Abstract:
A tubulysin compound conjugate is provided herein. The conjugate comprises a protein based recognition-molecule (PBRM) and a polymeric carrier substituted with one or more -LD-D, the protein based recognition-molecule being connected to the polymeric carrier by LP. Each occurrence of D is independently a tubulysin compound having a molecular weight ≤5 kDa. LD and LP are distinct linkers connecting the tubulysin compound and PBRM to the polymeric carrier respectively. Also disclosed are polymeric scaffolds useful for conjugating with a PBRM to form a polymer-tubulysin compound-PBRM conjugate described herein, compositions comprising the conjugates, methods of their preparation, and methods of treating various disorders with the conjugates or their compositions.
Abstract:
An aqueous adhesive composition comprises a phenol/aldehyde resin and less than 16% by weight of unsaturated diene elastomer latex. The phenol/aldehyde resin is based on an aromatic polyaldehyde bearing at least two aldehyde functional groups and comprising at least one aromatic nucleus, and on a polyphenol comprising one or more aromatic nuclei. If just one aromatic nucleus is present, the latter bears two or three hydroxyl functional groups in the meta position with respect to one another and the remainder of the aromatic nucleus is unsubstituted. If several aromatic nuclei are present, at least two of them each bear two or three hydroxyl functional groups in the meta position with respect to one another, it being understood that the two positions ortho to at least one of these hydroxyl functional groups are unsubstituted.
Abstract:
The present invention provides a method for producing a polydioxolane, which includes polymerizing a 1,3-dioxolane compound represented by the formula (1) in the presence of a cationic catalyst and a sterically hindered phenol in an amount of 10 to 1,500 ppm, based on the 1,3-dioxolane compound. In the formula (1), R1 to R6 are the same or difference and each independently represents a hydrogen atom, an alkyl group, an aryl group, a hydroxyalkyl group, an alkyloxy group, or an aryloxy group.
Abstract:
There is provided an aromatic hydrocarbon formaldehyde resin obtained by reacting an aromatic hydrocarbon compound (A) represented by the following formula (1) with formaldehyde (B) in the presence of an acidic catalyst. wherein R represents an organic group having 1 to 10 carbon atoms; l represents an integer of 0 to 2, and m and n represent integers satisfying 1≦m+n≦10, m≧0 and n≧1.
Abstract translation:提供通过在酸性催化剂的存在下使由下式(1)表示的芳族烃化合物(A)与甲醛(B)反应得到的芳族烃甲醛树脂。 其中R表示具有1-10个碳原子的有机基团; l表示0〜2的整数,m和n表示满足1&nlE的整数; m + n≦̸ 10,m≥0,n≥1。
Abstract:
The patent application relates to a process for preparing polyoxymethylene by polymerization of a reaction mixture (RG) which comprises at least one formaldehyde source and at least one initiator mixture (IG), wherein the initiator mixture (IG) comprises at least one polymerization initiator and at least one solvent of the general formula (I) R1—O—[—R3—O—]m—R2 (I), where m is 1, 2, 3 or 4; R1 and R2 are each, independently of one another, C3-C6-alkyl; R3 is C1-C5-alkylene.
Abstract translation:该专利申请涉及通过聚合包含至少一种甲醛源和至少一种引发剂混合物(IG)的反应混合物(RG)来制备聚甲醛的方法,其中引发剂混合物(IG)包含至少一种聚合引发剂和 至少一种通式(I)R 1 -O - [ - R 3 -O-] m -R 2(I)的溶剂,其中m为1,2,3或4; R 1和R 2各自独立地为C 3 -C 6 - 烷基; R3是C1-C5-亚烷基。
Abstract:
A method for molding amorphous polyether ether ketone including steps of preparing a molten mass including polyether ether ketone, cooling a mold assembly to a temperature of at most about 200° F., and injecting the molten mass into the cooled mold assembly.
Abstract:
Polyol compositions containing methane linkages derived from amino acids. The polyols are obtained from the reaction of the carbonate with the cadres in the amino acids. Individual amino acids or mixtures of amino acids that are prepared from the hydrolysis of the proteins can be used.
Abstract:
A copolymer includes (i) a plurality of ethylenic moieties A having a structure according to the following formula: wherein R2 and R3 independently represent hydrogen, a halogen, or an optionally substituted linear, branched, or cyclic alk(en)yl group, or an optionally substituted aromatic or heteroaromatic, and (ii) a plurality of acetal moieties B having a structure according to the following formula: wherein L represents a divalent linking group; x=0 or 1; and R1 represents an optionally substituted aromatic or heteroaromatic group including at least one hydroxyl group. Use of these polymers in the coating of lithographic printing plates provides a good abrasion resistance while the balance between the ink acceptance, arising from the ethylenic moieties, and the solubility in an alkaline developer, arising form the acetal moieties, can be controlled efficiently.
Abstract translation:共聚物包括(i)具有根据下式的结构的多个烯属部分A:其中R2和R3独立地表示氢,卤素或任选取代的直链,支链或环烷基(烯)基,或 任选取代的芳族或杂芳族,和(ii)具有根据下式的结构的多个缩醛部分B:其中L表示二价连接基团; x = 0或1; 并且R 1表示任选取代的包含至少一个羟基的芳族或杂芳族基团。 在平版印刷版的涂层中使用这些聚合物提供良好的耐磨性,而可以有效地控制从乙烯部分产生的油墨接受与由缩醛部分产生的在碱性显影剂中的溶解度之间的平衡。
Abstract:
In a method of forming a polyacetal or polyketal, a specific acetal- or ketal-containing bis(aryl)acetal is coupled with itself or a comonomer in the presence of a catalyst and a base. The polymerization reaction tolerates hydroxyl and other functional groups on the bis(aryl)acetal. Among other applications, the polyacetals and polyketals are useful components of photoresist compositions.