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公开(公告)号：US08612160B2
公开(公告)日：2013-12-17
申请号：US12618915
申请日：2009-11-16
摘要： A method for identifying a mechanism associated with a cellular response includes identifying molecules participating in the cellular response; accessing a database containing information characterizing molecular interactions; determining pathways connecting the identified molecules participating in the cellular response; and solving an optimization problem that includes determining a subset of the molecules and interactions having a minimum aggregate cost. The pathways include, nodes, each representing a molecule, and edges, each connecting a respective pair of nodes and representing an interaction between a respective pair of molecules represented by the respective pair of nodes. Nodes from a subset of nodes represent molecules identified as participating in the cellular response.
摘要翻译： 用于鉴定与细胞反应相关的机制的方法包括鉴定参与细胞反应的分子; 访问包含表征分子相互作用的信息的数据库; 确定连接参与细胞反应的鉴定分子的途径; 并解决优化问题，其包括确定具有最小总成本的分子和相互作用的子集。 路径包括每个表示分子的节点和边缘，每个边缘连接相应的一对节点，并且表示由相应对节点对表示的相应分子对之间的相互作用。 来自节点子集的节点表示鉴定为参与细胞反应的分子。
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公开(公告)号：US08484319B2
公开(公告)日：2013-07-09
申请号：US13400146
申请日：2012-02-20
申请人： Joel M. Wein , David R. Karger , John Joseph Kloninger , Philip A. Lisiecki , Mark C. Nottingham
发明人： Joel M. Wein , David R. Karger , John Joseph Kloninger , Philip A. Lisiecki , Mark C. Nottingham
IPC分类号： G06F15/16
CPC分类号： H04L61/1576 , H04L61/1511 , H04L63/08 , H04L65/1063 , H04L65/4069 , H04L67/02 , H04L67/1002 , H04L67/1006 , H04L67/1008
摘要： To serve content through a content delivery network (CDN), the CDN must have some information about the identity, characteristics and state of its target objects. Such additional information is provided in the form of object metadata, which according to the invention can be located in the request string itself, in the response headers from the origin server, in a metadata configuration file distributed to CDN servers, or in a per-customer metadata configuration file. CDN content servers execute a request identification and parsing process to locate object metadata and to handle the request in accordance therewith. Where different types of metadata exist for a particular object, metadata in a configuration file is overridden by metadata in a response header or request string, with metadata in the request string taking precedence.
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3.发明申请Content delivery network (CDN) content server request handling mechanism with metadata framework support 有权内容传递网络（CDN）内容服务器请求处理机制，具有元数据框架支持公开(公告)号：US20120151016A1
公开(公告)日：2012-06-14
申请号：US13400146
申请日：2012-02-20
申请人： Joel M. Wein , John Joseph Kloninger , Mark C. Nottingham , David R. Karger , Philip A. Lisiecki
发明人： Joel M. Wein , John Joseph Kloninger , Mark C. Nottingham , David R. Karger , Philip A. Lisiecki
IPC分类号： G06F15/16
CPC分类号： H04L61/1576 , H04L61/1511 , H04L63/08 , H04L65/1063 , H04L65/4069 , H04L67/02 , H04L67/1002 , H04L67/1006 , H04L67/1008
摘要： To serve content through a content delivery network (CDN), the CDN must have some information about the identity, characteristics and state of its target objects. Such additional information is provided in the form of object metadata, which according to the invention can be located in the request string itself, in the response headers from the origin server, in a metadata configuration file distributed to CDN servers, or in a per-customer metadata configuration file. CDN content servers execute a request identification and parsing process to locate object metadata and to handle the request in accordance therewith. Where different types of metadata exist for a particular object, metadata in a configuration file is overridden by metadata in a response header or request string, with metadata in the request string taking precedence.
