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公开(公告)号：US5126140A
公开(公告)日：1992-06-30
申请号：US382411
申请日：1989-07-24
申请人： Ralph K. Ito , Frank W. LoGerfo
发明人： Ralph K. Ito , Frank W. LoGerfo
CPC分类号： A61L33/0047 , A61L33/0029
摘要： Disclosed is a biocompatible, thromboresistant substance useful for implantable and extracorporeal devices in contact with the vascular system, and methods for producing the same. The biocompatible, thromboresistant substance comprises a synthetic, biocompatible material, at least one biocompatible base coat layer adhered to at least one surface of the material, and the thrombogenesis inhibitor thrombomodulin immobilized on the base coat layer via a component capable of binding the inhibitor without affecting its thrombogenesis-inhibiting activity.
摘要翻译： 公开了可用于与血管系统接触的可植入和体外装置的生物相容性抗血栓物质及其制备方法。 生物相容的抗血栓物质包括合成的生物相容性材料，至少一种生物相容的底涂层粘附在该材料的至少一个表面上，并且血栓形成抑制剂血栓调节蛋白通过能够结合抑制剂的成分固定在底涂层上而不影响 其血栓形成抑制活性。
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公开(公告)号：US5281662A
公开(公告)日：1994-01-25
申请号：US719031
申请日：1991-06-21
申请人： Ralph K. Ito , Frank W. LoGerfo
发明人： Ralph K. Ito , Frank W. LoGerfo
CPC分类号： A61K47/48276 , A61K47/48284 , A61L27/54 , A61L33/0011 , A61L33/0029 , A61L33/0047 , D06M16/00 , D06P3/26 , D06P3/54 , A61L2300/104 , A61L2300/252 , A61L2300/406 , A61L2300/442
摘要： Disclosed is a treated material including a base material such as an extrudate, a woven fabric, or unwoven fibers, a disperse dye-type molecule such as a dye or antibiotic dispersed within and non-covalently adhered to the base material, and a molecule-of-interest immobilized on the base material by way of a reactive group on the disperse dye-type molecule. Also disclosed are methods of producing the treated material.
摘要翻译： 公开了一种处理材料，其包括基材，例如挤出物，机织织物或非织造纤维，分散染料型分子如染料或抗生素分散在非共价附着于基材上，分子 - 通过在分散染料型分子上的反应性基团固定在基材上。 还公开了生产经处理的材料的方法。
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公开(公告)号：US5167960A
公开(公告)日：1992-12-01
申请号：US227700
申请日：1988-08-03
申请人： Ralph K. Ito , Frank W. LoGerfo
发明人： Ralph K. Ito , Frank W. LoGerfo
CPC分类号： A61L33/128 , A61L33/0029
摘要： Disclosed is a biocompatible, thromboresistant substance useful for implantable and extracorpeoreal devices in contact with the vascular system, and methods for producing the same. The biocompatible, thromboresistant substance comprises a synthetic, biocompatible material, at least one biocompatible base coat layer adhered to at least one surface of the material, and a thrombogenesis inhibitor immobilized on the base coat layer via a component capable of binding the inhibitor. The thrombogenesis inhibitor is hirudin, or an active analog or fragment thereof.
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公开(公告)号：US08119400B2
公开(公告)日：2012-02-21
申请号：US11890318
申请日：2007-08-03
CPC分类号： C12N15/113 , C12N2310/14
摘要： In particular embodiments, the present invention provides methods of inhibiting smooth muscle cell responses and methods of treating or preventing vascular proliferative disease caused by smooth muscle cell migration and proliferation. More specifically, smooth muscle cell responses are inhibited by introducing an agent into smooth muscle cells, wherein the agent inhibits an activity of one or more members of the myristoylated alanine-rich C kinase substrate (MARCKS) family of proteins. The invention also provides methods of inhibiting expression of one or more genes encoding a member of the MARCKS family of proteins in a cell.
摘要翻译： 在具体实施方案中，本发明提供抑制平滑肌细胞反应的方法以及治疗或预防由平滑肌细胞迁移和增殖引起的血管增生性疾病的方法。 更具体地，通过将平滑肌细胞引入试剂来抑制平滑肌细胞应答，其中所述试剂抑制富含多糖的富含丙氨酸的富含丙氨酸的激酶底物（MARCKS）蛋白质的一个或多个成员的活性。 本发明还提供抑制细胞中编码MARCKS蛋白家族成员的一种或多种基因表达的方法。
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公开(公告)号：US07037527B2
公开(公告)日：2006-05-02
申请号：US10352286
申请日：2003-01-27
IPC分类号： A61K31/765 , A61F13/00 , C08L67/02
CPC分类号： C08G63/916
摘要： The invention features a method of treating polyester material to generate functional carboxylic acid and amine groups. These functional groups can be used as sites for covalent bond formation to attach chemical or biological moieties. This bifunctionalized polyester polymer can be used in any medical application in which biocompatible polymers are used.
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6.发明授权Method for making infection-resistant fabricated textile articles for biomedical applications 失效制造抗感染制造纺织制品用于生物医学应用的方法公开(公告)号：US06592885B2
公开(公告)日：2003-07-15
申请号：US09876604
申请日：2001-06-07
IPC分类号： A01N2534
CPC分类号： A61F13/00995 , A61F2013/0091 , A61K9/7007 , A61K31/496 , A61L27/507 , A61L27/54 , A61L2300/404 , A61L2300/406 , Y10T442/2525
摘要： The present invention provides a method for making an infection-resistant fabricated textile article which is suitable for any in-vivo usage either as a topical bandage, on an implantable configured construct, or as part of a prosthetic mechanical appliance. The method of manufacture applies broadly to any and all fabrics, cloths, gauzes, and/or films comprised in whole or in part of fibers; and provides an infection-resistant textile of valued use in a wide range and variety of medical applications.
