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公开(公告)号：US20140074408A1
公开(公告)日：2014-03-13
申请号：US14077733
申请日：2013-11-12
IPC分类号： G06F19/10
摘要： A method for operating a machine for identifying a mechanism associated with a cellular response includes identifying molecules participating in the cellular response, accessing a database containing information characterizing molecular interactions, determining pathways connecting the identified molecules participating in the response, and solving an optimization problem. The pathways comprise nodes, each representing a molecule, and edges, each connecting a pair of nodes and representing an interaction between a respective pair of molecules represented by the pair of nodes. The nodes includes a subset that represent molecules identified as participating in the cellular response. Solving an optimization problem comprises determining a subset of the molecules and interactions having a minimum aggregate cost, associating each participating node with a penalty value, associating each edge with a cost value, forming an objective function based on the penalty and cost values, and identifying the sub-network of nodes and edges that minimizes the objective function.
摘要翻译： 用于操作用于识别与细胞反应相关的机制的机器的方法包括识别参与细胞反应的分子，访问包含表征分子相互作用的信息的数据库，确定参与响应的所识别分子的连接途径以及解决优化问题。 这些路径包括每个表示分子的节点和边缘，每个节点连接一对节点并且表示由该对节点表示的相应的一对分子之间的相互作用。 节点包括表示被鉴定为参与细胞反应的分子的子集。 解决优化问题包括确定分子的子集和具有最小总成本的交互，将每个参与节点与惩罚值相关联，将每个边缘与成本值相关联，基于惩罚和成本值形成目标函数，以及识别 节点和边缘的子网络使目标函数最小化。
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公开(公告)号：US20100250143A1
公开(公告)日：2010-09-30
申请号：US12618915
申请日：2009-11-16
IPC分类号： G06F19/00
摘要： A method for identifying a mechanism associated with a cellular response includes identifying molecules participating in the cellular response; accessing a database containing information characterizing molecular interactions; determining pathways connecting the identified molecules participating in the cellular response; and solving an optimization problem that includes determining a subset of the molecules and interactions having a minimum aggregate cost. The pathways include, nodes, each representing a molecule, and edges, each connecting a respective pair of nodes and representing an interaction between a respective pair of molecules represented by the respective pair of nodes. Nodes from a subset of nodes represent molecules identified as participating in the cellular response.
摘要翻译： 用于鉴定与细胞反应相关的机制的方法包括鉴定参与细胞反应的分子; 访问包含表征分子相互作用的信息的数据库; 确定连接参与细胞反应的鉴定分子的途径; 并解决优化问题，其包括确定具有最小总成本的分子和相互作用的子集。 路径包括每个表示分子的节点和边缘，每个边缘连接相应的一对节点，并且表示由相应对节点对表示的相应分子对之间的相互作用。 来自节点子集的节点表示鉴定为参与细胞反应的分子。
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公开(公告)号：US08612160B2
公开(公告)日：2013-12-17
申请号：US12618915
申请日：2009-11-16
摘要： A method for identifying a mechanism associated with a cellular response includes identifying molecules participating in the cellular response; accessing a database containing information characterizing molecular interactions; determining pathways connecting the identified molecules participating in the cellular response; and solving an optimization problem that includes determining a subset of the molecules and interactions having a minimum aggregate cost. The pathways include, nodes, each representing a molecule, and edges, each connecting a respective pair of nodes and representing an interaction between a respective pair of molecules represented by the respective pair of nodes. Nodes from a subset of nodes represent molecules identified as participating in the cellular response.
摘要翻译： 用于鉴定与细胞反应相关的机制的方法包括鉴定参与细胞反应的分子; 访问包含表征分子相互作用的信息的数据库; 确定连接参与细胞反应的鉴定分子的途径; 并解决优化问题，其包括确定具有最小总成本的分子和相互作用的子集。 路径包括每个表示分子的节点和边缘，每个边缘连接相应的一对节点，并且表示由相应对节点对表示的相应分子对之间的相互作用。 来自节点子集的节点表示鉴定为参与细胞反应的分子。
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