摘要翻译： 为了通过内容传递网络（CDN）提供内容，CDN必须具有关于其目标对象的身份，特征和状态的一些信息。 这样的附加信息以对象元数据的形式提供，其根据本发明可以位于请求字符串本身，来自原始服务器的响应头部，分发到CDN服务器的元数据配置文件中， 客户元数据配置文件。 CDN内容服务器执行请求标识和解析过程以定位对象元数据并根据其处理请求。 在特定对象存在不同类型的元数据的情况下，配置文件中的元数据将在响应头或请求字符串中的元数据覆盖，请求字符串中的元数据优先。
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公开(公告)号：US20100250143A1
公开(公告)日：2010-09-30
申请号：US12618915
申请日：2009-11-16
IPC分类号： G06F19/00
摘要： A method for identifying a mechanism associated with a cellular response includes identifying molecules participating in the cellular response; accessing a database containing information characterizing molecular interactions; determining pathways connecting the identified molecules participating in the cellular response; and solving an optimization problem that includes determining a subset of the molecules and interactions having a minimum aggregate cost. The pathways include, nodes, each representing a molecule, and edges, each connecting a respective pair of nodes and representing an interaction between a respective pair of molecules represented by the respective pair of nodes. Nodes from a subset of nodes represent molecules identified as participating in the cellular response.
摘要翻译： 用于鉴定与细胞反应相关的机制的方法包括鉴定参与细胞反应的分子; 访问包含表征分子相互作用的信息的数据库; 确定连接参与细胞反应的鉴定分子的途径; 并解决优化问题，其包括确定具有最小总成本的分子和相互作用的子集。 路径包括每个表示分子的节点和边缘，每个边缘连接相应的一对节点，并且表示由相应对节点对表示的相应分子对之间的相互作用。 来自节点子集的节点表示鉴定为参与细胞反应的分子。
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公开(公告)号：US20140074408A1
公开(公告)日：2014-03-13
申请号：US14077733
申请日：2013-11-12
IPC分类号： G06F19/10
摘要： A method for operating a machine for identifying a mechanism associated with a cellular response includes identifying molecules participating in the cellular response, accessing a database containing information characterizing molecular interactions, determining pathways connecting the identified molecules participating in the response, and solving an optimization problem. The pathways comprise nodes, each representing a molecule, and edges, each connecting a pair of nodes and representing an interaction between a respective pair of molecules represented by the pair of nodes. The nodes includes a subset that represent molecules identified as participating in the cellular response. Solving an optimization problem comprises determining a subset of the molecules and interactions having a minimum aggregate cost, associating each participating node with a penalty value, associating each edge with a cost value, forming an objective function based on the penalty and cost values, and identifying the sub-network of nodes and edges that minimizes the objective function.
摘要翻译： 用于操作用于识别与细胞反应相关的机制的机器的方法包括识别参与细胞反应的分子，访问包含表征分子相互作用的信息的数据库，确定参与响应的所识别分子的连接途径以及解决优化问题。 这些路径包括每个表示分子的节点和边缘，每个节点连接一对节点并且表示由该对节点表示的相应的一对分子之间的相互作用。 节点包括表示被鉴定为参与细胞反应的分子的子集。 解决优化问题包括确定分子的子集和具有最小总成本的交互，将每个参与节点与惩罚值相关联，将每个边缘与成本值相关联，基于惩罚和成本值形成目标函数，以及识别 节点和边缘的子网络使目标函数最小化。
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6.发明授权公开(公告)号：US08122102B2
公开(公告)日：2012-02-21
申请号：US11772547
申请日：2007-07-02
申请人： Joel M. Wein , John Josef Kloninger , Mark C. Nottingham , David R. Karger , Philip A. Lisiecki
发明人： Joel M. Wein , John Josef Kloninger , Mark C. Nottingham , David R. Karger , Philip A. Lisiecki
IPC分类号： G06G15/16
CPC分类号： H04L61/1576 , H04L61/1511 , H04L63/08 , H04L65/1063 , H04L65/4069 , H04L67/02 , H04L67/1002 , H04L67/1006 , H04L67/1008
摘要： To serve content through a content delivery network (CDN), the CDN must have some information about the identity, characteristics and state of its target objects. Such additional information is provided in the form of object metadata, which according to the invention can be located in the request string itself, in the response headers from the origin server, in a metadata configuration file distributed to CDN servers, or in a per-customer metadata configuration file. CDN content servers execute a request identification and parsing process to locate object metadata and to handle the request in accordance therewith. Where different types of metadata exist for a particular object, metadata in a configuration file is overridden by metadata in a response header or request string, with metadata in the request string taking precedence.
