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    Crystalline form of gatifloxacin
    1.
    发明申请
    Crystalline form of gatifloxacin 审中-公开
    加替沙星结晶形式

    公开(公告)号：US20070032505A1

    公开(公告)日：2007-02-08

    申请号：US10573329

    申请日：2004-11-05

    申请人： Cosme Gomez ,  Javier Villasante Prieto ,  Francisco Palomo Nicolau

    发明人： Cosme Gomez ,  Javier Villasante Prieto ,  Francisco Palomo Nicolau

    IPC分类号： A61K31/496 ,  C07D403/02

    CPC分类号： C07D215/56 ,  A61K31/496

    摘要： The present invention relates to a crystalline form of gatifloxacin obtainable by a process that comprises recrystallisation of the crude gatifloxacin in methanol and which is stable with a water content ranging between 2.5 and 4.5% by weight, to a process for preparing it and to the use thereof as an active substance in the preparation of pharmaceutical formulations.

    摘要翻译： 本发明涉及加替沙星的结晶形式，其可通过以下方法获得，该方法包括将粗加替沙星在甲醇中重结晶，并且其水含量在2.5至4.5重量％之间是稳定的，其制备方法和用途 作为药物制剂的制备中的活性物质。

    Addition salts of azithromycin and citric acid and process for preparing them
    2.
    发明申请
    Addition salts of azithromycin and citric acid and process for preparing them 审中-公开
    阿奇霉素和柠檬酸的加成盐及其制备方法

    公开(公告)号：US20070021359A1

    公开(公告)日：2007-01-25

    申请号：US10558801

    申请日：2004-05-26

    申请人： Antonio Cosme Gomez ,  Francisco Palomo Nicolau

    发明人： Antonio Cosme Gomez ,  Francisco Palomo Nicolau

    IPC分类号： A61K31/7052 ,  C07H17/08

    CPC分类号： C07H17/08

    摘要： Said addition salts have a molar ratio between azithromycin and citric acid such as to provide a pH comprised between 4.0 and 8.0 in a 10% aqueous solution. The process for preparing said salts comprises: a) dissolving azithromycin in a solvent or mixture of solvents; b) adding citric acid; and c) isolating the product obtained by crystallisation. The addition salts of azithromycin and citric acid are stable and soluble in aqueous medium, being useful antibacterial and antiprotozoan agents.

    摘要翻译： 所述加成盐具有阿奇霉素和柠檬酸之间的摩尔比，以便在10％水溶液中提供4.0-8.0的pH。 制备所述盐的方法包括：a）将阿奇霉素溶解在溶剂或溶剂混合物中; b）加入柠檬酸; 和c）分离通过结晶获得的产物。 阿奇霉素和柠檬酸的加成盐是稳定和可溶于水性介质，是有用的抗细菌和抗原生动物剂。

    Process For Obtaining Levofloxacin Free From Salts
    6.
    发明申请
    Process For Obtaining Levofloxacin Free From Salts 审中-公开
    从盐中获得左氧氟沙星的方法

    公开(公告)号：US20090069560A1

    公开(公告)日：2009-03-12

    申请号：US11813146

    申请日：2005-12-15

    申请人： Francisco Palomo Nicolau ,  Antonio Cosme Gomez ,  Rafael Martin Sanchez

    发明人： Francisco Palomo Nicolau ,  Antonio Cosme Gomez ,  Rafael Martin Sanchez

    IPC分类号： C07D498/06

    CPC分类号： C07D498/06

    摘要： This invention relates to a process for obtaining levofloxacin free from salts. In this process the starting product used is the compound (V), alkaline hydrolysis of which within a water-(C1-C4)alcohol mixture, and subsequent neutralisation and separation of the salts, leads to levofloxacin free from salts, without need to carry out any final step of extraction and without using halogenated solvents.One characteristic of the process described is that no extractions are necessary in the final step of the process.

    摘要翻译： 本发明涉及获得不含盐的左氧氟沙星的方法。 在该方法中，使用的起始产物是水（C 1 -C 4）醇混合物中碱性水解的化合物（V），随后盐的中和和分离，导致左氧氟沙星不含盐，而不需要携带 任何最后一步的提取和不使用卤化溶剂。 所描述的过程的一个特征是在该过程的最后步骤中不需要提取。