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公开(公告)号：US4855162A
公开(公告)日：1989-08-08
申请号：US74635
申请日：1987-07-17
IPC分类号： B01D67/00 , B01D71/36 , B01D71/68 , B05D7/02 , C08J3/03 , C08J7/04 , C08J9/42 , D06M13/02 , D06M13/188 , D06M15/256
CPC分类号： B01D67/0088 , B05D7/02 , C08J3/03 , C08J7/047 , C08J2327/18 , C08J2427/00
摘要： Adherent, PTFE coatings on polymer surfaces can be produced at temperatures well below the sintering temperature of PTFE, by contacting the surface with a dilute dispersion of PTFE particles and heating the surface to its softening point (in the vicinity of its glass transition temperature) to dry it and to cause the individual particles to become embedded in and surrounded by the polymer.
摘要翻译： 聚合物表面上的粘附的PTFE涂层可以在远低于PTFE的烧结温度的温度下生产，通过使PTFE表面与PTFE颗粒的稀释分散体接触并将表面加热到其软化点（在其玻璃化转变温度附近）至 干燥并使单个颗粒嵌入聚合物并被聚合物包围。
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公开(公告)号：US4743496A
公开(公告)日：1988-05-10
申请号：US814301
申请日：1985-12-30
CPC分类号： D06Q1/02 , B01D39/083 , B29C71/0009 , B29D28/005 , B01D2239/0421 , B01D2239/0636 , B29L2031/737 , Y10T442/179
摘要： A fabric of a polymer material useful for filtration and other purposes can be treated with a mixture of a solvent for the polymer material in a liquid which is not a solvent for the polymer material and which is more volatile than the solvent for a time and at a temperature sufficient to dissolve some polymer material in the strands. As this occurs the surface tension of the dissolved polymer will cause the dissolved polymer to move to create a continuous, smooth walled, curved surface connecting adjacent strands and extending between such strands.
摘要翻译： 可用于过滤和其它目的的聚合物材料的织物可以用聚合物材料的溶剂的混合物处理，所述溶剂在不是聚合物材料的溶剂的液体中并且比溶剂在一段时间内更易挥发， 足以溶解股线中的一些聚合物材料的温度。 当这种情况发生时，溶解的聚合物的表面张力将导致溶解的聚合物移动以产生连接相邻的股线并在这些股线之间延伸的连续的，平滑的，弯曲的曲面。
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公开(公告)号：US5057421A
公开(公告)日：1991-10-15
申请号：US334321
申请日：1989-04-07
摘要： An enzyme reactor system is provided based on the entrapment of a coenzyme-requiring enzyme, a coenzyme, and a regeneration enzyme in a hydrogel layer coated on a support, and confined by an ultraporous thin film semipermeable membrane. The diffusion barrier confines the coenzyme-requiring enzyme, coenzyme, and regeneration enzyme but lets substrate and reaction products, exclusive of coenzyme, diffuse freely into and out of the hydrogel layer. In an alternate embodiment, the support is formed of an ultraporous thin film semipermeable membrane on a microporous or macroporous support, through which the reaction products, exclusive of coenzyme, can diffuse freely, but through which neither coenzyme-requiring enzyme, coenzyme, regeneration enzyme, nor substrate can pass. In this embodiment, the product is recovered in high purity, free of substrate, coenzyme-requiring enzyme, coenzyme, and regeneration enzyme. A constant supply of coenzyme for the enzyme reaction is assured by initially charging the hydrogel layer with an adequate supply of coenzyme. The problem of coenzyme depletion is solved by including a second enzyme in the hydrogel layer which regenerates the used coenzyme, thus recycling it. The substrates for both the primary and regeneration reactions are supplied in the circulating solvent. Reaction products, exclusive of coenzyme, are carried away by the solvent.
