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公开(公告)号：US20100291071A1
公开(公告)日：2010-11-18
申请号：US12533294
申请日：2009-07-31
IPC分类号： A61K39/395 , C07K16/18 , G01N33/566 , A61P25/28 , A61P25/00
CPC分类号： G01N33/6896 , A61K2039/505 , C07K16/18 , C07K2317/565 , G01N2800/2821
摘要： The present inventors successfully produced monoclonal antibodies that are specific to only soluble Aβ oligomers, but do not recognize soluble Aβ monomers, which are physiological molecules. It was demonstrated that the antibodies are useful as diagnostic/therapeutic monoclonal antibodies for Alzheimer's disease.
摘要翻译： 本发明人成功地生产了仅可溶性A＆bgr特异性的单克隆抗体; 低聚物，但不能识别可溶性A＆bgr; 单体，它们是生理分子。 证明该抗体可用作阿尔茨海默病的诊断/治疗单克隆抗体。
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2.发明申请公开(公告)号：US20100028357A1
公开(公告)日：2010-02-04
申请号：US12533348
申请日：2009-07-31
IPC分类号： A61K39/395 , C07K16/42 , G01N33/566 , G01N33/53
CPC分类号： C07K16/18 , A61K2039/505 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , G01N33/6896 , G01N2333/4709 , G01N2800/2821
摘要： The present inventors successfully produced monoclonal antibodies that are specific to only soluble Aβ oligomers, but do not recognize soluble Aβ monomers, which are physiological molecules. It was demonstrated that the antibodies are useful as diagnostic/therapeutic monoclonal antibodies for Alzheimer's disease.
摘要翻译： 本发明人成功地生产了仅可溶性Aβ寡聚物特异性但不识别作为生理分子的可溶性Aβ单体的单克隆抗体。 证明该抗体可用作阿尔茨海默病的诊断/治疗单克隆抗体。
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3.发明申请公开(公告)号：US20110097319A1
公开(公告)日：2011-04-28
申请号：US12851233
申请日：2010-08-05
IPC分类号： A61K39/395 , C07K16/00 , A61P25/28 , G01N33/53
CPC分类号： C07K16/18 , A61K2039/505 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , G01N33/6896 , G01N2333/4709 , G01N2800/2821
摘要： The present inventors successfully produced monoclonal antibodies that are specific to only soluble Aβ oligomers, but do not recognize soluble Aβ monomers, which are physiological molecules. It was demonstrated that the antibodies are useful as diagnostic/therapeutic monoclonal antibodies for Alzheimer's disease.
摘要翻译： 本发明人成功地生产了仅可溶性A＆bgr特异性的单克隆抗体; 低聚物，但不能识别可溶性A＆bgr; 单体，它们是生理分子。 证明该抗体可用作阿尔茨海默病的诊断/治疗单克隆抗体。
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公开(公告)号：US08378081B2
公开(公告)日：2013-02-19
申请号：US12533348
申请日：2009-07-31
IPC分类号： C07K16/18 , C12P21/08 , A61K39/395
CPC分类号： C07K16/18 , A61K2039/505 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , G01N33/6896 , G01N2333/4709 , G01N2800/2821
摘要： The present inventors successfully produced monoclonal antibodies that are specific to only soluble Aβ oligomers, but do not recognize soluble Aβ monomers, which are physiological molecules. It was demonstrated that the antibodies are useful as diagnostic/therapeutic monoclonal antibodies for Alzheimer's disease.
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5.发明申请公开(公告)号：US20120141477A1
公开(公告)日：2012-06-07
申请号：US13369807
申请日：2012-02-09
IPC分类号： A61K39/395 , A61P25/28 , A61P25/00 , C07K16/18 , G01N33/577
CPC分类号： C07K16/18 , A61K39/3955 , A61K2039/505 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/76 , G01N33/6896
摘要： The present inventors successfully produced monoclonal antibodies that are specific to only soluble Aβ oligomers, but do not recognize soluble Aβ monomers, which are physiological molecules. It was demonstrated that the antibodies are useful as diagnostic/therapeutic monoclonal antibodies for Alzheimer's disease.
摘要翻译： 本发明人成功地生产了仅可溶性A＆bgr特异性的单克隆抗体; 低聚物，但不能识别可溶性A＆bgr; 单体，它们是生理分子。 证明该抗体可用作阿尔茨海默病的诊断/治疗单克隆抗体。
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公开(公告)号：US09085614B2
公开(公告)日：2015-07-21
申请号：US13369807
申请日：2012-02-09
IPC分类号： A61K39/395 , G01N33/53 , C07K16/18 , G01N33/68 , A61K39/00
CPC分类号： C07K16/18 , A61K39/3955 , A61K2039/505 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/76 , G01N33/6896
摘要： The present inventors successfully produced monoclonal antibodies that are specific to only soluble Aβ oligomers, but do not recognize soluble Aβ monomers, which are physiological molecules. It was demonstrated that the antibodies are useful as diagnostic/therapeutic monoclonal antibodies for Alzheimer's disease.
摘要翻译： 本发明人成功地生产了仅可溶性A＆bgr特异性的单克隆抗体; 低聚物，但不能识别可溶性A＆bgr; 单体，它们是生理分子。 证明该抗体可用作阿尔茨海默病的诊断/治疗单克隆抗体。
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公开(公告)号：US20100260783A1
公开(公告)日：2010-10-14
申请号：US12762878
申请日：2010-04-19
IPC分类号： A61K39/395 , C07K16/46 , C07K16/18 , A61P25/28 , G01N33/53
CPC分类号： G01N33/6896 , A61K2039/505 , C07K16/18 , C07K2317/565 , G01N2800/2821
摘要： The present inventors successfully produced monoclonal antibodies that are specific to only soluble Aβ oligomers, but do not recognize soluble Aβ monomers, which are physiological molecules. It was demonstrated that the antibodies are useful as diagnostic/therapeutic monoclonal antibodies for Alzheimer's disease.
摘要翻译： 本发明人成功地生产了仅可溶性A＆bgr特异性的单克隆抗体; 低聚物，但不能识别可溶性A＆bgr; 单体，它们是生理分子。 证明该抗体可用作阿尔茨海默病的诊断/治疗单克隆抗体。
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