公开(公告)号：US20070275962A1

公开(公告)日：2007-11-29

申请号：US10597120

申请日：2004-09-10

申请人： Anil Koul ,  Bert Klebl ,  Gerhard Muller ,  Andrea Missio ,  Wilfried Schwab ,  Doris Hafenbradl ,  Lars Neumann ,  Marc-Nicola Sommer ,  Stefan Muller ,  Edmund Hoppe ,  Achim Freisleben ,  Alexander Backes ,  Christian Hartung ,  Beatrice Felber ,  Birgit Zech ,  Ola Engkvist ,  Gyorgy Keri ,  Laszlo Orfi ,  Peter Banhegyi ,  Zoltan Greff ,  Zoltan Horvath ,  Zoltan Varga ,  Peter Marko ,  Janos Pato ,  Istvan Szabadkai ,  Zsolt Szekelyhid ,  Frigyes Waczek

发明人： Anil Koul ,  Bert Klebl ,  Gerhard Muller ,  Andrea Missio ,  Wilfried Schwab ,  Doris Hafenbradl ,  Lars Neumann ,  Marc-Nicola Sommer ,  Stefan Muller ,  Edmund Hoppe ,  Achim Freisleben ,  Alexander Backes ,  Christian Hartung ,  Beatrice Felber ,  Birgit Zech ,  Ola Engkvist ,  Gyorgy Keri ,  Laszlo Orfi ,  Peter Banhegyi ,  Zoltan Greff ,  Zoltan Horvath ,  Zoltan Varga ,  Peter Marko ,  Janos Pato ,  Istvan Szabadkai ,  Zsolt Szekelyhid ,  Frigyes Waczek

IPC分类号： C07D495/04 ,  A61P31/04 ,  C07D209/42 ,  C07D333/66 ,  C07D333/68 ,  C07D495/10 ,  C07D409/12 ,  C07D413/14 ,  C07D491/04 ,  C07D493/04

CPC分类号： C07D409/12 ,  C07D209/42 ,  C07D333/66 ,  C07D333/68 ,  C07D491/04 ,  C07D493/04 ,  C07D495/04 ,  C07D495/10

摘要： Described are heterobicyclic compounds such as 4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid amides, 4,7-dihydro-5H-thieno[2,3-c]thiopyran 3-carboxylic acid amides, 4,7-dihydro-5H-thieno[2,3-c]pyran-3-carboxylic acid amides, or benzo[b]thiophene-3-carboxylic acid amides and pharmaceutically acceptable salts thereof, the use of these derivatives for the prophylaxis and/or treatment of various diseases such as infectious diseases, including mycobacteriainduced infections and opportunistic diseases, prion diseases, immunological diseases, autoimmune diseases, bipolar and clinical disorders, cardiovascular diseases, cell proliferative diseases, diabetes, inflammation, transplant rejections, erectile dysfunction, neurodegenerative diseases and stroke, as well as compositions containing at least one heterobicyclic compound and/or pharmaceutically acceptable salts thereof. Furthermore, reaction procedures for the synthesis of the heterobicyclic compound are disclosed.

摘要翻译： 描述的是杂双环化合物，例如4,5,6,7-四氢苯并[b]噻吩-3-羧酸酰胺，4,7-二氢-5H-噻吩并[2,3-c]噻喃-3-羧酸酰胺，4 ，7-二氢-5H-噻吩并[2,3-c]吡喃-3-羧酸酰胺或苯并[b]噻吩-3-羧酸酰胺及其药学上可接受的盐，这些衍生物用于预防和 /或治疗诸如感染性疾病，包括分泌细菌感染和机会性疾病，朊病毒疾病，免疫疾病，自身免疫疾病，双相和临床病症，心血管疾病，细胞增殖性疾病，糖尿病，炎症，移植排斥，勃起功能障碍，神经变性 疾病和中风，以及含有至少一种杂双环化合物和/或其药学上可接受的盐的组合物。 此外，公开了用于合成杂双环化合物的反应程序。

公开(公告)号：US20080207677A1

公开(公告)日：2008-08-28

申请号：US11813236

申请日：2006-01-02

申请人： Stefan Muller ,  Wilfried Schwab ,  Bert Klebl ,  Doris Hafenbradl ,  Edmund Hoppe ,  Zoltan Horvath ,  Gyorgy Keri ,  Zoltan Varga ,  Laszlo Orfi ,  Jeno Marosfalvi ,  Gerhard Muller

