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    IMPROVED AMINO ACID SEQUENCES DIRECTED AGAINST IL-6R AND POLYPEPTIDES COMPRISING THE SAME FOR THE TREATMENT OF IL-6R RELATED DISEASES AND DISORDERS
    3.
    发明申请
    IMPROVED AMINO ACID SEQUENCES DIRECTED AGAINST IL-6R AND POLYPEPTIDES COMPRISING THE SAME FOR THE TREATMENT OF IL-6R RELATED DISEASES AND DISORDERS 审中-公开
    改进的针对IL-6R和包含IL-6R相关疾病和疾病治疗相关疾病的多肽的氨基酸序列

    公开(公告)号：US20120171209A1

    公开(公告)日：2012-07-05

    申请号：US13263223

    申请日：2010-04-12

    申请人： Veerle Compernolle ,  Francis Descamps

    发明人： Veerle Compernolle ,  Francis Descamps

    IPC分类号： A61K39/395 ,  C12N15/13 ,  C12N5/10 ,  C12P21/02 ,  C12N1/21 ,  C07K16/24 ,  C12N1/19

    CPC分类号： C07K16/2866 ,  C07K2317/22 ,  C07K2317/24 ,  C07K2317/569 ,  C07K2317/76 ,  C07K2317/92

    摘要： The present invention relates to amino acid sequences that are directed against/and or that can specifically bind (as defined herein) Interleukin-6 Receptor (IL-6R), as well as to compounds or constructs, and in particular proteins and polypeptides, that comprise or essentially consist of one or more such amino acid sequences. In a specific aspect, the present invention provides amino acid sequences and polypeptides that are capable of binding to two or more different antigenic determinants, epitopes, parts, domains of IL-6R, also referred to as “multiparatopic” (such as e.g. “biparatopic” or “triparatopic”, etc.) amino acid sequences and polypeptides. The invention also relates to nucleic acids encoding such amino acid sequences and polypeptides, methods for preparing such amino acid sequences and polypeptides, host cells expressing or capable of expressing such amino acid sequences or polypeptides, compositions, and in particular to pharmaceutical compositions, that comprise such amino acid sequences, polypeptides, nucleic acids and/or host cells and to uses of such amino acid sequences or polypeptides, nucleic acids, host cells and/or compositions, in particular for prophylactic, therapeutic or diagnostic purposes.

    摘要翻译： 本发明涉及针对和/或可以特异性结合（如本文所定义）白细胞介素-6受体（IL-6R）以及化合物或构建体，特别是蛋白质和多肽的氨基酸序列，其中 包含或基本上由一个或多个这样的氨基酸序列组成。 在具体方面，本发明提供能够结合两种或更多种不同抗原决定簇，表位，部分，IL-6R的结构域（也称为“多功能性”）的氨基酸序列和多肽（例如“双互补位点” “或”三叠氮化“等）氨基酸序列和多肽。 本发明还涉及编码这种氨基酸序列和多肽的核酸，制备这种氨基酸序列和多肽的方法，表达或能够表达这种氨基酸序列或多肽的宿主细胞，组合物，特别是药物组合物，其包含 这些氨基酸序列，多肽，核酸和/或宿主细胞，以及这些氨基酸序列或多肽，核酸，宿主细胞和/或组合物的用途，特别是用于预防，治疗或诊断目的。