摘要翻译： 提供了一种酶反应器系统，其基于在包被在载体上的水凝胶层中夹带辅酶需要酶，辅酶和再生酶，并被超薄膜半透膜限制。 扩散屏障限制需要辅酶的酶，辅酶和再生酶，但是让辅助基质和反应产物自由扩散进入和流出水凝胶层。 在一个替代实施方案中，载体由微孔或大孔载体上的超蒸气薄膜半透膜形成，除辅酶外，反应产物可以自由扩散，但不需要辅酶的酶，辅酶，再生酶 ，也不能通过底物。 在该实施方案中，产物以高纯度回收，不含底物，需要辅酶，辅酶和再生酶。 通过用足够的辅酶供应首先给水凝胶层充电，可确保酶反应的恒定供应辅酶。 通过在水凝胶层中包含再生所用辅酶的第二种酶来解决辅酶消耗问题，从而回收辅酶。 用于初级和再生反应的底物都在循环溶剂中供应。 不含辅酶的反应产物被溶剂带走。
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公开(公告)号：US4956289A
公开(公告)日：1990-09-11
申请号：US026380
申请日：1987-03-16
CPC分类号： C12M25/14 , C12M21/18 , C12M29/04 , Y10S435/817
摘要： An enzyme reactor system is provided based on the entrapment of an enzyme in a hydrogel layer coated on a support, and confined by an ultraporous thin film membrane diffusion barrier. The diffusion barrier confines the enzyme, but lets substrate and reaction products diffuse feeely into and out of the hydrogel layer. In an alternate embodiment, the support is formed of an ultraporous thin film membrane diffusion barrier on a microporous or macroporous support, through which the reaction products can diffuse freely, but through which neither enzyme nor substrate can pass. In this embodiment, the product is recovered in high purity, free of substrate and enzyme.
摘要翻译： 提供了一种酶反应器系统，其基于在包被在载体上的水凝胶层中夹带酶，并被超薄膜扩散阻挡层限制。 扩散屏障限制酶，但使底物和反应产物进入和流出水凝胶层。 在另一个实施方案中，载体由微孔或大孔载体上的超蒸发薄膜扩散阻挡层形成，反应产物可以自由扩散，而酶和底物都不能通过。 在该实施方案中，产物以高纯度回收，不含底物和酶。
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公开(公告)号：US4853128A
公开(公告)日：1989-08-01
申请号：US183056
申请日：1988-04-19
CPC分类号： D04H1/46 , A61L2/26 , B01D63/081 , B01D63/082 , B01D69/10
摘要： In applications involving interleaving membranes with separators, for bioreactors, dialyzers, and membrane filters and the like, shrinkage of the separator, preferably made of polypropylene, polyamides, or polyethylene terephthlate fiber web, is avoided, and the need for the use of exotic and expensive fluorinated hydrocarbon polymer materials for such separators is avoided by subjecting the separator to untensioned heating at temperatures of from about b 120 l degrees C., up to a temperature less than the glass transition or melting temperature of the polymer web under wet steam at a pressure of from about 1.0 to about 2.0 atmospheres for a time of at least about 20 minutes.
摘要翻译： 在涉及用分离器交织膜的应用中，对于生物反应器，透析器和膜过滤器等，避免了优选由聚丙烯，聚酰胺或聚对苯二甲酸乙二醇酯纤维网制成的隔膜的收缩，并且需要使用外来和 通过使分离器在约120℃，在低于在湿蒸汽下的聚合物纤维网的玻璃化转变温度或熔融温度的温度下在约120℃下进行未张力加热来避免用于这种分离器的昂贵的氟化烃聚合物材料 压力为约1.0至约2.0大气压至少约20分钟的时间。
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公开(公告)号：US4937196A
公开(公告)日：1990-06-26
申请号：US395655
申请日：1989-08-18
摘要： A bioreactor is disclosed in which cells are confined to a compartment formed by porous hydrophyllic sheet membranes through which a nutrient solution diffuses in and exocellular products and metabolic waste diffuse out. Adjacent gas compartments allow the flow of free oxygen into the cell compartment. Each cell compartment is configured to place cells within about 100-200 micrometers of the oxygen transport membrane.
摘要翻译： 公开了一种生物反应器，其中细胞被限制在由多孔亲水片膜形成的隔室中，营养溶液通过其渗透并通过外部细胞产物和代谢废物扩散出去。 相邻的气体隔间允许游离氧气流入细胞室。 每个细胞室配置成将细胞置于氧传输膜的约100-200微米内。
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