-
1.发明申请NOVEL CHIRAL SELECTORS AND STATIONARY PHASES FOR SEPARATING ENANTIOMER MIXTURES 有权新型手持式选择器和分离器的混合气相分离器公开(公告)号：US20090229352A1
公开(公告)日：2009-09-17
申请号：US12400846
申请日：2009-03-10
IPC分类号： G01N30/02 , C07C229/02 , C07C229/34
CPC分类号： B01J20/29 , B01D15/3833 , B01J20/286 , C07B57/00 , C07B2200/07 , C07B2200/11 , C07C51/487 , C07C227/34 , C07C231/20 , C07C233/87 , C07C237/22 , C07C253/34 , C07C269/08 , C07C59/54 , C07C229/34 , C07C229/36 , C07C233/47 , C07C255/58 , C07C271/22
摘要： Chiral selectors having α-unsubstituted β-amino acid derivatives of the structure: a stationary phase for separating substance mixtures containing the chiral selector, and processes for separating mixtures of chiral substances, including enantiomers, and especially enantiomers of substances selected from β-amino acids and derivatives thereof, α-amino acids and α-hydroxy acids are provided.
摘要翻译： 具有α-取代的β-氨基酸衍生物的手性选择剂：用于分离含有手性选择剂的物质混合物的固定相，以及用于分离手性物质的混合物的方法，包括对映异构体，特别是选自β-氨基酸的物质的对映异构体 并提供其衍生物，α-氨基酸和α-羟基酸。
-
2.发明授权公开(公告)号：US08647882B2
公开(公告)日：2014-02-11
申请号：US13241767
申请日：2011-09-23
IPC分类号： G01N30/02 , C07C205/00
CPC分类号： B01J20/29 , B01D15/3833 , B01J20/286 , C07B57/00 , C07B2200/07 , C07B2200/11 , C07C51/487 , C07C227/34 , C07C231/20 , C07C233/87 , C07C237/22 , C07C253/34 , C07C269/08 , C07C59/54 , C07C229/34 , C07C229/36 , C07C233/47 , C07C255/58 , C07C271/22
摘要： Chiral selectors having α-unsubstituted β-amino acid derivatives of the structure: a stationary phase for separating substance mixtures containing the chiral selector, and processes for separating mixtures of chiral substances, including enantiomers, and especially enantiomers of substances selected from β-amino acids and derivatives thereof, α-amino acids and α-hydroxy acids are provided.
摘要翻译： 具有α-取代的β-氨基酸衍生物的手性选择剂：用于分离含有手性选择剂的物质混合物的固定相，以及用于分离手性物质的混合物的方法，包括对映异构体，特别是选自β-氨基酸的物质的对映异构体 并提供其衍生物，α-氨基酸和α-羟基酸。
-
3.发明申请NOVEL CHIRAL SELECTORS AND STATIONARY PHASES FOR SEPARATING ENANTIOMER MIXTURES 有权新型手持式选择器和分离器的混合气相分离器公开(公告)号：US20120015443A1
公开(公告)日：2012-01-19
申请号：US13241767
申请日：2011-09-23
IPC分类号： G01N30/02 , C07C229/34 , G01N30/00 , C07F7/10
CPC分类号： B01J20/29 , B01D15/3833 , B01J20/286 , C07B57/00 , C07B2200/07 , C07B2200/11 , C07C51/487 , C07C227/34 , C07C231/20 , C07C233/87 , C07C237/22 , C07C253/34 , C07C269/08 , C07C59/54 , C07C229/34 , C07C229/36 , C07C233/47 , C07C255/58 , C07C271/22
摘要： Chiral selectors having α-unsubstituted β-amino acid derivatives of the structure: a stationary phase for separating substance mixtures containing the chiral selector, and processes for separating mixtures of chiral substances, including enantiomers, and especially enantiomers of substances selected from β-amino acids and derivatives thereof, α-amino acids and α-hydroxy acids are provided.
