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公开(公告)号：US20060135806A1
公开(公告)日：2006-06-22
申请号：US10534867
申请日：2003-11-06
Applicant: Tiziano Scubla , Nevio Francescutti , Fausto Gorassini , Graziano Castaldi
Inventor： Tiziano Scubla , Nevio Francescutti , Fausto Gorassini , Graziano Castaldi
IPC: C07C203/04
CPC classification number: C07C203/04 , C07C201/02
Abstract: A process for the purification of 1,4-butanediol mononitrate from 1,4-butanediol dinitrate and 1,4-butanediol, by selective extraction with solvents is herein disclosed.
Abstract translation: 本文公开了通过溶剂选择性萃取从1,4-丁二醇和1,4-丁二醇纯化1,4-丁二醇单硝酸酯的方法。
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2.发明申请公开(公告)号：US20120142939A1
公开(公告)日：2012-06-07
申请号：US13286421
申请日：2011-11-01
Applicant: Pietro ALLEGRINI , Emanuele ATTOLINO , Alessandro DE MARCO , Fausto GORASSINI , Mario MICHIELETTI
Inventor： Pietro ALLEGRINI , Emanuele ATTOLINO , Alessandro DE MARCO , Fausto GORASSINI , Mario MICHIELETTI
CPC classification number: C07F9/3211 , C07F9/3241 , C07F9/3264
Abstract: The present invention relates to a process for the preparation of intermediates useful in the synthesis of [1[S(R)],2α,4β]-4-cyclohexyl-1-[[[2-methyl-1-oxypropoxy)propoxy](4-phenylbutyl phosphinyl]acetyl]L-proline, and the synthesis thereof, in particular as sodium salt (fosinopril sodium).
Abstract translation: 本发明涉及制备可用于合成[1 [S（R）]，2α，4α-环己基-1 - [[[2-甲基-1-氧丙氧基）丙氧基] ]（4-苯基丁基氧膦基）乙酰基] L-脯氨酸及其合成，特别是作为钠盐（福辛普利钠）。
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公开(公告)号：US20080146830A1
公开(公告)日：2008-06-19
申请号：US12036555
申请日：2008-02-25
Applicant: Nevio FRANCESCUTTI , Tiziano SCUBLA , Fausto GORASSINI , Graziano CASTALDI
Inventor： Nevio FRANCESCUTTI , Tiziano SCUBLA , Fausto GORASSINI , Graziano CASTALDI
IPC: C07C201/00
CPC classification number: C01B21/46 , C07C201/02 , C07C203/04
Abstract: A process for the preparation of compounds of formula HO-A-ONO2 (I) wherein A is a C2-C6 alkylene chain by nitration of the corresponding alkanediols with “stabilised” nitric acid is herein disclosed. The process is safer to operators and allows to obtain advantageous yields on an industrial scale.
Abstract translation: 一种制备式<β的化合物的方法在线式描述=“在线式”中=“铅”→HO-A-ONO 2（I）<α -line-formula description =“In-line Formulas”end =“tail”？>其中A是C 2 -C 6 -C 6亚烷基链，硝化相应的链烷二醇 本文公开了“稳定”硝酸。 该过程对操作员更安全，并允许在工业规模上获得有利的产量。
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公开(公告)号：US07335789B2
公开(公告)日：2008-02-26
申请号：US10534868
申请日：2003-11-06
Applicant: Nevio Francescutti , Tiziano Scubla , Fausto Gorassini , Graziano Castaldi
Inventor： Nevio Francescutti , Tiziano Scubla , Fausto Gorassini , Graziano Castaldi
IPC: C07C201/02 , C07C203/04
CPC classification number: C01B21/46 , C07C201/02 , C07C203/04
Abstract: A process for the preparation of compounds of formula (I): HO-A-ONO2 (I) wherein A is a C2-C6 alkylene chain, the compounds of formula (I) being synthesized by nitration of the corresponding alkanediols with “stabilized” nitric acid is herein disclosed. The process is safer to operators and allows to obtain advantageous yields on an industrial scale.
Abstract translation: 制备式（I）化合物的方法：<？in-line-formula description =“In-line formula”end =“lead”？HO-A-ONO 2（I ）<？in-line-formula description =“In-line Formulas”end =“tail”？>其中A是C 2 -C 6亚烷基链， 本文公开了通过用“稳定”的硝酸硝化相应的链烷二醇合成的式（I）化合物。 该过程对操作员更安全，并允许在工业规模上获得有利的产量。
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公开(公告)号：US07982062B2
公开(公告)日：2011-07-19
申请号：US11853632
申请日：2007-09-11
Applicant: Pietro Allegrini , Tiziano Scubla , Fausto Gorassini , Andrea Finco
Inventor： Pietro Allegrini , Tiziano Scubla , Fausto Gorassini , Andrea Finco
IPC: C07J9/00
CPC classification number: C07J9/005
Abstract: A process for the preparation of high purity cholanic acids, typically in purity equal to or higher than 99%.
