公开(公告)号：US20070275962A1

公开(公告)日：2007-11-29

申请号：US10597120

申请日：2004-09-10

申请人： Anil Koul ,  Bert Klebl ,  Gerhard Muller ,  Andrea Missio ,  Wilfried Schwab ,  Doris Hafenbradl ,  Lars Neumann ,  Marc-Nicola Sommer ,  Stefan Muller ,  Edmund Hoppe ,  Achim Freisleben ,  Alexander Backes ,  Christian Hartung ,  Beatrice Felber ,  Birgit Zech ,  Ola Engkvist ,  Gyorgy Keri ,  Laszlo Orfi ,  Peter Banhegyi ,  Zoltan Greff ,  Zoltan Horvath ,  Zoltan Varga ,  Peter Marko ,  Janos Pato ,  Istvan Szabadkai ,  Zsolt Szekelyhid ,  Frigyes Waczek

发明人： Anil Koul ,  Bert Klebl ,  Gerhard Muller ,  Andrea Missio ,  Wilfried Schwab ,  Doris Hafenbradl ,  Lars Neumann ,  Marc-Nicola Sommer ,  Stefan Muller ,  Edmund Hoppe ,  Achim Freisleben ,  Alexander Backes ,  Christian Hartung ,  Beatrice Felber ,  Birgit Zech ,  Ola Engkvist ,  Gyorgy Keri ,  Laszlo Orfi ,  Peter Banhegyi ,  Zoltan Greff ,  Zoltan Horvath ,  Zoltan Varga ,  Peter Marko ,  Janos Pato ,  Istvan Szabadkai ,  Zsolt Szekelyhid ,  Frigyes Waczek

IPC分类号： C07D495/04 ,  A61P31/04 ,  C07D209/42 ,  C07D333/66 ,  C07D333/68 ,  C07D495/10 ,  C07D409/12 ,  C07D413/14 ,  C07D491/04 ,  C07D493/04

CPC分类号： C07D409/12 ,  C07D209/42 ,  C07D333/66 ,  C07D333/68 ,  C07D491/04 ,  C07D493/04 ,  C07D495/04 ,  C07D495/10

摘要： Described are heterobicyclic compounds such as 4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid amides, 4,7-dihydro-5H-thieno[2,3-c]thiopyran 3-carboxylic acid amides, 4,7-dihydro-5H-thieno[2,3-c]pyran-3-carboxylic acid amides, or benzo[b]thiophene-3-carboxylic acid amides and pharmaceutically acceptable salts thereof, the use of these derivatives for the prophylaxis and/or treatment of various diseases such as infectious diseases, including mycobacteriainduced infections and opportunistic diseases, prion diseases, immunological diseases, autoimmune diseases, bipolar and clinical disorders, cardiovascular diseases, cell proliferative diseases, diabetes, inflammation, transplant rejections, erectile dysfunction, neurodegenerative diseases and stroke, as well as compositions containing at least one heterobicyclic compound and/or pharmaceutically acceptable salts thereof. Furthermore, reaction procedures for the synthesis of the heterobicyclic compound are disclosed.

摘要翻译： 描述的是杂双环化合物，例如4,5,6,7-四氢苯并[b]噻吩-3-羧酸酰胺，4,7-二氢-5H-噻吩并[2,3-c]噻喃-3-羧酸酰胺，4 ，7-二氢-5H-噻吩并[2,3-c]吡喃-3-羧酸酰胺或苯并[b]噻吩-3-羧酸酰胺及其药学上可接受的盐，这些衍生物用于预防和 /或治疗诸如感染性疾病，包括分泌细菌感染和机会性疾病，朊病毒疾病，免疫疾病，自身免疫疾病，双相和临床病症，心血管疾病，细胞增殖性疾病，糖尿病，炎症，移植排斥，勃起功能障碍，神经变性 疾病和中风，以及含有至少一种杂双环化合物和/或其药学上可接受的盐的组合物。 此外，公开了用于合成杂双环化合物的反应程序。

公开(公告)号：US20080214583A1

公开(公告)日：2008-09-04

申请号：US11587851

申请日：2005-04-25

申请人： Janos Szolcsanyi ,  Laszlo Orfi ,  Gyorgy Keri ,  Frigyes Waczek ,  Erika Pinter ,  Zsusanna Helyes ,  Tamas Szuts ,  Jozsef Nemeth

发明人： Janos Szolcsanyi ,  Laszlo Orfi ,  Gyorgy Keri ,  Frigyes Waczek ,  Erika Pinter ,  Zsusanna Helyes ,  Tamas Szuts ,  Jozsef Nemeth

IPC分类号： A61K31/519 ,  C07D487/04 ,  A61P19/08 ,  A61P19/02 ,  A61P25/00 ,  A61P29/00

CPC分类号： C07D487/04

摘要： The invention relates to new 7H-pyrrolo[2,3-d]pyrimidine derivatives, as well as their therapeutically acceptable salts, pharmaceutical preparations containing them and process for producing the active agent. The pharmaceutical preparation is adventageously antiphlogistic and analgetic one, a preparation reducing neuropathic hyperalgesia and rheumatic arthritis, a preparation for hindering destruction of bones chondrus, being applicable for treatment of other diseases, which may be connected with other inflammatory processes e.g. asthma, eczema or psoriasis.

