利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

7 条记录 (耗时 0.023 秒)

    Drug dispensing wound dressing
    4.
    发明授权
    Drug dispensing wound dressing 失效
    药物分配伤口敷料

    公开(公告)号：US4614787A

    公开(公告)日：1986-09-30

    申请号：US670810

    申请日：1984-11-13

    申请人： Michael Szycher ,  Donald J. Dempsey ,  Jonathan L. Rolfe

    发明人： Michael Szycher ,  Donald J. Dempsey ,  Jonathan L. Rolfe

    IPC分类号： A61F13/15 ,  A61L15/26 ,  A61L15/44 ,  C08G18/10 ,  A61F13/00

    CPC分类号： A61L15/44 ,  A61L15/26 ,  A61F2013/530007 ,  A61L2300/402 ,  A61L2300/404 ,  A61L2300/41 ,  A61L2300/418

    摘要： The disclosed wound dressings have a drug dispersed throughout a polyurethane matrix that is the reaction product of: (A) An isocyante terminated prepolymer formed by reaction of isophorone diisocyanate and a macroglycol and (B) a monomer containing hydroxyl and vinyl groups. The reaction product is a vinyl terminated polyurethane oligomer which is liquid at room temperature and which may be readily admixed with a pharmacoactive substance and a photosensitizer, formed into a film and cured by exposure to UV light without release of heat.In the most preferred embodiments the foregoing oligomer is codissolved in an organic solvent with a polyurethane polymer which is the reaction product of:dicyclohexyl methane diisocyanate;a polytetramethylene ether polyol having a molecular weight in the range of 1000-3000 daltons; and1,4-butane diol.That solution is then admixed with the pharmacoactive agent, formed into a film and cured.

    摘要翻译： 所公开的伤口敷料具有分散在整个聚氨酯基质中的药物，其是以下物质的反应产物：（A）通过异佛尔酮二异氰酸酯和大分子二醇反应形成的异氰酸酯封端的预聚物和（B）含有羟基和乙烯基的单体。 反应产物是在室温下为液体的乙烯基封端的聚氨酯低聚物，其可以容易地与药物活性物质和光敏剂混合，形成膜并通过暴露于UV光而不释放热而固化。 在最优选的实施方案中，上述低聚物与聚氨酯聚合物共同存在于有机溶剂中，所述聚氨酯聚合物是以下物质的反应产物：二环己基甲烷二异氰酸酯; 分子量为1000-3000道尔顿的聚四亚甲基醚多元醇; 和1,4-丁二醇。 然后将该溶液与药物活性剂混合，形成膜并固化。

    Drug release system
    6.
    发明授权
    Drug release system 失效
    药物释放系统

    公开(公告)号：US4638043A

    公开(公告)日：1987-01-20

    申请号：US768623

    申请日：1985-08-23

    申请人： Michael Szycher ,  Donald J. Dempsey ,  Jonathan L. Rolfe

    发明人： Michael Szycher ,  Donald J. Dempsey ,  Jonathan L. Rolfe

    IPC分类号： A61M37/00 ,  A61F13/15 ,  A61K9/22 ,  A61K9/70 ,  A61L15/26 ,  A61L15/44 ,  C08G18/44 ,  C08G18/67 ,  C08G18/10 ,  A61F13/00

    CPC分类号： A61K9/7084 ,  A61L15/26 ,  A61L15/44 ,  C08G18/44 ,  C08G18/672 ,  A61F2013/530007 ,  A61K9/703 ,  A61L2300/608

    摘要： A drug releasing system in the form of a medical patch comprised of a drug dispensing polyurethane member as a matrix for a therapeutically effective amount of drug dispersed therein. The polyurethane of the drug dispensing or releasing member is a polyurethane acrylic copolymer which is the reaction product of an oligomer of a diisocyanate, a glycol with a molecular weight between the range of 500-5,000 molecular weight units and an acrylyl chain terminator having a molecular weight between the range of 40-200 molecular weight units cured by actinic radiation. In its preferred embodiment, the foregoing drug releasing or dispensing member is incorporated into a medical patch or drug release system comprised of successive layers of an ultrathin polyurethane substrate, pressure sensitive adhesive, the above-described drug releasing member and optionally a second layer of adhesive.The drug release system of the present invention is biocompatible, oxygen and water vapor permeable, flexible and can incorporate a wide variety of drugs for a controlled, sustained release to the wearer.

    摘要翻译： 医药贴剂形式的药物释放系统，其由作为基质的药物分配聚氨酯部件组成，用于分散在其中的治疗有效量的药物。 药物分配或释放构件的聚氨酯是聚氨酯丙烯酸共聚物，其是二异氰酸酯的低聚物，分子量在500-5,000分子量单元范围内的二醇与具有分子量的丙烯酰链终止剂之间的反应产物 通过光化辐射固化的40-200分子量单位的范围之间的重量。 在其优选的实施方案中，将上述药物释放或分配构件并入由超薄聚氨酯基材，压敏粘合剂，上述药物释放组件和任选的第二层粘合剂的连续层组成的医疗补片或药物释放系统中 。 本发明的药物释放系统是生物相容性的，氧气和水蒸气可透过的，柔性的，并且可以掺入多种用于对受试者持续释放的药物。