公开(公告)号：US20140011879A1

公开(公告)日：2014-01-09

申请号：US13825060

申请日：2011-09-27

Applicant: Frederic Baribaud ,  Bidisha Dasgupta

Inventor： Frederic Baribaud ,  Bidisha Dasgupta

IPC: G01N33/68 ,  G06F19/00

CPC classification number: G01N33/6893 ,  G01N2800/101 ,  G16H50/20

Abstract: Tools for diagnosis and management of patients suspected of having or having been previously diagnosed with systemic sclerosis are based on the determination one or more of the markers described herein, specifically, the markers having the amino acid sequence of SEQ ID NOS: 1-62 and 66-76 in a sample from the subject. Specific marker ratios and subsets of markers and ratios identify a patient and further subclassify the patient. The information may be used prospectively to study the response of subclassified patients to existing or novel therapeutic strategies.

Abstract translation: 怀疑患有或已经诊断为患有系统性硬化症的患者的诊断和管理的工具基于测定本文所述的一种或多种标记，具体地，具有SEQ ID NO：1-62的氨基酸序列的标记和 66-76来自受试者的样本。 特异性标记物比例和标记物比例识别患者并进一步对患者进行分类。 这些信息可以用于前瞻性研究分类患者对现有或新型治疗策略的反应。

公开(公告)号：US20110160085A1

公开(公告)日：2011-06-30

申请号：US13056741

申请日：2009-08-19

Applicant: Katherine Li ,  Frederic Baribaud

Inventor： Katherine Li ,  Frederic Baribaud

IPC: C40B30/04 ,  C40B99/00

CPC classification number: C12Q1/6883 ,  C12Q2600/106 ,  C12Q2600/118 ,  C12Q2600/158

Abstract: Methods and kits for the assessment of the suitability of and/or effectiveness of a target therapy for a TNF mediated-related disorder, such as ulcerative colitis, in a subject, which methods and kits evaluate the presence, absence, and/or magnitude of expression of two or more genes up or down regulated in association with anti-TNF responders in inflammatory gastrointestinal disorders, such as ulcerative colitis

Abstract translation: 用于评估受试者中TNF介导相关病症（例如溃疡性结肠炎）的目标疗法的适用性和/或有效性的方法和试剂盒，所述方法和试剂盒评估对象的存在，不存在和/或大小 在炎症性胃肠道疾病如溃疡性结肠炎中与抗TNF反应者相关联地上调或下调两种或更多种基因的表达

公开(公告)号：US20100069256A1

公开(公告)日：2010-03-18

申请号：US12550703

申请日：2009-08-31

Applicant: Frederic Baribaud ,  Xilin Katherine Li

Inventor： Frederic Baribaud ,  Xilin Katherine Li

IPC: C40B30/04 ,  C07H21/04

CPC classification number: G01N33/68 ,  C12Q1/6883 ,  C12Q2600/106 ,  C12Q2600/156 ,  C12Q2600/158 ,  G01N2800/06 ,  G01N2800/065 ,  G01N2800/52

Abstract: A method for assessment of the suitability of a target therapy for a gastrointestinal-related disorder, such as ulcerative colitis, in a subject evaluates the presence, absence, and/or magnitude of expression of one or more genes in a 20- or 5-member gene panel in a sample. The method enables identification of the effectiveness of target therapies prior to starting a patient on such therapies.

Abstract translation: 用于评估受试者胃肠道相关疾病（例如溃疡性结肠炎）的靶标治疗适用性的方法评估20-或5-位基因中一个或多个基因的表达的存在，不存在和/或大小， 成员基因组在样品中。 该方法能够在开始患者之前鉴定目标疗法的有效性。

公开(公告)号：US20090186772A1

公开(公告)日：2009-07-23

申请号：US12110687

申请日：2008-04-28

Applicant: Frederic Baribaud ,  Xilin Li ,  Keying Ma ,  Xiao-Yu Song

Inventor： Frederic Baribaud ,  Xilin Li ,  Keying Ma ,  Xiao-Yu Song

IPC: C40B30/04 ,  C12Q1/68 ,  C07H21/04

CPC classification number: C12Q1/6883 ,  C12Q2600/106 ,  C12Q2600/158

Abstract: A method for assessment of the suitability of a target therapy for a gastrointestinal-related disorder, such as ulcerative colitis, in a subject evaluates the presence, absence, and/or magnitude of expression of one or more genes in a 19- or 5-member gene panel in a sample. The method enables identification of the effectiveness of target therapies prior to starting a patient on such therapies.

Abstract translation: 用于评估受试者胃肠道相关疾病（例如溃疡性结肠炎）的目标治疗适用性的方法评价19-或5-位中一个或多个基因的表达的存在，不存在和/或大小， 成员基因组在样品中。 该方法能够在开始患者之前鉴定目标疗法的有效性。