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    Markers and Methods for Assessing and Treating Ulcerative Colitis and Related Disorders Using a 43 Gene Panel
    3.
    发明申请
    Markers and Methods for Assessing and Treating Ulcerative Colitis and Related Disorders Using a 43 Gene Panel 审中-公开
    使用43基因面板评估和治疗溃疡性结肠炎和相关疾病的标记和方法

    公开(公告)号：US20080293582A1

    公开(公告)日：2008-11-27

    申请号：US11847737

    申请日：2007-08-30

    Applicant: XILIN LI ,  XIAO-YU SONG

    Inventor： XILIN LI ,  XIAO-YU SONG

    IPC: C40B30/04 ,  C40B30/00 ,  C12Q1/68 ,  G01N33/53

    CPC classification number: C12Q1/6883 ,  C12Q2600/106 ,  C12Q2600/136 ,  C12Q2600/158

    Abstract: A method for prognostic or diagnostic assessment of a gastrointestinal-related disorder, such as ulcerative colitis, in a subject correlates the presence, absence, and/or magnitude of a gene in a sample with a reference standard to determine the presence and/or severity of the disorder, and/or the response to treatment for the disorder. The method enables identification of the effectiveness of candidate therapies.

    Abstract translation: 对受试者胃肠相关疾病如溃疡性结肠炎的预后或诊断性评价的方法将样品中的基因的存在，不存在和/或大小与参考标准相关联，以确定存在和/或严重程度 的病症，和/或对该病症的治疗的反应。 该方法能够识别候选治疗的有效性。

    CNGH0010 specific polynucleotides, polypeptides, antibodies, compositions, methods and uses
    4.
    发明申请
    CNGH0010 specific polynucleotides, polypeptides, antibodies, compositions, methods and uses 有权

    公开(公告)号：US20060141479A1

    公开(公告)日：2006-06-29

    申请号：US10835904

    申请日：2004-04-30

    Applicant: Xiao-Yu Song ,  Chris Huang ,  Keying Ma ,  Bailin Liang ,  Michael Naso

    Inventor： Xiao-Yu Song ,  Chris Huang ,  Keying Ma ,  Bailin Liang ,  Michael Naso

    IPC: C12Q1/68 ,  C07H21/04 ,  C12P21/06 ,  C07K14/47 ,  C07K16/18

    CPC classification number: C07K14/47 ,  A61K45/06

    Abstract: Novel polypeptides (CNGH0010) and antibodies, including specified portions or variants, specific for at least one such CNGH0010 polypeptide, variant, or fragment thereof, as well as nucleic acids encoding such CNGH0010 polypeptides and antibodies, complementary nucleic acids, vectors, host cells, and methods of making and using thereof, are useful for therapeutic and diagnostic formulations, administration and devices. The aforesaid polypeptides can be used to generate human, primate, rodent, mammalian, chimeric, humanized and/or CDR-grafted anti-CNGH0010 antibodies. The CNGH0010 polypeptides and antibodies are used in modulating or treating at least one CNGH0010-related disease in a cell, tissue, organ, animal, or patient. Such diseases may include, but are not limited to, psoriasis, rheumatoid arthritis, emphysema, asthma, diabetes, autoimmune thyroiditis, inflammatory bowel diseases, including Crohn's disease and ulcerative colitis, different types of dermatitis including allergic dermatitis, contact dermatitis, actinic keratosis, wound healing, scar formation, various renal diseases, various respiratory diseases, various diseases of reproductive organs, such as endometriosis, melanoma, squamous cell carcinoma, ovarian cancer, breast cancer, lung cancer, colon cancer, prostate cancer, renal cell carcinoma, Grave's diseases and other inflammatory and hyperproliferative diseases.

    Methods for assessing response to therapy in subjects having ulcerative colitis
    5.
    发明授权
    Methods for assessing response to therapy in subjects having ulcerative colitis 有权
    评估溃疡性结肠炎患者治疗反应的方法

    公开(公告)号：US07943310B2

    公开(公告)日：2011-05-17

    申请号：US11847812

    申请日：2007-08-30

    Applicant: Xilin Li ,  Xiao-yu Song

    Inventor： Xilin Li ,  Xiao-yu Song

    IPC: C12Q1/68 ,  C07H21/02 ,  C07H21/04 ,  C12P19/34

    CPC classification number: C12Q1/6883 ,  C12Q2600/106 ,  C12Q2600/136 ,  C12Q2600/158

    Abstract: A method for prognostic or diagnostic assessment of a gastrointestinal-related disorder, such as ulcerative colitis, in a subject correlates the presence, absence, and/or magnitude of a gene in a sample with a reference standard to determine the presence and/or severity of the disorder, and/or the response to treatment for the disorder. The method enables identification of the effectiveness of candidate therapies.