摘要翻译： 具有α-未取代的结构式的手性选择剂：用于分离含有手性选择剂的物质混合物的固定相和用于分离手性物质的混合物的方法，包括对映体，特别是选自以下物质的对映异构体： 提供氨基酸及其衍生物，α-氨基酸和α-羟基酸。
-
公开(公告)号：US20110152506A1
公开(公告)日：2011-06-23
申请号：US12996203
申请日：2009-05-28
申请人： Wolfgang Wienand , Franz-Rudolf Kunz , Dietmar Reichert , Wilfried Eul , Rudolf Hanko , Christian Birr , Monika Singhofer-Wowra , Dagmar Schopohl-König , Lars Faber
发明人： Wolfgang Wienand , Franz-Rudolf Kunz , Dietmar Reichert , Wilfried Eul , Rudolf Hanko , Christian Birr , Monika Singhofer-Wowra , Dagmar Schopohl-König , Lars Faber
IPC分类号： C07K14/505
CPC分类号： C07K14/505
摘要： The present invention relates to a method for preparing erythropoietin, wherein culture supernatant of erythropoietin-producing eukaryotic cells containing erythropoietin are subjected to the following steps: a) Removing the cell components; and b) treating the product from a) to the following chromatography steps in the sequence indicated i) reversed phase chromatography; ii) anion exchange chromatography; iii) hydroxyapatite chromatography.
摘要翻译： 本发明涉及一种制备促红细胞生成素的方法，其中含促红细胞生成素生产的含促红细胞生成素的真核细胞的培养物上清液经受以下步骤：a）除去细胞成分; 和b）按照所示的顺序将产物从a）处理到以下色谱步骤：i）反相色谱; ii）阴离子交换层析; iii）羟基磷灰石层析。
-
5.发明授权公开(公告)号：US08268631B2
公开(公告)日：2012-09-18
申请号：US12400846
申请日：2009-03-10
IPC分类号： G01N30/02
CPC分类号： B01J20/29 , B01D15/3833 , B01J20/286 , C07B57/00 , C07B2200/07 , C07B2200/11 , C07C51/487 , C07C227/34 , C07C231/20 , C07C233/87 , C07C237/22 , C07C253/34 , C07C269/08 , C07C59/54 , C07C229/34 , C07C229/36 , C07C233/47 , C07C255/58 , C07C271/22
摘要： Chiral selectors having α-unsubstituted β-amino acid derivatives of the structure: a stationary phase for separating substance mixtures containing the chiral selector, and processes for separating mixtures of chiral substances, including enantiomers, and especially enantiomers of substances selected from β-amino acids and derivatives thereof, α-amino acids and α-hydroxy acids are provided.
摘要翻译： 具有α-未取代的结构式的手性选择剂：用于分离含有手性选择剂的物质混合物的固定相和用于分离手性物质的混合物的方法，包括对映体，特别是选自以下物质的对映异构体： 提供氨基酸及其衍生物，α-氨基酸和α-羟基酸。
-
公开(公告)号：US20120021441A1
公开(公告)日：2012-01-26
申请号：US13140190
申请日：2009-12-07
申请人： Franz-Rudolf Kunz , Florian Glaser , Wolfgang Wienand , Rudolf Hanko , Wilfried Eul , Dietmar Reichert
发明人： Franz-Rudolf Kunz , Florian Glaser , Wolfgang Wienand , Rudolf Hanko , Wilfried Eul , Dietmar Reichert
CPC分类号： G01N33/746
摘要： The invention relates to a method for determining the isoform composition of erythropoietin, comprising the following steps: a) isoelectrical focusing of a sample comprising erythropoietin in a gel over a pH range having a lower limit of 2.5 to 3.5 and an upper limit of 5 to 8, wherein the sample comprising erythropoietin originates from a culture supernatant of erythropoietin producing eukaryotic cells; b) transferring of the proteins comprised and separated in the gel to a membrane; c) verifying the erythropoietin bound to the membrane by specific antibodies; and to a method for in-process control of culture supernatants of erythropoietin producing eukaryotic cells during the fermentative production process.