Abstract translation: 制备高纯度胆酸的方法，通常纯度等于或高于99％。
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Patent Agency Ranking
公开(公告)号：US20080293961A1
公开(公告)日：2008-11-27
申请号：US12166739
申请日：2008-07-02
Applicant: Tiziano Scubla , Nevio Francescutti , Fausto Gorassini , Graziano Castaldi
Inventor： Tiziano Scubla , Nevio Francescutti , Fausto Gorassini , Graziano Castaldi
IPC: C07C201/02
CPC classification number: C07C203/04 , C07C201/02
Abstract: A process for the purification of 1,4-butanediol mononitrate from 1,4-butanediol dinitrate and 1,4-butanediol, by selective extraction with solvents is herein disclosed.
Abstract translation: 本文公开了通过溶剂选择性萃取从1,4-丁二醇和1,4-丁二醇纯化1,4-丁二醇单硝酸酯的方法。
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公开(公告)号：US20060128983A1
公开(公告)日：2006-06-15
申请号：US10534868
申请日：2003-11-06
Applicant: Nevio Francescutti , Tiziano Scubla , Fausto Gorassini , Graziano Castaldi
Inventor： Nevio Francescutti , Tiziano Scubla , Fausto Gorassini , Graziano Castaldi
IPC: C07C201/02
CPC classification number: C01B21/46 , C07C201/02 , C07C203/04
Abstract: A process for the preparation of compounds of formula HO-A-ONO2 (I) wherein A is a C2-C6 alkylene chain by nitration of the corresponding alkanediols with “stabilised” nitric acid is herein disclosed. The process is safer to operators and allows to obtain advantageous yields on an industrial scale.
Abstract translation: 一种制备式<β的化合物的方法在线式描述=“在线式”中=“铅”→HO-A-ONO 2（I）<α -line-formula description =“In-line Formulas”end =“tail”？>其中A是C 2 -C 6 -C 6亚烷基链，硝化相应的链烷二醇 本文公开了“稳定”硝酸。 该过程对操作员更安全，并允许在工业规模上获得有利的产量。
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公开(公告)号：US07947855B2
公开(公告)日：2011-05-24
申请号：US12166739
申请日：2008-07-02
Applicant: Tiziano Scubla , Nevio Francescutti , Fausto Gorassini , Graziano Castaldi
Inventor： Tiziano Scubla , Nevio Francescutti , Fausto Gorassini , Graziano Castaldi
IPC: C07C27/26 , C07C201/02
CPC classification number: C07C203/04 , C07C201/02
Abstract: A process for the purification of 1,4-butanediol mononitrate from 1,4-butanediol dinitrate and 1,4-butanediol, by selective extraction with solvents is herein disclosed.
Abstract translation: 本文公开了通过溶剂选择性萃取从1,4-丁二醇和1,4-丁二醇纯化1,4-丁二醇单硝酸酯的方法。
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公开(公告)号：US07851649B2
公开(公告)日：2010-12-14
申请号：US12036555
申请日：2008-02-25
Applicant: Nevio Francescutti , Tiziano Scubla , Fausto Gorassini , Graziano Castaldi
Inventor： Nevio Francescutti , Tiziano Scubla , Fausto Gorassini , Graziano Castaldi
IPC: C07C63/00
CPC classification number: C01B21/46 , C07C201/02 , C07C203/04
Abstract: A process for the preparation of compounds of formula HO-A-ONO2 (I) wherein A is a C2-C6 alkylene chain by nitration of the corresponding alkanediols with “stabilized” nitric acid is herein disclosed. The process is safer to operators and allows to obtain advantageous yields on an industrial scale.
Abstract translation: 本文公开了通过用“稳定”的硝酸硝化相应的链烷二醇制备式HO-A-ONO 2（I）的化合物的方法，其中A是C2-C6亚烷基链。 该过程对操作员更安全，并允许在工业规模上获得有利的产量。
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公开(公告)号：US20080064888A1
公开(公告)日：2008-03-13
申请号：US11853632
申请日：2007-09-11
Applicant: Pietro ALLEGRINI , Tiziano SCUBLA , Fausto GORASSINI , Andrea FINCO
Inventor： Pietro ALLEGRINI , Tiziano SCUBLA , Fausto GORASSINI , Andrea FINCO
IPC: C07J9/00
CPC classification number: C07J9/005
Abstract: A process for the preparation of high purity cholanic acids, typically in purity equal to or higher than 99%.
Abstract translation: 制备高纯度胆酸的方法，通常纯度等于或高于99％。
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