发明人： Stefan Muller ,  Wilfried Schwab ,  Bert Klebl ,  Doris Hafenbradl ,  Edmund Hoppe ,  Zoltan Horvath ,  Gyorgy Keri ,  Zoltan Varga ,  Laszlo Orfi ,  Jeno Marosfalvi ,  Gerhard Muller

IPC分类号： A61K31/4375 ,  C07D471/04 ,  A61P35/00

CPC分类号： C07D471/04

摘要： The present invention relates to compounds having a naphthyridine scaffold, and stereoisomeric forms, prodrugs, solvates, hydrates and/or pharmaceutically acceptable salts of these compounds as well as pharmaceutical compositions containing at least one of these naphthyridine derivatives together with pharmaceutically acceptable carrier, excipient and/or diluents. Said naphthyridine compounds have been identified as inhibitors of the protein kinase ROCK2, also known as Rho-kinase, and are useful for the treatment of cancers (tumor growth and metastases), erectile dysfunction, cardiovascular diseases, hypertension, angina pectoris, cerebral ischaemia, cerebral vasospasm, myocardial ischaemia, coronary vasospasm, heart failure, myocardial hypertrophy, atherosclerosis, restenosis, spinal cord injuries, neuronal degeneration, thrombotic disorders, asthma, glaucoma, inflammation, anti-viral diseases (e.g. HIV), and osteoporosis.

摘要翻译： 本发明涉及具有萘啶支架的化合物，以及这些化合物的立体异构形式，前体药物，溶剂合物，水合物和/或药学上可接受的盐，以及含有这些萘啶衍生物中至少一种以及药学上可接受的载体，赋形剂和 /或稀释剂。 所述萘啶化合物已被鉴定为蛋白激酶ROCK2（也称为Rho-激酶）的抑制剂，可用于治疗癌症（肿瘤生长和转移），勃起功能障碍，心血管疾病，高血压，心绞痛，脑缺血， 脑血管痉挛，心肌缺血，冠状动脉血管痉挛，心力衰竭，心肌肥大，动脉粥样硬化，再狭窄，脊髓损伤，神经元变性，血栓形成障碍，哮喘，青光眼，炎症，抗病毒疾病（例如HIV）和骨质疏松症。

公开(公告)号：US20050183781A1

公开(公告)日：2005-08-25

申请号：US11042022

申请日：2005-01-25

申请人： Tamas Vitalis ,  Zoltan Horvath

发明人： Tamas Vitalis ,  Zoltan Horvath

IPC分类号： F02D33/00 ,  F02M37/00 ,  F02M37/02 ,  F02M37/10 ,  F04F5/10 ,  F04F5/46 ,  F04B23/04 ,  B01D47/02 ,  F02M37/04

CPC分类号： F02M37/0094 ,  B60K2015/03118 ,  B60K2015/03138 ,  F02D33/006 ,  F02M37/025 ,  F02M37/106 ,  F04F5/10 ,  F04F5/46 ,  F04F5/464 ,  Y10T137/86075

摘要： The present invention relates to a jet pump having a first inlet duct, a second inlet duct and an outlet duct having an outlet end, wherein the ducts are in fluid communication with each other at a central volume portion. The jet pump also includes a sleeve formed with a closed end at the bottom and partially enclosing said outlet duct. The sleeve has a lateral opening therein at a predetermined height above the outlet end of said outlet duct. A continuous flowpath with different flow directions is also present within the sleeve along the inner and outer surfaces of said outlet duct towards the lateral opening. The jet pump can be advantageously used in fuel delivery system with saddle fuel tanks.