摘要翻译： 本发明涉及一种测定红细胞生成素的同种型组成的方法，包括以下步骤：a）将包含促红细胞生成素的样品在凝胶中的等电聚焦在pH范围内，其下限为2.5至3.5，上限为5至 8，其中包含促红细胞生成素的样品源自产生促红细胞生成素的真核细胞的培养上清液; b）将在凝胶中包含和分离的蛋白质转移到膜上; c）通过特异性抗体验证与该膜结合的促红细胞生成素; 以及在发酵生产过程中用于在产生促红细胞生成素的真核细胞的培养物上清液中进行过程控制的方法。
-
公开(公告)号：US20110189732A1
公开(公告)日：2011-08-04
申请号：US12996070
申请日：2009-06-03
申请人： Wolfgang Wienand , Franz-Rudolf Kunz , Dietmar Reichert , Wilfried Eul , Rudolf Hanko , Christian Birr , Monika Singhofer-Wowra , Dagmar Schopohl-König , Lars Faber
发明人： Wolfgang Wienand , Franz-Rudolf Kunz , Dietmar Reichert , Wilfried Eul , Rudolf Hanko , Christian Birr , Monika Singhofer-Wowra , Dagmar Schopohl-König , Lars Faber
IPC分类号： C12P21/00
CPC分类号： C12P21/005 , C07K14/505
摘要： The present invention relates to a process for the fermentative continuous production of erythropoietin, where eukaryotic erythropoietin-producing cells are cultured in a perfusion reactor while retaining the cells, the glucose concentration in the culture supernatant being adjusted via the perfusion rate and the cell number via the cell retention rate and/or the outward transferal of defined amounts of cell-containing culture medium from the bioreactor within preset zones.
摘要翻译： 本发明涉及发酵连续生产促红细胞生成素的方法，其中将真核促红细胞生成素生成细胞在灌注反应器中培养，同时保留细胞，培养上清液中的葡萄糖浓度通过灌注速率和细胞数量经由 细胞保留率和/或从预定区域内的来自生物反应器的限定量的含细胞培养基向外转移。
-
公开(公告)号：US06258933B1
公开(公告)日：2001-07-10
申请号：US09276709
申请日：1999-03-26
IPC分类号： C07K116
摘要： The present invention relates to a process for the one-stage resalting and purification of oligopeptides. Oligopeptides are often not formed directly as acetates when synthesised. Acetate salts of oligopeptides are however desirable as bulk-active material for medical and formulation reasons. Processes known from the prior art have hitherto involved two separate steps or pyridine-containing solvents. The resalting and purification can be combined in one step and the use of pyridine as solvent can be avoided, if the oligopeptide in the form of its chloride salt is purified with an acetate-containing solvent by liquid chromatography methods.
摘要翻译： 本发明涉及寡肽一步骤分离和纯化的方法。 当合成时，寡肽通常不直接形成为乙酸酯。 然而，寡肽的乙酸盐作为用于医学和制剂原因的体积活性材料是理想的。 已知现有技术的方法迄今涉及两个独立的步骤或含吡啶的溶剂。 如果用含有乙酸酯的溶剂通过液相色谱法纯化其氯化物盐形式的寡肽，则可以将脱盐和纯化结合在一个步骤中，并且可以避免使用吡啶作为溶剂。
-
公开(公告)号：US6060571A
公开(公告)日：2000-05-09
申请号：US804698
申请日：1997-02-21
CPC分类号： C08G2/14 , C08G2/18 , C08G4/00 , C08G6/00 , Y10S526/909
摘要： Acrolein polymer from acrolein and one or more polyhydric alcohols, characterized by release of monomeric acrolein in aqueous systems and hence by a prolonged effect on microorganisms, is prepared by adding acrolein to a reaction medium containing catalyst in dissolved form, and not allowing the temperature of the reaction medium to rise about 50.degree. C. The acrolein polymer may be used in aqueous systems as a biocide.
摘要翻译： 丙烯醛和一种或多种多元醇的丙烯醛聚合物，其特征在于在水性体系中释放单体丙烯醛，并因此通过延长对微生物的作用，通过将丙烯醛加入到含有溶解形式的催化剂的反应介质中，并且不允许 反应介质升高约50℃。丙烯醛聚合物可用作水系统中的杀生物剂。
-
-
-
-
-
-
-
-
搜索结果
9 条记录 (耗时 0.016 秒)
