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    Anti-IL-6R polypeptides and pharmaceutical compositions thereof
    3.
    发明授权
    Anti-IL-6R polypeptides and pharmaceutical compositions thereof 有权
    抗IL-6R多肽及其药物组合物

    公开(公告)号：US08748581B2

    公开(公告)日：2014-06-10

    申请号：US13263179

    申请日：2010-04-12

    申请人： Els Anna Alice Beirnaert ,  Cedric Jozef Neotere Ververken ,  Joost Alexander Kolkman ,  Maarten Van Roy

    发明人： Els Anna Alice Beirnaert ,  Cedric Jozef Neotere Ververken ,  Joost Alexander Kolkman ,  Maarten Van Roy

    IPC分类号： C07K16/00 ,  A61K39/395 ,  A61K39/00

    CPC分类号： C07K16/2866 ,  A61K39/3955 ,  A61K2039/505 ,  C07K16/18 ,  C07K16/4283 ,  C07K16/468 ,  C07K2317/22 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/35 ,  C07K2317/565 ,  C07K2317/569 ,  C07K2317/64 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94 ,  C12N15/09

    摘要： The present invention relates to amino acid sequences that are directed against/and or that can specifically bind Interleukin-6 Receptor (IL-6R) with improved affinity and/or avidity, and/or that have an improved efficacy and/or potency, and which are capable of (partially, or preferably totally) blocking the IL-6/IL-6R interaction and/or inhibit signalization through IL-6, IL-6R and/or the IL-6/IL-6R complex. The invention further relates to compounds or constructs, and in particular proteins and polypeptides, that comprise or essentially consist of one or more such amino acid sequences. The invention also relates to nucleic acids encoding such amino acid sequences and polypeptides, to methods for preparing such amino acid sequences and polypeptides, to host cells expressing or capable of expressing such amino acid sequences or polypeptides, to compositions, and in particular to pharmaceutical compositions, that comprise such amino acid sequences, polypeptides, nucleic acids and/or host cells, and to uses of such amino acid sequences or polypeptides, nucleic acids, host cells and/or compositions, in particular for prophylactic, therapeutic or diagnostic purposes.

    摘要翻译： 本发明涉及与改善的亲和力和/或亲合力有关的和/或可特异性结合白细胞介素-6受体（IL-6R）的氨基酸序列和/或具有改善的功效和/或效力的氨基酸序列，和 其能够（部分或优选全部）阻断IL-6 / IL-6R相互作用和/或通过IL-6，IL-6R和/或IL-6 / IL-6R复合物抑制信号传导。 本发明还涉及包含或基本上由一个或多个这样的氨基酸序列组成的化合物或构建体，特别是蛋白质和多肽。 本发明还涉及编码这种氨基酸序列和多肽的核酸，制备此类氨基酸序列和多肽的方法，将表达或能够表达该氨基酸序列或多肽的细胞宿主给组合物，特别是药物组合物 包括这样的氨基酸序列，多肽，核酸和/或宿主细胞，以及这些氨基酸序列或多肽，核酸，宿主细胞和/或组合物的用途，特别是用于预防，治疗或诊断目的。

    VON WILLEBRAND FACTOR SPECIFIC BINDING AGENTS AND USES THEREOF
    4.
    发明申请
    VON WILLEBRAND FACTOR SPECIFIC BINDING AGENTS AND USES THEREOF 审中-公开
    VON WILLEBRAND因子特异性结合剂及其用途

    公开(公告)号：US20120321640A1

    公开(公告)日：2012-12-20

    申请号：US13512126

    申请日：2010-11-25

    申请人： Maarten Van Roy ,  Hans Ulrichts

    发明人： Maarten Van Roy ,  Hans Ulrichts

    IPC分类号： A61K39/395 ,  A61P11/00 ,  A61P9/10 ,  C07K16/36 ,  A61P7/02

    CPC分类号： C07K16/36 ,  A61K39/3955 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/569 ,  C07K2319/00 ,  A61K2300/00

    摘要： The invention provides new uses, compositions and methods of administration for specific binding agents to von Wiliebrand Factor (vWF) in patients with thromboembolic disorders and in particular new combined uses with thrombolytic agents such as tissue plasminogen activator in patients with thromboembolic disorders such as e.g. ischemic stroke. Furthermore, a new group of vWF binding agents and an improved Middle Cerebral Artery Thrombosis Model in guinea pigs to study the effects of stroke such as ischemia (oxygen and glucose depriviation) and hemorrhage (bleeding), in particular hemorrhage, are provided.

    摘要翻译： 本发明提供了血栓栓塞障碍患者中von Wiliebrand因子（vWF）的特异性结合剂的新用途，组合物和方法，特别是具有血栓栓塞障碍患者溶栓剂如组织纤溶酶原激活剂的新联合用途，例如血栓栓塞症。 缺血性中风。 此外，提供了一组新的vWF结合剂和改进的豚鼠中脑动脉血栓形成模型，以研究中风的影响，如缺血（氧气和葡萄糖剥夺）和出血（出血），特别是出血。