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公开(公告)号：US20110262438A1
公开(公告)日：2011-10-27
申请号：US13073044
申请日：2011-03-28
申请人： Francis Descamps , Maria Gonzalez Pajuelo , Pascal Gerard Merchiers , Catelijne Stortelers , Peter Vanlandschoot , Philippe Van Rompaey , Martine Smit , Regorius Leurs , David Andre Baptiste Maussang Detaille
发明人： Francis Descamps , Maria Gonzalez Pajuelo , Pascal Gerard Merchiers , Catelijne Stortelers , Peter Vanlandschoot , Philippe Van Rompaey , Martine Smit , Regorius Leurs , David Andre Baptiste Maussang Detaille
IPC分类号： A61K39/395 , C12N15/13 , C12P21/08 , A61P35/00 , A61P17/06 , A61P25/00 , A61P29/00 , A61P11/06 , A61P9/10 , A61P37/06 , C07K16/28 , A61P25/28
CPC分类号： C07K16/2866 , A61K39/39558 , A61K2039/505 , C07K2317/22 , C07K2317/33 , C07K2317/565 , C07K2317/569 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to particular polypeptides, nucleic acids encoding such polypeptides; to methods for preparing such polypeptides; to host cells expressing or capable of expressing such polypeptides; to compositions and in particular to pharmaceutical compositions that comprise such polypeptides, for prophylactic, therapeutic or diagnostic purposes.
摘要翻译： 本发明涉及特定的多肽，编码这种多肽的核酸; 制备这种多肽的方法; 以宿主表达或能够表达这种多肽的细胞; 组合物，特别是涉及用于预防，治疗或诊断目的的包含这种多肽的药物组合物。
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公开(公告)号：US08937164B2
公开(公告)日：2015-01-20
申请号：US13073044
申请日：2011-03-28
申请人： Francis Descamps , Maria Gonzalez Pajuelo , Pascal Gerard Merchiers , Catelijne Stortelers , Peter Vanlandschoot , Philippe Van Rompaey , Martine Smit , Regorius Leurs , David Andre Baptiste Maussang Detaille
发明人： Francis Descamps , Maria Gonzalez Pajuelo , Pascal Gerard Merchiers , Catelijne Stortelers , Peter Vanlandschoot , Philippe Van Rompaey , Martine Smit , Regorius Leurs , David Andre Baptiste Maussang Detaille
IPC分类号： C07K16/28
CPC分类号： C07K16/2866 , A61K39/39558 , A61K2039/505 , C07K2317/22 , C07K2317/33 , C07K2317/565 , C07K2317/569 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to particular polypeptides, nucleic acids encoding such polypeptides; to methods for preparing such polypeptides; to host cells expressing or capable of expressing such polypeptides; to compositions and in particular to pharmaceutical compositions that comprise such polypeptides, for prophylactic, therapeutic or diagnostic purposes.
摘要翻译： 本发明涉及特定的多肽，编码这种多肽的核酸; 制备这种多肽的方法; 以宿主表达或能够表达这种多肽的细胞; 组合物，特别是涉及用于预防，治疗或诊断目的的包含这种多肽的药物组合物。
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公开(公告)号：US20150158948A9
公开(公告)日：2015-06-11
申请号：US14008011
申请日：2012-03-28
申请人： Francis Descamps , David André Baptiste Maussang-Detaille , Maarten Van Roy , Regorius Leurs , Maria Gonzalez Pajuelo , Pascal Gerard Merchiers , Martine Smit , Catelijne Stortelers , Philippe Van Rompaey , Peter Vanlandschoot
发明人： Francis Descamps , David André Baptiste Maussang-Detaille , Maarten Van Roy , Regorius Leurs , Maria Gonzalez Pajuelo , Pascal Gerard Merchiers , Martine Smit , Catelijne Stortelers , Philippe Van Rompaey , Peter Vanlandschoot
IPC分类号： C07K16/28
CPC分类号： C07K16/2866 , A61K2039/507 , C07K2317/22 , C07K2317/31 , C07K2317/33 , C07K2317/569 , C07K2317/76 , C07K2319/31
摘要： The present invention relates to particular polypeptides, nucleic acids encoding such polypeptides; to methods for preparing such polypeptides; to host cells expressing or capable of expressing such polypeptides; to compositions and in particular to pharmaceutical compositions that comprise such polypeptides, for prophylactic, therapeutic or diagnostic purposes. In particular, the present invention provides immunoglobulin single variable domains inhibiting CXCR7 mediated tumour growth.
