公开(公告)号：US20070190575A1

公开(公告)日：2007-08-16

申请号：US11655472

申请日：2007-01-19

申请人： Steven Popoff ,  Fayez Safadi ,  Thomas Owen ,  Steven Smock

发明人： Steven Popoff ,  Fayez Safadi ,  Thomas Owen ,  Steven Smock

IPC分类号： A61K38/18 ,  C07K14/475 ,  G01N33/53 ,  C07H21/04 ,  C12P21/06

CPC分类号： A61K38/1709 ,  C07K14/4705 ,  C07K14/475 ,  G01N33/6893 ,  G01N2800/10 ,  G01N2800/108

摘要： The invention provides osteoactivin proteins and nucleic acid molecules that encode the same, as well as biologically functional expression vectors containing nucleic acid molecules encoding osteoactivin proteins, and antibodies specific for osteoactivin proteins. The invention also provides therapeutic and diagnostic compositions and methods for utilizing the proteins, antibodies, nucleic acids, and vectors of the invention, for example, to modulate bone formation.

摘要翻译： 本发明提供了生物活性蛋白和编码相同的核酸分子以及含有编码骨诱导蛋白的核酸分子的生物功能性表达载体和对骨质疏醇蛋白特异性的抗体。 本发明还提供了用于利用本发明的蛋白质，抗体，核酸和载体例如调节骨形成的治疗和诊断组合物和方法。

公开(公告)号：US07226904B2

公开(公告)日：2007-06-05

申请号：US11190665

申请日：2005-07-27

申请人： Gary B. Schneider ,  Steven N. Popoff ,  Fayez Safadi

发明人： Gary B. Schneider ,  Steven N. Popoff ,  Fayez Safadi

IPC分类号： A61K38/14

CPC分类号： C07K7/08 ,  A61K38/00 ,  C07K5/0821 ,  C07K5/1024 ,  C07K9/005 ,  C07K14/47 ,  C07K14/51 ,  C07K14/57

摘要： Agents for promoting bone deposition and growth in a mammalian subject. The agents are O-glycosylated and non-glycosylated peptides that are derived from vitamin D binding protein, collectively referred to hereinafter as “DBP” peptides. The DBP peptides are from 3 to 18, preferably from 4 to 14 amino acids in length and comprise a sequence which is at least 80% identical, preferably at least 90% identical to the amino acid sequence of a fragment contained within domain III of DBP. Methods for promoting bone deposition in a subject in need of the same are also provided. The methods comprise administering to the subject a therapeutically effective quantity of an agent selected from the group consisting of an activated form of vitamin D binding protein referred to hereinafter as “ADBP”, one or more DBP peptides, and combinations thereof. The agents may be administered locally or systemically.

摘要翻译： 促进哺乳动物受试者骨沉积和生长的药剂。 这些试剂是衍生自维生素D结合蛋白的O-糖基化和非糖基化肽，统称为“DBP”肽。 DBP肽的长度为3至18，优选4至14个氨基酸，并且包含与DBP的结构域III内含有的片段的氨基酸序列至少80％相同，优选至少90％相同的序列 。 还提供了在需要相同的受试者中促进骨沉积的方法。 所述方法包括向受试者施用治疗有效量的选自下文称为“ADBP”的活化形式的维生素D结合蛋白，一种或多种DBP肽及其组合的药剂。 这些试剂可以局部或全身施用。

公开(公告)号：US07038010B2

公开(公告)日：2006-05-02

申请号：US10045673

申请日：2001-11-09

申请人： Gary B. Schneider ,  Steven N. Popoff ,  Fayez Safadi

发明人： Gary B. Schneider ,  Steven N. Popoff ,  Fayez Safadi

IPC分类号： A61K38/14

CPC分类号： C07K7/08 ,  A61K38/00 ,  C07K5/0821 ,  C07K5/1024 ,  C07K9/005 ,  C07K14/47 ,  C07K14/51 ,  C07K14/57

摘要： Agents for promoting bone deposition and growth in a mammalian subject. The agents are O-glycosylated and non-glycosylated peptides that are derived from vitamin D binding protein, collectively referred to hereinafter as “DBP” peptides. The DBP peptides are from 3 to 18, preferably from 4 to 14 amino acids in length and comprise a sequence which is at least 80% identical, preferably at least 90% identical to the amino acid sequence of a fragment contained within domain III of DBP. Methods for promoting bone deposition in a subject in need of the same are also provided. The methods comprise administering to the subject a therapeutically effective quantity of an agent selected from the group consisting of an activated form of vitamin D binding protein referred to hereinafter as “ADBP”, one or more DBP peptides, and combinations thereof. The agents may be administered locally or systemically.