摘要翻译： 本发明涉及新的7H-吡咯并[2,3-d]嘧啶衍生物及其治疗上可接受的盐，含有它们的药物制剂和生产活性剂的方法。 药物制剂是抗炎和止痛药物，减轻神经性痛觉过敏和风湿性关节炎的制剂，用于阻止骨骼软骨破坏的制剂，可用于治疗其它疾病，其可与其它炎症过程相关，例如与其它炎症过程相关。 哮喘，湿疹或牛皮癣。

公开(公告)号：US20050203155A1

公开(公告)日：2005-09-15

申请号：US11030538

申请日：2005-01-05

申请人： Konstadinos Salassidis ,  Alexander Kurtenbach ,  Henrik Daub ,  Sabine Obert ,  Zoltan Greff ,  Gyorgy Keri ,  Laszlo Orfi ,  Frigyes Waczek

发明人： Konstadinos Salassidis ,  Alexander Kurtenbach ,  Henrik Daub ,  Sabine Obert ,  Zoltan Greff ,  Gyorgy Keri ,  Laszlo Orfi ,  Frigyes Waczek

IPC分类号： A61K31/4178 ,  A61P31/20 ,  C07D233/54 ,  C07D233/64 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D405/04 ,  C07D405/14 ,  C07D409/04 ,  C07D409/14 ,  A61K31/424 ,  A61K31/4184 ,  C07D413/02 ,  C07D43/02

CPC分类号： C07D233/64 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D405/04 ,  C07D405/14 ,  C07D409/04 ,  C07D409/14

摘要： Novel imidazole compounds particularly useful against Hepatitis C Virus infections and diseases associated therewith are described. Applications of the human cellular proteins casein kinase I alpha (α), delta (δ), and epsilon (ε) as targets for medical intervention against Hepatitis C Virus (HCV) infections and diseases are also described. This invention further refers to a method for identifying compounds useful for the prophylaxis and/or treatment of Hepatitis C Virus infections and diseases, methods for treating Hepatitis C Virus infections and diseases, as well as pharmaceutical compositions useful for the prophylaxis and/or treatment of Hepatitis C Virus infections and diseases. Moreover, disclosed are antibodies, oligonucleotides and specific compounds which are effective for the detection, prophylaxis and/or treatment of Hepatitis C Virus infections and diseases. Solid supports useful for the identification of compounds suitable for preventing and/or treating Hepatitis C Virus infections and diseases are also disclosed.

摘要翻译： 对丙型肝炎病毒感染和与之相关疾病特别有用的新型咪唑化合物进行了描述。 还描述了人细胞蛋白质酪蛋白激酶Iα（α），δ（delta）和ε（ε）作为医疗干预对丙型肝炎病毒（HCV）感染和疾病的靶标的应用。 本发明还涉及用于鉴定可用于预防和/或治疗丙型肝炎病毒感染和疾病的化合物的方法，用于治疗丙型肝炎病毒感染和疾病的方法，以及可用于预防和/或治疗丙型肝炎病毒感染和/ 丙型肝炎病毒感染和疾病。 此外，公开了对丙型肝炎病毒感染和疾病的检测，预防和/或治疗有效的抗体，寡核苷酸和特异性化合物。 用于鉴定适合于预防和/或治疗丙型肝炎病毒感染的化合物的固体支持物也被公开。

公开(公告)号：US20090018149A1

公开(公告)日：2009-01-15

申请号：US10510791

申请日：2003-04-09

申请人： Andrea Missio ,  Gerald Bacher ,  Anil Koul ,  Axel Choidas ,  Peter Banhegyi ,  Zoltan Greff ,  Gyorgy Keri ,  Peter Marko ,  Laszlo Orfi ,  Janos Pato ,  Frigyes Waczek

发明人： Andrea Missio ,  Gerald Bacher ,  Anil Koul ,  Axel Choidas ,  Peter Banhegyi ,  Zoltan Greff ,  Gyorgy Keri ,  Peter Marko ,  Laszlo Orfi ,  Janos Pato ,  Frigyes Waczek

IPC分类号： A61K31/381 ,  A61P31/04 ,  A61P31/12 ,  C07D333/52 ,  C07D409/02 ,  G01N33/53 ,  A61K31/4178 ,  C07D495/02 ,  A61K31/519 ,  A61K31/4535

CPC分类号： C07D409/12 ,  C07D333/66 ,  C07D333/68 ,  C07D409/14 ,  C07D495/04 ,  C07D495/14

摘要： Described are 4,5,6,7-tetrahydrobenzo[b]thiophene derivatives and pharmaceutically acceptable salts thereof, the use of these derivatives for the prophylaxis and/or treatment of mycobacteria-induced infections and opportunistic infections, as well as compositions containing at least one 4,5,6,7-tetrahydrobenzo[b]thiophene derivative and/or pharmaceutically acceptable salts thereof. Furthermore, the present application refers to the use of mycobacterial protein serine/threonine kinases for developing methods for detection and determination of these kinases for recognising and monitoring diseases and for controlling therapy of diseases.

摘要翻译： 描述了4,5,6,7-四氢苯并[b]噻吩衍生物及其药学上可接受的盐，这些衍生物用于预防和/或治疗分枝杆菌诱导的感染和机会性感染，以及至少含有 一种4,5,6,7-四氢苯并[b]噻吩衍生物和/或其药学上可接受的盐。 此外，本申请是指使用分枝杆菌蛋白丝氨酸/苏氨酸激酶来开发用于检测和测定这些用于识别和监测疾病和控制疾病治疗的这些激酶的方法。