摘要翻译： 本发明涉及特定的多肽，编码这种多肽的核酸; 制备这种多肽的方法; 以宿主表达或能够表达这种多肽的细胞; 组合物，特别是涉及用于预防，治疗或诊断目的的包含这种多肽的药物组合物。 特别地，本发明提供了抑制CXCR7介导的肿瘤生长的免疫球蛋白单可变结构域。
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公开(公告)号：US20140227270A1
公开(公告)日：2014-08-14
申请号：US14008011
申请日：2012-03-28
申请人： Francis Descamps , David André Baptiste Maussang-Detaille , Maarten Van Roy , Regorius Leurs , Maria Gonzalez Pajuelo , Pascal Gerard Merchiers , Martine Smit , Catelijne Stortelers , Philippe Van Rompaey , Peter Vanlandschoot
发明人： Francis Descamps , David André Baptiste Maussang-Detaille , Maarten Van Roy , Regorius Leurs , Maria Gonzalez Pajuelo , Pascal Gerard Merchiers , Martine Smit , Catelijne Stortelers , Philippe Van Rompaey , Peter Vanlandschoot
IPC分类号： C07K16/28
CPC分类号： C07K16/2866 , A61K2039/507 , C07K2317/22 , C07K2317/31 , C07K2317/33 , C07K2317/569 , C07K2317/76 , C07K2319/31
摘要： The present invention relates to particular polypeptides, nucleic acids encoding such polypeptides; to methods for preparing such polypeptides; to host cells expressing or capable of expressing such polypeptides; to compositions and in particular to pharmaceutical compositions that comprise such polypeptides, for prophylactic, therapeutic or diagnostic purposes. In particular, the present invention provides immunoglobulin single variable domains inhibiting CXCR7 mediated tumour growth.
摘要翻译： 本发明涉及特定的多肽，编码这种多肽的核酸; 制备这种多肽的方法; 以宿主表达或能够表达这种多肽的细胞; 组合物，特别是涉及用于预防，治疗或诊断目的的包含这种多肽的药物组合物。 特别地，本发明提供了抑制CXCR7介导的肿瘤生长的免疫球蛋白单可变结构域。
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5.发明申请AMINO ACID SEQUENCES DIRECTED AGAINST VASCULAR ENDOTHELIAL GROWTH FACTOR AND POLYPEPTIDES COMPRISING THE SAME FOR THE TREATMENT OF CONDITIONS AND DISEASES CHARACTERIZED BY EXCESSIVE AND/OR PATHOLOGICAL ANGIOGENESIS OR NEOVASCULARIZATION 审中-公开指导血管内皮生长因子的氨基酸序列和包含与治疗由过度和/或病理性血管生成或新生血管形成的病症和疾病相关的多肽的氨基酸序列公开(公告)号：US20100120681A1
公开(公告)日：2010-05-13
申请号：US12523256
申请日：2008-02-21
CPC分类号： C07K16/22 , C07K2317/22 , C07K2317/569 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to amino acid sequences that are directed against vascular endothelial growth factor (VEGF), as well as to compounds or constructs, and in particular proteins and polypeptides, that comprise or essentially consist of one or more such amino acid sequences. The amino acid sequences, compounds and constructs can be used for prophylactic, therapeutic or diagnostic purposes, such as for the treatment of conditions and diseases characterized by excessive and/or pathological angiogenesis or neovascularization.
摘要翻译： 本发明涉及针对血管内皮生长因子（VEGF）以及包含或基本上由一个或多个这样的氨基酸序列组成的化合物或构建体，特别是蛋白质和多肽的氨基酸序列。 氨基酸序列，化合物和构建体可用于预防，治疗或诊断目的，例如用于治疗以过度和/或病理性血管生成或新生血管形成为特征的病症和疾病。
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6.发明申请AMINO ACID SEQUENCES DIRECTED AGAINST VASCULAR ENDOTHELIAL GROWTH FACTOR AND POLYPEPTIDES COMPRISING THE SAME FOR THE TREATMENT OF CONDITIONS AND DISEASES CHARACTERIZED BY EXCESSIVE AND/OR PATHOLOGICAL ANGIOGENESIS OR NEOVASCULARIZATION 审中-公开指导血管内皮生长因子的氨基酸序列和包含与治疗由过度和/或病理性血管生成或新生血管形成的病症和疾病相关的多肽的氨基酸序列公开(公告)号：US20110118185A9
公开(公告)日：2011-05-19
申请号：US12523256
申请日：2008-02-21
CPC分类号： C07K16/22 , C07K2317/22 , C07K2317/569 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to amino acid sequences that are directed against vascular endothelial growth factor (VEGF), as well as to compounds or constructs, and in particular proteins and polypeptides, that comprise or essentially consist of one or more such amino acid sequences. The amino acid sequences, compounds and constructs can be used for prophylactic, therapeutic or diagnostic purposes, such as for the treatment of conditions and diseases characterized by excessive and/or pathological angiogenesis or neovascularization.