摘要翻译： 为了通过内容传递网络（CDN）提供内容，CDN必须具有关于其目标对象的身份，特征和状态的一些信息。 这样的附加信息以对象元数据的形式提供，其根据本发明可以位于请求字符串本身，来自原始服务器的响应头部，分发到CDN服务器的元数据配置文件中， 客户元数据配置文件。 CDN内容服务器执行请求标识和解析过程以定位对象元数据并根据其处理请求。 在特定对象存在不同类型的元数据的情况下，配置文件中的元数据将在响应头或请求字符串中的元数据覆盖，请求字符串中的元数据优先。
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7.发明授权Content delivery network (CDN) content server request handling mechanism with metadata framework support 有权内容传递网络（CDN）内容服务器请求处理机制，具有元数据框架支持公开(公告)号：US07240100B1
公开(公告)日：2007-07-03
申请号：US09835663
申请日：2001-04-16
申请人： Joel M. Wein , John Josef Kloninger , Mark C. Nottingham , David R. Karger , Philip A. Lisiecki
发明人： Joel M. Wein , John Josef Kloninger , Mark C. Nottingham , David R. Karger , Philip A. Lisiecki
IPC分类号： G06F15/167
CPC分类号： H04L61/1576 , H04L61/1511 , H04L63/08 , H04L65/1063 , H04L65/4069 , H04L67/02 , H04L67/1002 , H04L67/1006 , H04L67/1008
摘要： To serve content through a content delivery network (CDN), the CDN must have some information about the identity, characteristics and state of its target objects. Such additional information is provided in the form of object metadata, which according to the invention can be located in the request string itself, in the response headers from the origin server, in a metadata configuration file distributed to CDN servers, or in a per-customer metadata configuration file. CDN content servers execute a request identification and parsing process to locate object metadata and to handle the request in accordance therewith. Where different types of metadata exist for a particular object, metadata in a configuration file is overridden by metadata in a response header or request string, with metadata in the request string taking precedence.
摘要翻译： 为了通过内容传递网络（CDN）提供内容，CDN必须具有关于其目标对象的身份，特征和状态的一些信息。 这样的附加信息以对象元数据的形式提供，其根据本发明可以位于请求字符串本身，来自原始服务器的响应头部，分发到CDN服务器的元数据配置文件中， 客户元数据配置文件。 CDN内容服务器执行请求标识和解析过程以定位对象元数据并根据其处理请求。 在特定对象存在不同类型的元数据的情况下，配置文件中的元数据将在响应头或请求字符串中的元数据覆盖，请求字符串中的元数据优先。
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8.发明授权
公开(公告)号：US5483650A
公开(公告)日：1996-01-09
申请号：US79292
申请日：1993-06-21
IPC分类号： G06F17/30
CPC分类号： G06F17/3071 , G06F17/30011 , Y10S707/99932
摘要： Arbitrarily large document collections are processed by expanding a focus set having at least one initial metadocument into a plurality of subsequent metadocuments. The number of subsequent metadocuments is approximately equal to a predetermined maximum number. The subsequent metadocuments are then clustered into a predetermined number of new metadocuments, which are summarized and presented to a user. The focus set is redefined to include only user-selected new metadocuments.
摘要翻译： 通过将具有至少一个初始元文件的焦点集扩展到多个后续元文件来处理任意大的文档集合。 随后的元文件数量大约等于预定的最大数量。 随后的元文件然后被聚集成预定数量的新的元文件，其被汇总并呈现给用户。 焦点集被重新定义为仅包括用户选择的新的元文件。
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