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    DEBLOCKING FILTERING APPARATUS AND METHOD BASED ON RASTER SCANNING
    2.
    发明申请
    DEBLOCKING FILTERING APPARATUS AND METHOD BASED ON RASTER SCANNING 审中-公开
    基于扫描扫描的解锁滤波器和方法

    公开(公告)号：US20130202048A1

    公开(公告)日：2013-08-08

    申请号：US13596349

    申请日：2012-08-28

    申请人： Doo Hyun KIM ,  Donggyu Sim ,  Do Hyung Kim ,  Joon Ho Song ,  Eun Kyung Ryu ,  Shi Hwa Lee ,  Hyun Ho Jo ,  Jeong Han Seo

    发明人： Doo Hyun KIM ,  Donggyu Sim ,  Do Hyung Kim ,  Joon Ho Song ,  Eun Kyung Ryu ,  Shi Hwa Lee ,  Hyun Ho Jo ,  Jeong Han Seo

    IPC分类号： H04N7/26

    CPC分类号： H04N19/86 ,  H04N19/61

    摘要： A deblocking filtering apparatus and method based on raster scanning is provided. The deblocking filtering apparatus may include a boundary determining unit to determine whether at least one of a vertical edge boundary and a horizontal edge boundary of a block corresponds to at least one of a coding unit (CU) boundary, a transform unit (TU) boundary, and a prediction unit (PU) boundary, a boundary strength (BS) computing unit to compute a BS value for at least one of the vertical edge boundary and the horizontal edge boundary when at least one of the vertical edge boundary and the horizontal edge boundary of the block corresponds to at least one of the CU boundary, the TU boundary, and the PU boundary as a result of the determining, and a filtering performing unit to perform deblocking filtering on at least one of the vertical edge boundary and the horizontal edge boundary.

    摘要翻译： 提供了一种基于光栅扫描的去块滤波装置和方法。 去块滤波装置可以包括边界确定单元，用于确定块的垂直边缘边界和水平边缘边界中的至少一个是否对应于编码单元（CU）边界，变换单元（TU）边界中的至少一个 ，以及预测单元（PU）边界，边界强度（BS）计算单元，用于当垂直边缘边界和水平边缘中的至少一个计算垂直边缘边界和水平边缘边界中的至少一个时的BS值 作为确定的结果，块的边界对应于CU边界，TU边界和PU边界中的至少一个，以及滤波执行单元，用于对垂直边缘边界和水平面中的至少一个进行去块滤波 边界。

    METHOD FOR TREATING A VCAM-1 MEDIATED DISEASE
    4.
    发明申请
    METHOD FOR TREATING A VCAM-1 MEDIATED DISEASE 审中-公开
    治疗VCAM-1介导性疾病的方法

    公开(公告)号：US20100172902A1

    公开(公告)日：2010-07-08

    申请号：US12635392

    申请日：2009-12-10

    申请人： Junho CHUNG ,  Eun Kyung RYU ,  Ji Eun LEE ,  Sukmook LEE

    发明人： Junho CHUNG ,  Eun Kyung RYU ,  Ji Eun LEE ,  Sukmook LEE

    IPC分类号： A61K39/395 ,  A61P35/00 ,  A61P29/00 ,  A61P37/00 ,  A61P37/06 ,  A61P9/10 ,  A61P1/00

    CPC分类号： C07K16/2836 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2319/30

    摘要： A method for treating a VCAM-1 mediated disease comprising administering a therapeutically effective amount of a monoclonal antibody to a patient in need thereof. The monoclonal antibody specifically binds to both human and mouse vascular cell adhesion molecule-1 (VCAM-1). The monoclonal antibody comprises(a) a light chain CDR 1 region defined by SEQ ID NO:5, a light chain CDR 2 region defined by SEQ ID NO:6, and a light chain CDR 3 region defined by SEQ ID NO:7, and (b) a heavy chain CDR 1 region defined by SEQ ID NO:8, a heavy chain CDR 2 region defined by SEQ ID NO:.9 or 11, and a heavy chain CDR 3 region defined by SEQ ID NO:10 or 12.

    摘要翻译： 一种治疗VCAM-1介导的疾病的方法，其包括向有需要的患者施用治疗有效量的单克隆抗体。 单克隆抗体特异性结合人和小鼠血管细胞粘附分子-1（VCAM-1）。 单克隆抗体包含（a）由SEQ ID NO：5定义的轻链CDR1区，由SEQ ID NO：6定义的轻链CDR2区和由SEQ ID NO：7限定的轻链CDR3区， 或（b）由SEQ ID NO：8定义的重链CDR1区域，由SEQ ID NO：.9或11定义的重链CDR2区域和由SEQ ID NO：10定义的重链CDR3区域 12。

    VCAM-1 specific monoclonal antibody
    6.
    发明授权
    VCAM-1 specific monoclonal antibody 失效
    VCAM-1特异性单克隆抗体

