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公开(公告)号：US09173935B2
公开(公告)日：2015-11-03
申请号：US13097838
申请日：2011-04-29
申请人： Roberto Maj , Franco Pattarino , Emanuela Mura , Alcide Barberis
发明人： Roberto Maj , Franco Pattarino , Emanuela Mura , Alcide Barberis
IPC分类号： A61K39/39 , A61K31/522 , A61K31/685 , A61K39/015 , A61K39/04 , A61K47/48 , A61K39/00 , C07F9/6561
CPC分类号： C07F9/65616 , A61K31/522 , A61K31/685 , A61K39/00 , A61K39/015 , A61K39/04 , A61K39/39 , A61K47/544 , A61K2039/55511 , Y02A50/386
摘要： Provided in some embodiments are compositions comprising a compound having a structure according to Formula A or Formula B: or a pharmaceutically acceptable salt, tautomer or hydrate thereof, where X2 is a bond or linker, X3 is bond or —PO4—, and X1, R1, R2, R3, and n are described herein. Also provided in some embodiments are methods for making and using such compounds and compositions.
摘要翻译： 在一些实施方案中提供了包含具有式A或式B结构的化合物或其药学上可接受的盐，互变异构体或水合物的组合物，其中X 2为键或连接基，X 3为键或-PO 4 - ，且X 1， R1，R2，R3和n在本文中描述。 在一些实施方案中还提供了制备和使用这些化合物和组合物的方法。
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公开(公告)号：US20120003298A1
公开(公告)日：2012-01-05
申请号：US13097850
申请日：2011-04-29
申请人： Alcide Barberis , Franco Pattarino , Emanuela Mura , Roberto Maj
发明人： Alcide Barberis , Franco Pattarino , Emanuela Mura , Roberto Maj
CPC分类号： A61K47/544
摘要： Provided in some embodiments are methods for inducing an antigen-specific immune response in a subject, comprising administering a compound having a structure according to Formula A or Formula B: or a pharmaceutically acceptable salt, tautomer or hydrate thereof, where X2 is a bond or linker, X3 is —PO4—, and X1, R1, R2, R3, and n are described herein. Also provided in some embodiments are methods for making and using such compounds and compositions.
摘要翻译： 在一些实施方案中提供了在受试者中诱导抗原特异性免疫应答的方法，包括施用具有式A或式B结构的化合物：或其药学上可接受的盐，互变异构体或水合物，其中X 2是一个或多个 接头，X3是-PO4-，并且X1，R1，R2，R3和n在本文中描述。 在一些实施方案中还提供了制备和使用这些化合物和组合物的方法。
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公开(公告)号：US09066940B2
公开(公告)日：2015-06-30
申请号：US13147194
申请日：2010-02-05
申请人： Lorenzo Leoni , Roberto Maj , Franco Pattarino , Carlo Vecchio
发明人： Lorenzo Leoni , Roberto Maj , Franco Pattarino , Carlo Vecchio
IPC分类号： A61K31/4164 , A61K31/437 , A61K47/40 , A61K47/10 , A61K31/4745 , A61K9/00 , A61K47/12 , A61K47/34
CPC分类号： A61K47/40 , A61K9/0014 , A61K9/0034 , A61K31/4745 , A61K47/10 , A61K47/12 , A61K47/34
摘要： The present invention relates in general to the field of modulators of the innate immune system, particularly to pharmaceutical compositions comprising imidazoquinolin(amines) and derivatives thereof, preferably suitable for local administration, such as, intravesical administration. In addition, the present invention concerns the use of imidazoquinolin(amines) and derivatives thereof for intravesical treatment of bladder diseases, such as, for example, bladder cancer and cystitis. The present invention furthermore comprises methods of treatment for these diseases as well as methods of administration of the inventive pharmaceutical compositions.
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4.发明申请PHARMACEUTICAL COMPOSITIONS COMPRISING IMIDAZOQUINOLIN(AMINES) AND DERIVATIVES THEREOF SUITABLE FOR LOCAL ADMINISTRATION 有权包含咪达喹啉（AMINES）的药物组合物及其适用于当地管理的衍生物公开(公告)号：US20110319442A1
公开(公告)日：2011-12-29
申请号：US13147194
申请日：2010-02-05
申请人： Lorenzo Leoni , Roberto Maj , Franco Pattarino , Carlo Vecchio
发明人： Lorenzo Leoni , Roberto Maj , Franco Pattarino , Carlo Vecchio
IPC分类号： A61K31/437 , A61P13/10 , A61P35/00 , A61P17/00 , A61P17/12
CPC分类号： A61K47/40 , A61K9/0014 , A61K9/0034 , A61K31/4745 , A61K47/10 , A61K47/12 , A61K47/34
摘要： The present invention relates in general to the field of modulators of the innate immune system, particularly to pharmaceutical compositions comprising imidazoquinolin(amines) and derivatives thereof, preferably suitable for local administration, such as, intravesical administration. In addition, the present invention concerns the use of imidazoquinolin(amines) and derivatives thereof for intravesical treatment of bladder diseases, such as, for example, bladder cancer and cystitis. The present invention furthermore comprises methods of treatment for these diseases as well as methods of administration of the inventive pharmaceutical compositions.
摘要翻译： 本发明一般涉及先天免疫系统的调节剂领域，特别涉及包含咪唑并喹啉（胺）及其衍生物的药物组合物，优选适用于局部给药，例如膀胱内给药。 此外，本发明涉及咪唑并喹啉（胺）及其衍生物用于膀胱疾病例如膀胱癌和膀胱炎的膀胱内治疗。 本发明还包括治疗这些疾病的方法以及施用本发明的药物组合物的方法。
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公开(公告)号：US20120009247A1
公开(公告)日：2012-01-12
申请号：US13097838
申请日：2011-04-29
申请人： Roberto Maj , Franco Pattarino , Emanuela Mura , Alcide Barberis
发明人： Roberto Maj , Franco Pattarino , Emanuela Mura , Alcide Barberis
CPC分类号： C07F9/65616 , A61K31/522 , A61K31/685 , A61K39/00 , A61K39/015 , A61K39/04 , A61K39/39 , A61K47/544 , A61K2039/55511 , Y02A50/386
摘要： Provided in some embodiments are compositions comprising a compound having a structure according to Formula A or Formula B: or a pharmaceutically acceptable salt, tautomer or hydrate thereof, where X2 is a bond or linker, X3 is bond or —PO4—, and X1, R1, R2, R3, and n are described herein. Also provided in some embodiments are methods for making and using such compounds and compositions.
摘要翻译： 在一些实施方案中提供了包含具有式A或式B结构的化合物或其药学上可接受的盐，互变异构体或水合物的组合物，其中X 2为键或连接基，X 3为键或-PO 4 - ，且X 1， R1，R2，R3和n在本文中描述。 在一些实施方案中还提供了制备和使用这些化合物和组合物的方法。
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