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公开(公告)号：US09238042B2
公开(公告)日：2016-01-19
申请号：US13107528
申请日：2011-05-13
IPC分类号： A61K49/00 , C12Q1/70 , A61K31/713 , C12N15/113 , A01K67/027 , G01N33/50 , G01N33/569 , G01N33/68
CPC分类号： A61K31/713 , A01K67/027 , A01K2267/03 , C12N15/1136 , C12N15/1138 , C12N2310/11 , C12N2310/3233 , C12N2310/3513 , C12N2320/33 , G01N33/5041 , G01N33/56983 , G01N33/6893 , G01N2333/005 , G01N2333/54 , G01N2500/00 , Y02A50/414
摘要： Provided are antisense oligonucleotides and other agents that target and modulate IL-17 and/or IL-23 signaling activity in a cell, compositions that comprise the same, and methods of use thereof. Also provided are animal models for identifying agents that modulate 17 and/or IL-23 signaling activity.
摘要翻译： 提供靶向和调节细胞中IL-17和/或IL-23信号传导活性的反义寡核苷酸和其它试剂，包含其的组合物及其使用方法。 还提供了用于鉴定调节17和/或IL-23信号传导活性的药剂的动物模型。
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公开(公告)号：US20110289608A1
公开(公告)日：2011-11-24
申请号：US13107528
申请日：2011-05-13
IPC分类号： A61P11/06 , A61K31/7125 , C07H21/04 , C07K2/00 , C07K9/00 , A61K49/00 , A61P29/00 , A61P37/02 , A61P19/02 , A61P17/06 , A61P9/10 , A61P35/00 , A61P11/00 , A61P35/02 , C12Q1/06 , C12Q1/70 , C12N5/071
CPC分类号： A61K31/713 , A01K67/027 , A01K2267/03 , C12N15/1136 , C12N15/1138 , C12N2310/11 , C12N2310/3233 , C12N2310/3513 , C12N2320/33 , G01N33/5041 , G01N33/56983 , G01N33/6893 , G01N2333/005 , G01N2333/54 , G01N2500/00 , Y02A50/414
摘要： Provided are antisense oligonucleotides and other agents that target and modulate IL-17 and/or IL-23 signaling activity in a cell, compositions that comprise the same, and methods of use thereof. Also provided are animal models for identifying agents that modulate 17 and/or IL-23 signaling activity.
摘要翻译： 提供靶向和调节细胞中IL-17和/或IL-23信号传导活性的反义寡核苷酸和其它试剂，包含其的组合物及其使用方法。 还提供了用于鉴定调节17和/或IL-23信号传导活性的药剂的动物模型。
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