公开(公告)号：US20050261172A1

公开(公告)日：2005-11-24

申请号：US11190665

申请日：2005-07-27

申请人： Gary Schneider ,  Steven Popoff ,  Fayez Safadi

发明人： Gary Schneider ,  Steven Popoff ,  Fayez Safadi

IPC分类号： A61K38/00 ,  C07K5/097 ,  C07K5/117 ,  C07K7/08 ,  C07K9/00 ,  C07K14/47 ,  C07K14/51 ,  C07K14/57 ,  A61K38/14 ,  A61K38/10

CPC分类号： C07K7/08 ,  A61K38/00 ,  C07K5/0821 ,  C07K5/1024 ,  C07K9/005 ,  C07K14/47 ,  C07K14/51 ,  C07K14/57

摘要： Agents for promoting bone deposition and growth in a mammalian subject. The agents are O-glycosylated and non-glycosylated peptides that are derived from vitamin D binding protein, collectively referred to hereinafter as “DBP” peptides. The DBP peptides are from 3 to 18, preferably from 4 to 14 amino acids in length and comprise a sequence which is at least 80% identical, preferably at least 90% identical to the amino acid sequence of a fragment contained within domain III of DBP. Methods for promoting bone deposition in a subject in need of the same are also provided. The methods comprise administering to the subject a therapeutically effective quantity of an agent selected from the group consisting of an activated form of vitamin D binding protein referred to hereinafter as “ADBP”, one or more DBP peptides, and combinations thereof. The agents may be administered locally or systemically.

摘要翻译： 促进哺乳动物受试者骨沉积和生长的药剂。 这些试剂是衍生自维生素D结合蛋白的O-糖基化和非糖基化肽，统称为“DBP”肽。 DBP肽的长度为3至18，优选4至14个氨基酸，并且包含与DBP的结构域III内含有的片段的氨基酸序列至少80％相同，优选至少90％相同的序列 。 还提供了在需要相同的受试者中促进骨沉积的方法。 所述方法包括向受试者施用治疗有效量的选自下文称为“ADBP”的活化形式的维生素D结合蛋白，一种或多种DBP肽及其组合的药剂。 这些试剂可以局部或全身施用。

公开(公告)号：US20050196772A1

公开(公告)日：2005-09-08

申请号：US10978758

申请日：2004-11-01

申请人： Steven Popoff ,  Fayez Safadi ,  Thomas Owen ,  Steven Smock

发明人： Steven Popoff ,  Fayez Safadi ,  Thomas Owen ,  Steven Smock

IPC分类号： A61K38/00 ,  C07K14/47 ,  C12N15/19 ,  C12Q1/68 ,  C07H21/04 ,  C12N9/64 ,  C12N15/09 ,  C12P21/06

CPC分类号： A61K38/1709 ,  C07K14/4705 ,  C07K14/475 ,  G01N33/6893 ,  G01N2800/10 ,  G01N2800/108

摘要： The invention provides osteoactivin proteins and nucleic acid molecules that encode the same, as well as biologically functional expression vectors containing nucleic acid molecules encoding osteoactivin proteins, and antibodies specific for osteoactivin proteins. The invention also provides therapeutic and diagnostic compositions and methods for utilizing the proteins, antibodies, nucleic acids, and vectors of the invention, for example, to modulate bone formation.

摘要翻译： 本发明提供了生物活性蛋白和编码相同的核酸分子以及含有编码骨诱导蛋白的核酸分子的生物功能性表达载体和对骨质疏醇蛋白特异性的抗体。 本发明还提供了用于利用本发明的蛋白质，抗体，核酸和载体例如调节骨形成的治疗和诊断组合物和方法。