摘要翻译： 本发明涉及一种具有第一入口管道，第二入口管道和具有出口端的出口管道的喷射泵，其中管道在中心体积部分处于彼此流体连通。 喷射泵还包括在底部形成有封闭端并部分地包围所述出口管的套筒。 所述套筒在所述出口管的出口端上方的预定高度处具有侧向开口。 沿着所述出口管道的内表面和外表面的套筒内也存在不同流动方向的连续流路朝向侧向开口。 喷射泵可以有利地用于具有鞍形燃料箱的燃料输送系统中。

公开(公告)号：US4555634A

公开(公告)日：1985-11-26

申请号：US439059

申请日：1982-11-03

申请人： Jurg Muggli ,  Heinz Guttinger ,  Zoltan Horvath

发明人： Jurg Muggli ,  Heinz Guttinger ,  Zoltan Horvath

IPC分类号： G01N21/53 ,  G08B17/10 ,  G08B17/107 ,  G08B29/04 ,  G08B29/24

CPC分类号： G08B29/043 ,  G08B17/107 ,  G08B17/113 ,  G08B29/24

摘要： A smoke detector is disclosed having a radiation source operated in a pulsed mode. Externally of a direct radiation region of the radiation source there is arranged a radiation receiver which, in the presence of smoke or other particles emanating from a combustion process and located in the radiation region, is impinged by scattered radiation and delivers an output signal to an evaluation circuit. The evaluation circuit contains switching elements which, when the number of source output signals or pulses exceeds a predetermined threshold value for the number of source output pulses, delivers an alarm signal. Near to the radiation receiver there is arranged a reference cell in the direct radiation beam of the radiation source, this reference cell controlling the emission of radiation by the radiation source. Further, there is provided circuitry which, in the presence of a slow change in the amplitude of the receiver output pulse, adjusts an amplitude threshold value set for the amplitude of the receiver output pulse at a rate corresponding to a time-constant of more than one minute. Consequently, there is obtained an output signal of the radiation receiver which is dependent upon the smoke density and which is independent of the contamination or soiling of the smoke detector.

摘要翻译： 公开了一种具有以脉冲模式操作的辐射源的烟雾探测器。 在辐射源的直接辐射区域外部布置有辐射接收器，其在存在来自燃烧过程并位于辐射区域中的烟雾或其它颗粒的情况下，被散射辐射撞击并将输出信号传递到 评估电路。 评估电路包含开关元件，当源极输出信号或脉冲的数量超过源极输出脉冲数量的预定阈值时，传递报警信号。 在辐射接收器附近，在辐射源的直接辐射束中布置参考单元，该参考单元控制辐射源的辐射发射。 此外，提供的电路在接收机输出脉冲的振幅的缓慢变化的存在下，以对应于大于等于的时间常数的速率调整为接收器输出脉冲的振幅设定的振幅阈值 等一下。 因此，获得了取决于烟雾密度并且与烟雾探测器的污染或污染无关的辐射接收器的输出信号。

公开(公告)号：US20110233129A1

公开(公告)日：2011-09-29

申请号：US13046824

申请日：2011-03-14

申请人： Zoltan Horvath ,  Gabor Nyiro

发明人： Zoltan Horvath ,  Gabor Nyiro

IPC分类号： B01D35/14 ,  B01D35/02 ,  F02M37/22

CPC分类号： B01D35/1475 ,  B01D29/21 ,  B01D2201/50 ,  F02M37/50

摘要： A fuel filter for motor vehicle, with a filter housing, a fuel inlet and a fuel outlet formed in the housing, as well as a cylindrical filter element arranged in the filter housing, and in a given case with terminal elements closing the ends of the filter element in a way enabling flow of the fuel, where a tubular antistatic insert is electrically connected by the internal surface of the folded paper filter element to the body potential of the vehicle as a grounding element, such that the configuration and installation of the filter element of the fuel filter is not affected.

摘要翻译： 一种用于机动车辆的燃料过滤器，其具有过滤器壳体，形成在壳体中的燃料入口和燃料出口，以及布置在过滤器壳体中的圆柱形过滤器元件，并且在给定情况下，终端元件封闭 过滤元件以使得燃料流动的方式，其中管状抗静电插入件通过折叠纸过滤元件的内表面与车辆的车身电位电连接为接地元件，使得过滤器的配置和安装 燃油过滤器的元件不受影响。

