摘要:
The present invention relates to an antigenically effective peptide comprising, from the amino to the carboxylic terminal, the amino acid sequence: G P P W W P P I C D P P Q P S K T Q G Q S X1 G Q S X2 G X3 G X4 G X5 G X6 G X7 G K G K S X8 D K Q X9 K P G G P W X10 P E P (SEQ ID No. 1), wherein the amino acids X1-X10 are selected independently from an arginine residue or a citrulline residue and at least one of X1-X10 is a citrulline residue, or a functional fragment thereof and uses thereof.
摘要翻译:本发明涉及一种抗原性有效的肽,其包含从氨基到羧基末端的氨基酸序列:GPPWWPPICDPPQPSKTQGQS X1 GQS X2 G X3 G X4 G X5 G X6 G X7 GKGKS X8 DKQ X9 KPGGPW X10 PEP(SEQ ID No. 1),其中氨基酸X1-X10独立地选自精氨酸残基或瓜氨酸残基,并且X 1 -X 10中的至少一个是瓜氨酸残基或其功能片段及其用途。
摘要:
The present invention refers to citrullinated synthetic peptides derived from the histone H4 protein and their use in the diagnosis of autoimmune diseases,particularly Rheumatoid Arthritis (RA).
摘要:
The present invention relates to an antigenically effective peptide comprising, from the amino to the carboxylic terminal, the amino acid sequence: G P P W W P P I C D P P Q P S K T Q G Q S X1 G Q S X2 G X3 G X4 G X5 G X6 G X7 G K G K S X8 D K Q X9 K P G G P W X10 P E P (SEQ ID No. 1), wherein the amino acids X1-X10 are selected independently from an arginine residue or a citrulline residue and at least one of X1-X10 is a citrulline residue, or a functional fragment thereof and uses thereof.
摘要翻译:本发明涉及一种抗原性有效的肽,其包含从氨基到羧基末端的氨基酸序列:GPPWWPPICDPPQPSKTQGQS X1 GQS X2 G X3 G X4 G X5 G X6 G X7 GKGKS X8 DKQ X9 KPGGPW X10 PEP(SEQ ID No. 1),其中氨基酸X1-X10独立地选自精氨酸残基或瓜氨酸残基,并且X 1 -X 10中的至少一个是瓜氨酸残基或其功能片段及其用途。
摘要:
The present invention refers peptides and methods for the identification of diagnostic antibodies in auto-immune diseases such as Systemic Lupus Erythematosus (SLE), and therefore useful tools for diagnosis or therapeutic treatment of SLE.