摘要翻译： 本发明涉及针对血管内皮生长因子（VEGF）以及包含或基本上由一个或多个这样的氨基酸序列组成的化合物或构建体，特别是蛋白质和多肽的氨基酸序列。 氨基酸序列，化合物和构建体可用于预防，治疗或诊断目的，例如用于治疗以过度和/或病理性血管生成或新生血管形成为特征的病症和疾病。
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7.发明授权Methods compositions and compound assays for inhibiting amyloid-beta protein production 有权用于抑制淀粉样蛋白β蛋白生产的方法组合物和化合物测定法公开(公告)号：US07910320B2
公开(公告)日：2011-03-22
申请号：US12190888
申请日：2008-08-13
IPC分类号： G01N33/53 , G01N33/542 , G01N33/566 , G01N33/567 , C12P21/00 , C12P21/06 , C12Q1/66
CPC分类号： C12Q1/37 , G01N33/566 , G01N33/6896 , G01N2333/4709 , G01N2333/726 , G01N2500/00 , G01N2800/2821
摘要： A method for identifying compounds that inhibit amyloid-beta precursor protein processing in cells, comprising contacting a test compound with a GPCR polypeptide, or fragment thereof, and measuring a compound-GPCR property related to the production of amyloid-beta peptide. Cellular assays of the method measure indicators including second messenger and/or amyloid beta peptide levels. Therapeutic methods, and pharmaceutical compositions including effective amyloid-beta precursor processing-inhibiting amounts of GPCR expression inhibitors, are useful for treating conditions involving cognitive impairment such as Alzheimers Disease.
摘要翻译： 鉴定抑制细胞中淀粉样蛋白β前体蛋白加工的化合物的方法，包括使测试化合物与GPCR多肽或其片段接触，并测量与淀粉状蛋白-β肽的产生相关的化合物-GPCR性质。 该方法的细胞测定法测量包括第二信使和/或淀粉样蛋白β肽水平的指标。 包括有效的淀粉样蛋白-β前体加工抑制量的GPCR表达抑制剂的治疗方法和药物组合物可用于治疗涉及认知障碍的疾病如阿尔茨海默病。
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8.发明申请Methods, Compositions and Compound Assays for Inhibiting Amyloid-Beta Protein production 有权用于抑制淀粉样蛋白β蛋白生产的方法，组合物和化合物分析公开(公告)号：US20090005262A1
公开(公告)日：2009-01-01
申请号：US12190888
申请日：2008-08-13
CPC分类号： C12Q1/37 , G01N33/566 , G01N33/6896 , G01N2333/4709 , G01N2333/726 , G01N2500/00 , G01N2800/2821
摘要： A method for identifying compounds that inhibit amyloid-beta precursor protein processing in cells, comprising contacting a test compound with a GPCR polypeptide, or fragment thereof, and measuring a compound-GPCR property related to the production of amyloid-beta peptide. Cellular assays of the method measure indicators including second messenger and/or amyloid beta peptide levels. Therapeutic methods, and pharmaceutical compositions including effective amyloid-beta precursor processing-inhibiting amounts of GPCR expression inhibitors, are useful for treating conditions involving cognitive impairment such as Alzheimers Disease.
摘要翻译： 鉴定抑制细胞中淀粉样蛋白β前体蛋白加工的化合物的方法，包括使测试化合物与GPCR多肽或其片段接触，并测量与淀粉状蛋白-β肽的产生相关的化合物-GPCR性质。 该方法的细胞测定法测量包括第二信使和/或淀粉样蛋白β肽水平的指标。 包括有效的淀粉样蛋白-β前体加工抑制量的GPCR表达抑制剂的治疗方法和药物组合物可用于治疗涉及认知障碍的疾病如阿尔茨海默病。
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9.发明授权Methods for identifying a compound that inhibits the procession of amyloid-beta protein production in a mammalian cell expressing APP and overexpressing a G-protein coupled receptor in the cell 失效用于鉴定抑制表达APP的哺乳动物细胞中淀粉样蛋白-β蛋白产生的过程并在细胞中过表达G蛋白偶联受体的化合物的方法公开(公告)号：US07429459B2
公开(公告)日：2008-09-30
申请号：US11110274
申请日：2005-04-20
IPC分类号： G01N33/53 , G01N33/542 , G01N33/566 , C12P21/06 , C12P21/04
CPC分类号： C12Q1/37 , G01N33/566 , G01N33/6896 , G01N2333/4709 , G01N2333/726 , G01N2500/00 , G01N2800/2821
摘要： A method for identifying compounds that inhibit amyloidal-beta precursor protein processing in cells, comprising contacting a test compound with a GPCR polypeptide, or fragment thereof, and measuring a compound-GPCR property related to the production of amyloidal-beta peptide. Cellular assays of the method measure indicators including second messenger and/or amyloid beta peptide levels. Therapeutic methods,and pharmaceutical compositions including effective amyloidal-beta precursor processing-inhibiting amounts of GPCR expression inhibitors, are useful for treating conditions involving cognitive impairment such as Alzheimers Disease.
摘要翻译： 用于鉴定抑制细胞中淀粉样蛋白β前体蛋白加工的化合物的方法，包括使测试化合物与GPCR多肽或其片段接触，并测量与淀粉样蛋白-β肽的产生相关的化合物-GPCR性质。 该方法的细胞测定法测量包括第二信使和/或淀粉样蛋白β肽水平的指标。 包括有效淀粉样蛋白β前体加工抑制量的GPCR表达抑制剂的治疗方法和药物组合物可用于治疗涉及认知障碍的疾病如阿尔茨海默病。
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