    Abstract translation: 对受试者胃肠相关疾病如溃疡性结肠炎的预后或诊断性评价的方法将样品中的基因的存在，不存在和/或大小与参考标准相关联，以确定存在和/或严重程度 的病症，和/或对该病症的治疗的反应。 该方法能够识别候选治疗的有效性。

    Markers and Methods for Assessing and Treating Ulcerative Colitis and Related Disorders Using 66 Gene Panel
    7.
    发明申请
    Markers and Methods for Assessing and Treating Ulcerative Colitis and Related Disorders Using 66 Gene Panel 有权
    使用66基因面板评估和治疗溃疡性结肠炎和相关疾病的标记和方法

    公开(公告)号：US20090054253A1

    公开(公告)日：2009-02-26

    申请号：US11847812

    申请日：2007-08-30

    Applicant: Xilin Li ,  Xiao-yu Song

    Inventor： Xilin Li ,  Xiao-yu Song

    IPC: C40B30/04 ,  C07H21/04 ,  C12Q1/68

    CPC classification number: C12Q1/6883 ,  C12Q2600/106 ,  C12Q2600/136 ,  C12Q2600/158

    Abstract: A method for prognostic or diagnostic assessment of a gastrointestinal-related disorder, such as ulcerative colitis, in a subject correlates the presence, absence, and/or magnitude of a gene in a sample with a reference standard to determine the presence and/or severity of the disorder, and/or the response to treatment for the disorder. The method enables identification of the effectiveness of candidate therapies.

    Abstract translation: 对受试者胃肠相关疾病如溃疡性结肠炎的预后或诊断性评价的方法将样品中的基因的存在，不存在和/或大小与参考标准相关联，以确定存在和/或严重程度 的病症，和/或对该病症的治疗的反应。 该方法能够识别候选治疗的有效性。

    CNGH0010 Specific Polynucleotides, Polypeptides, Antibodies, Compositions, Methods and Uses
    8.
    发明申请
    CNGH0010 Specific Polynucleotides, Polypeptides, Antibodies, Compositions, Methods and Uses 有权
    CNGH0010特异性多核苷酸，多肽，抗体，组合物，方法和用途

    公开(公告)号：US20080044422A1

    公开(公告)日：2008-02-21

    申请号：US11680113

    申请日：2007-02-28

    Applicant: Xiao-yu Song ,  Chong Huang ,  Keying Ma ,  Bailin Liang ,  Michael Naso

    Inventor： Xiao-yu Song ,  Chong Huang ,  Keying Ma ,  Bailin Liang ,  Michael Naso

    IPC: A61K31/70 ,  A01K67/00 ,  A61K38/00 ,  A61K39/395 ,  A61P43/00 ,  C07K14/00 ,  C07K16/18 ,  C12N1/00 ,  C12N1/20 ,  C12N15/00 ,  C12N15/11 ,  C12N15/82 ,  C12N5/06 ,  C12P21/04 ,  C12Q1/68 ,  G01N33/00

    CPC classification number: C07K14/47 ,  A61K38/00 ,  A61K45/06 ,  A61K2039/505 ,  C07K16/18 ,  C07K2317/92 ,  C12Q1/6883 ,  C12Q2600/158

    Abstract: Novel polypeptides (CNGH0010) and antibodies, including specified portions or variants, specific for at least one such CNGH0010 polypeptide, variant, or fragment thereof, as well as nucleic acids encoding such CNGH0010 polypeptides and antibodies, complementary nucleic acids, vectors, host cells, and methods of making and using thereof, are useful for therapeutic and diagnostic formulations, administration and devices. The aforesaid polypeptides can be used to generate human, primate, rodent, mammalian, chimeric, humanized and/or CDR-grafted anti-CNGH0010 antibodies. The CNGH0010 polypeptides and antibodies are used in modulating or treating at least one CNGH0010-related disease in a cell, tissue, organ, animal, or patient. Such diseases may include, but are not limited to, psoriasis, rheumatoid arthritis, emphysema, asthma, diabetes, autoimmune thyroiditis, inflammatory bowel diseases, including Crohn's disease and ulcerative colitis, different types of dermatitis including allergic dermatitis, contact dermatitis, actinic keratosis, wound healing, scar formation, various renal diseases, various respiratory diseases, various diseases of reproductive organs, such as endometriosis, melanoma, squamous cell carcinoma, ovarian cancer, breast cancer, lung cancer, colon cancer, prostate cancer, renal cell carcinoma, Grave's diseases and other inflammatory and hyperproliferative diseases.