    公开(公告)号：US07655417B2

    公开(公告)日：2010-02-02

    申请号：US11756437

    申请日：2007-05-31

    申请人： Junho Chung ,  Ji Eun Lee ,  Eun Kyung Ryu ,  Sukmook Lee

    发明人： Junho Chung ,  Ji Eun Lee ,  Eun Kyung Ryu ,  Sukmook Lee

    IPC分类号： G01N33/53 ,  C12N15/87 ,  C12P21/06 ,  C07K16/00 ,  C07K16/28

    CPC分类号： C07K16/2836 ,  C07K2317/55 ,  C07K2319/30

    摘要： The present invention relates to a monoclonal antibody that specifically binds to vascular cell adhesion molecule-1 (VCAM-1 or CD106). Specifically, the present invention relates to an antibody that specifically binds to both human and mouse vascular cell adhesion molecule-1 (VCAM-1), a method for producing the same, a composition for diagnosis or treatment comprising them and a method for diagnosis or treatment using them. The monoclonal antibody of the present invention is the first recombinant monoclonal antibodies that is specific to human and mouse VCAM-1. In addition, the monoclonal antibody of the present invention shows a strong affinity to VCAM-1 expressed in rat skeletal muscle and porcine endothelial cells as well as human and mouse endothelial cells and is found to strongly inhibit the interaction between leukocytes and activated endothelial cells. Accordingly, the monoclonal antibody of the present invention can inhibit a VCAM-1 mediated adhesion of leukocytes to endothelial cells and potently treat VCAM-1 mediated disease, especially inflammatory disease or cancer.

    摘要翻译： 本发明涉及特异性结合血管细胞粘附分子-1（VCAM-1或CD106）的单克隆抗体。 具体地，本发明涉及特异性结合人和小鼠血管细胞粘附分子-1（VCAM-1）的抗体，其制备方法，包含它们的诊断或治疗组合物以及诊断或诊断方法 治疗使用它们。 本发明的单克隆抗体是人和小鼠VCAM-1特异性的第一种重组单克隆抗体。 此外，本发明的单克隆抗体显示出对大鼠骨骼肌和猪内皮细胞以及人和小鼠内皮细胞中表达的VCAM-1的强亲和力，并且发现其强烈抑制白细胞和活化的内皮细胞之间的相互作用。 因此，本发明的单克隆抗体可以抑制VCAM-1介导的白细胞对内皮细胞的粘附，并且有效治疗VCAM-1介导的疾病，特别是炎性疾病或癌症。

    VCAM-1 SPECIFIC MONOCLONAL ANTIBODY
    7.
    发明申请
    VCAM-1 SPECIFIC MONOCLONAL ANTIBODY 失效
    VCAM-1特异性单克隆抗体

    公开(公告)号：US20070280941A1

    公开(公告)日：2007-12-06

    申请号：US11756437

    申请日：2007-05-31

    申请人： Junho Chung ,  Ji Eun Lee ,  Eun Kyung Ryu ,  Sukmook Lee

    发明人： Junho Chung ,  Ji Eun Lee ,  Eun Kyung Ryu ,  Sukmook Lee

    IPC分类号： A61K39/395 ,  C07K16/28

    CPC分类号： C07K16/2836 ,  C07K2317/55 ,  C07K2319/30

    摘要： The present invention relates to a monoclonal antibody that specifically binds to vascular cell adhesion molecule-1 (VCAM-1 or CD106). Specifically, the present invention relates to an antibody that specifically binds to both human and mouse vascular cell adhesion molecule-1 (VCAM-1), a method for producing the same, a composition for diagnosis or treatment comprising them and a method for diagnosis or treatment using them. The monoclonal antibody of the present invention is the first recombinant monoclonal antibodies that is specific to human and mouse VCAM-1. In addition, the monoclonal antibody of the present invention shows a strong affinity to VCAM-1 expressed in rat skeletal muscle and porcine endothelial cells as well as human and mouse endothelial cells and is found to strongly inhibit the interaction between leukocytes and activated endothelial cells. Accordingly, the monoclonal antibody of the present invention can inhibit a VCAM-1 mediated adhesion of leukocytes to endothelial cells and potently treat VCAM-1 mediated disease, especially inflammatory disease or cancer.

    摘要翻译： 本发明涉及特异性结合血管细胞粘附分子-1（VCAM-1或CD106）的单克隆抗体。 具体地，本发明涉及特异性结合人和小鼠血管细胞粘附分子-1（VCAM-1）的抗体，其制备方法，包含它们的诊断或治疗组合物以及诊断或诊断方法 治疗使用它们。 本发明的单克隆抗体是对人和小鼠VCAM-1特异的第一种重组单克隆抗体。 此外，本发明的单克隆抗体显示出对大鼠骨骼肌和猪内皮细胞以及人和小鼠内皮细胞中表达的VCAM-1的强亲和力，并且发现其强烈抑制白细胞和活化的内皮细胞之间的相互作用。 因此，本发明的单克隆抗体可以抑制VCAM-1介导的白细胞对内皮细胞的粘附，并且有效治疗VCAM-1介导的疾病，特别是炎性疾病或癌症。