and R2, provided that when n is 1, R1 and R2 are each hydrogen; R3 is —COOH or —COOR4; R4 is an alkyl or aryl moiety; A, B, and D are the substituents of their rings, each of which may be different or the same, and are selected from the group consisting of hydrogen, halogens, alkyl, hydroxy, and alkoxy. This process involves incubating a starting compound having a structure according to Formulae IIA and/or IIB: wherein R3 is —CH3 and R1, R2, A, B, and D are defined above. in the presence of a microorganism under conditions effective to produce the product compound. The microorganism can be from the genus Streptomyces, Stemphylium, Gliocladium, Bacillus, Botrytis, Cyathus, Rhizopus, Pycniodosphora, Pseudomonas, Helicostylum, Aspergillus, Mucor, Gelasinospora, Rhodotorula, Candida, Mycobacterium, or Penicillium. Alternatively, the microorganism can be Cunninghamella bainieri.

摘要翻译： 本发明涉及具有根据式IA和/或IB的结构的产物化合物的制备：其中n为0或1; R 1是氢或羟基; R 2是氢; 或者当n为0时，R 1和R 2一起形成在具有R 1和R 2的碳原子之间的第二个键，条件是当n为1时，R 1和R 2 2是氢; R 3是-COOH或-COOR 4; R 4是烷基或芳基部分; A，B和D是它们的环的取代基，其各自可以不同或相同，并且选自氢，卤素，烷基，羟基和烷氧基。 该方法包括孵育具有式IIA和/或IIB结构的起始化合物：其中R 3为-CH 3且R 1，R 2，A，B和D如上所定义。 在有效产生产物化合物的条件下在微生物存在下进行。 微生物可以来自链霉菌属，茎状杆菌属，胶霉属，芽孢杆菌属，Botrytis，Cyathus，Rhizopus，Pycniodosphora，假单胞菌属，Helicostylum，曲霉属，Mucor，Gelasinospora，Rhodotorula，Candida，Mycobacterium或Penicillium。 或者，微生物可以是贻贝（Cunninghamella bainieri）。