    Abstract translation: 对于至少一个这样的CNGH0010多肽，其变体或片段，以及编码这样的CNGH0010多肽和抗体，互补核酸，载体，宿主细胞的核酸，对于至少一个这样的CNGH0010多肽，变体或其片段特异的新型多肽（CNGH0010）和抗体，包括特定部分或变体， 其制备和使用方法可用于治疗和诊断制剂，给药和装置。 上述多肽可用于产生人，灵长类动物，啮齿动物，哺乳动物，嵌合，人源化和/或CDR移植抗CNGH0010抗体。 CNGH0010多肽和抗体用于调节或治疗细胞，组织，器官，动物或患者中的至少一种CNGH0010相关疾病。 这些疾病可以包括但不限于牛皮癣，类风湿性关节炎，肺气肿，哮喘，糖尿病，自身免疫性甲状腺炎，包括克罗恩病和溃疡性结肠炎在内的炎性肠病，不同类型的皮炎，包括过敏性皮炎，接触性皮炎，光化性角化病， 伤口愈合，瘢痕形成，各种肾脏疾病，各种呼吸道疾病，生殖器官的各种疾病，如子宫内膜异位症，黑素瘤，鳞状细胞癌，卵巢癌，乳腺癌，肺癌，结肠癌，前列腺癌，肾细胞癌，Grave's 疾病等炎症和过度增生性疾病。

    CNGH0010 specific polynucleotides, polypeptides, antibodies, compositions, methods and uses
    9.
    发明授权
    CNGH0010 specific polynucleotides, polypeptides, antibodies, compositions, methods and uses 有权
    CNGH0010特异性多核苷酸，多肽，抗体，组合物，方法和用途

    公开(公告)号：US07326687B2

    公开(公告)日：2008-02-05

    申请号：US10835904

    申请日：2004-04-30

    Applicant: Xiao-Yu Song ,  Chris Huang ,  Keying Ma ,  Bailin Liang ,  Michael Naso

    Inventor： Xiao-Yu Song ,  Chris Huang ,  Keying Ma ,  Bailin Liang ,  Michael Naso

    IPC: A61K38/17 ,  C07K14/435

    CPC classification number: C07K14/47 ,  A61K45/06

    Abstract: Novel polypeptides (CNGH0010) and antibodies, including specified portions or variants, specific for at least one such CNGH0010 polypeptide, variant, or fragment thereof, as well as nucleic acids encoding such CNGH0010 polypeptides and antibodies, complementary nucleic acids, vectors, host cells, and methods of making and using thereof, are useful for therapeutic and diagnostic formulations, administration and devices. The aforesaid polypeptides can be used to generate human, primate, rodent, mammalian, chimeric, humanized and/or CDR-grafted anti-CNGH0010 antibodies. The CNGH0010 polypeptides and antibodies are used in modulating or treating at least one CNGH0010-related disease in a cell, tissue, organ, animal, or patient. Such diseases may include, but are not limited to, psoriasis, rheumatoid arthritis, emphysema, asthma, diabetes, autoimmune thyroiditis, inflammatory bowel diseases, including Crohn's disease and ulcerative colitis, different types of dermatitis including allergic dermatitis, contact dermatitis, actinic keratosis, wound healing, scar formation, various renal diseases, various respiratory diseases, various diseases of reproductive organs, such as endometriosis, melanoma, squamous cell carcinoma, ovarian cancer, breast cancer, lung cancer, colon cancer, prostate cancer, renal cell carcinoma, Grave's diseases and other inflammatory and hyperproliferative diseases.

    Abstract translation: 对于至少一个这样的CNGH0010多肽，其变体或片段，以及编码这样的CNGH0010多肽和抗体，互补核酸，载体，宿主细胞的核酸，对于至少一个这样的CNGH0010多肽，变体或其片段特异的新型多肽（CNGH0010）和抗体，包括特定部分或变体， 其制备和使用方法可用于治疗和诊断制剂，给药和装置。 上述多肽可用于产生人，灵长类动物，啮齿动物，哺乳动物，嵌合，人源化和/或CDR移植抗CNGH0010抗体。 CNGH0010多肽和抗体用于调节或治疗细胞，组织，器官，动物或患者中的至少一种CNGH0010相关疾病。 这些疾病可以包括但不限于牛皮癣，类风湿性关节炎，肺气肿，哮喘，糖尿病，自身免疫性甲状腺炎，包括克罗恩病和溃疡性结肠炎在内的炎性肠病，不同类型的皮炎，包括过敏性皮炎，接触性皮炎，光化性角化病， 伤口愈合，瘢痕形成，各种肾脏疾病，各种呼吸道疾病，生殖器官的各种疾病，如子宫内膜异位症，黑素瘤，鳞状细胞癌，卵巢癌，乳腺癌，肺癌，结肠癌，前列腺癌，肾细胞癌，Grave's 疾病等炎症和过度增生性疾病。

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