摘要翻译： 本发明提供一种用于制造感染抗性的制造纺织制品的方法，其适用于作为局部绷带，植入式构造构造物或作为假体机械器具的一部分的任何体内使用。 制造方法广泛地适用于全部或部分纤维中的任何和所有织物，布，纱布和/或薄膜; 并提供广泛和各种医疗应用中有价值用途的耐感染纺织品。
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公开(公告)号：US5019393A
公开(公告)日：1991-05-28
申请号：US227728
申请日：1988-08-03
申请人： Ralph K. Ito , Frank W. LoGerfo
发明人： Ralph K. Ito , Frank W. LoGerfo
IPC分类号： A61L33/00
CPC分类号： A61L33/0047 , A61L33/0029
摘要： Disclosed is a biocompatible, thromboresistant substance useful for implantable and extracorporeal devices in contact with the vascular system, and methods for producing the same. The biocompatible, thromboresistant substance comprises a synthetic, biocompatible material, at least one biocompatible base coat layer adhered to at least one surface of the material, and a thrombogenesis inhibitor immobilized on the base coat layer via a component capable of binding the inhibitor. The thrombogenesis inhibitor is streptokinase, urokinase, tissue plasminogen activator, ATPase, 5'-nucleotidase, and active fragments and active analogs thereof.
摘要翻译： 公开了可用于与血管系统接触的可植入和体外装置的生物相容性抗血栓物质及其制备方法。 生物相容的抗血栓物质包括合成的生物相容性材料，至少一种粘附于该材料的至少一个表面的生物相容性底涂层，以及通过能够结合抑制剂的成分固定在底涂层上的血栓形成抑制剂。 血栓形成抑制剂是链激酶，尿激酶，组织纤溶酶原激活物，ATP酶，5'-核苷酸酶及其活性片段及其活性类似物。
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公开(公告)号：US20080299654A1
公开(公告)日：2008-12-04
申请号：US11890318
申请日：2007-08-03
CPC分类号： C12N15/113 , C12N2310/14
摘要： In particular embodiments, the present invention provides methods of inhibiting smooth muscle cell responses and methods of treating or preventing vascular proliferative disease caused by smooth muscle cell migration and proliferation. More specifically, smooth muscle cell responses are inhibited by introducing an agent into smooth muscle cells, wherein the agent inhibits an activity of one or more members of the myristoylated alanine-rich C kinase substrate (MARCKS) family of proteins. The invention also provides methods of inhibiting expression of one or more genes encoding a member of the MARCKS family of proteins in a cell.
摘要翻译： 在具体实施方案中，本发明提供抑制平滑肌细胞反应的方法以及治疗或预防由平滑肌细胞迁移和增殖引起的血管增生性疾病的方法。 更具体地，通过将平滑肌细胞引入试剂来抑制平滑肌细胞应答，其中所述试剂抑制富含多糖的富含丙氨酸的富含丙氨酸的激酶底物（MARCKS）蛋白质的一个或多个成员的活性。 本发明还提供抑制细胞中编码MARCKS蛋白家族成员的一种或多种基因表达的方法。
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9.发明授权公开(公告)号：US06743253B2
公开(公告)日：2004-06-01
申请号：US09796569
申请日：2001-02-28
IPC分类号： A61F206
CPC分类号： C08G18/44 , A61L27/34 , A61L27/40 , A61L27/507 , C08G18/0823 , C08G18/10 , C08L23/06 , C08L23/12 , C08L67/02 , C08L75/04 , C08L77/00 , C08L83/04 , A61L27/54 , C08G18/34
摘要： Provided is a biocompatible device which has been coated or sealed with a polyether or polyether/carbonate based urethane polymer that contains functional groups (e.g. carboxylic acid groups) which are capable of serving as anchor sites for protein binding.
摘要翻译： 提供了一种生物相容性装置，其已经用能够用作蛋白质结合的锚定位点的官能团（例如羧酸基团）的聚醚或聚醚/碳酸酯基氨基甲酸酯聚合物涂覆或密封。
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公开(公告)号：US5112615A
公开(公告)日：1992-05-12
申请号：US592554
申请日：1990-10-04
申请人： Ralph K. Ito , Frank W. LoGerfo
发明人： Ralph K. Ito , Frank W. LoGerfo
CPC分类号： A61L33/0029 , A61K38/58 , A61K47/48276 , A61L33/128 , Y10S530/81 , Y10S530/812 , Y10S530/813
摘要： Disclosed is a soluble, biocompatible, pharmacological agent for inhibiting thrombin generation and thrombus formation, and methods for producing the same. The pharmacological agent or conjugate includes a soluble, biocompatible carrier and a thrombogenesis inhibitor immobilized thereto via the carrier which binds the inhibitor. The thrombogenesis inhibitor is hirudin, or an active analog or active fragment thereof. The thrombogenesis inhibitor may be bound to the carrier via a bifunctional cross-linking reagent.
摘要翻译： 公开了用于抑制凝血酶产生和血栓形成的可溶性，生物相容性药理学试剂及其制备方法。 药理学试剂或缀合物包括通过结合抑制剂的载体固定在其上的可溶性生物相容性载体和血栓发生抑制剂。 血栓形成抑制剂是水蛭素或其活性的类似物或活性片段。 血栓形成抑制剂可以通过双功能交联剂与载体结合。
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