公开(公告)号：US20080073818A1

公开(公告)日：2008-03-27

申请号：US11661807

申请日：2005-09-22

申请人： Antal Pelcz ,  Tamas Illes ,  Zoltan Horvath ,  Laszlo Simon

发明人： Antal Pelcz ,  Tamas Illes ,  Zoltan Horvath ,  Laszlo Simon

IPC分类号： B29C47/88

CPC分类号： B29C48/913 ,  B29C48/10 ,  B29C48/9125

摘要： An apparatus includes an internal and/or an external multiple-stage cooling device arranged coaxially with a drawing orifice of an extruder die and having multilevel tangential outlets for the coolant to stabilize a non-stabilized section of an expanded foil hose by spiral coolant streams. The internal device includes cooling units arranged at axial distances from each other, surrounding the foil section through a gap. Each cooling unit is connected to a coolant supply of selectively adjustable temperature. The external cooling device includes at least two cooling units arranged at an axial distance from each other, surrounding the foil section through a gap. Each cooling unit is provided with tangential inlets and is connected to a coolant supply to supply the coolant of selectively and individually adjustable temperature and/or volume and/or pressure.

摘要翻译： 一种装置包括内部和/或外部多级冷却装置，其与挤出机模头的拉伸孔同轴设置，并具有用于冷却剂的多层切向出口，以通过螺旋形冷却剂流稳定膨胀箔软管的非稳定部分。 内部装置包括彼此轴向间隔布置的冷却单元，通过间隙包围箔片部分。 每个冷却单元连接到可选择性调节温度的冷却剂供应。 外部冷却装置包括至少两个以彼此轴向间隔布置的冷却单元，通过间隙围绕箔片部分。 每个冷却单元设置有切向入口，并且连接到冷却剂供应源，以供选择性地和单独地调节温度和/或体积和/或压力的冷却剂。

公开(公告)号：US4641834A

公开(公告)日：1987-02-10

申请号：US721520

申请日：1985-04-09

申请人： Laszlo Hegedus ,  Zoltan Horvath

发明人： Laszlo Hegedus ,  Zoltan Horvath

IPC分类号： A63B23/04 ,  A63B69/00 ,  A63B67/00

CPC分类号： A63B69/0091 ,  A63B69/002

摘要： The subject of the invention is an apparatus set up on a small area and at any place, thus in the home too, which is suitable for the development of both leg muscles and for the intensification of the kicking force. The apparatus consists of a ball-holding basket capable to move in the direction of kicking and upon completion of the kicking to return it quickly to its initial position. The apparatus may include such adjusting unit, whereby the load applied to the leg is controllable. The apparatus can be set up on the ground or fixed to a wall.

摘要翻译： 本发明的主题是设置在小区域和任何地方，因此在家庭中的装置，其适合于发展双腿肌肉和强化踢力。 该装置包括一个能够沿着踢球方向移动并且完成踢球的球保持篮将其快速返回到其初始位置。 该装置可以包括这样的调节单元，由此施加到腿的负载是可控的。 该设备可以设置在地面上或固定在墙壁上。

公开(公告)号：US20050183779A1

公开(公告)日：2005-08-25

申请号：US11046177

申请日：2005-01-28

申请人： Zoltan Horvath ,  Pal Biegelbauer ,  Tamas Vitalis ,  Karoly Balazs ,  Mihaly Soos ,  Viktor Nyeste ,  Zsolt Kariko

发明人： Zoltan Horvath ,  Pal Biegelbauer ,  Tamas Vitalis ,  Karoly Balazs ,  Mihaly Soos ,  Viktor Nyeste ,  Zsolt Kariko

IPC分类号： B60K15/035 ,  B65D88/64 ,  F02M37/04 ,  F02M37/10 ,  F02M37/20 ,  F02M37/22

CPC分类号： F02M37/20 ,  B60K15/03504 ,  B60K2015/03557 ,  F02M37/103 ,  F02M37/22 ,  Y10T137/86035

摘要： A fuel delivery module assembly for a vehicle which includes a fuel delivery module for supplying fuel from a fuel tank, a flange for attachment to a fuel tank and an emissions canister for controlling evaporative emissions. The fuel delivery module includes a reservoir for retaining fuel and a fuel pump for supplying fuel from the reservoir. The emissions canister is coupled to the fuel delivery module in a sliding relationship and is arranged such that the emissions canister can be displaced along a slide axis relative to the fuel delivery module between an installed position, in which the reservoir and emissions canister overlap parallel with the slide axis, and an installation position, in which the reservoir and emissions canister substantially do not overlap parallel with the slide axis. The invention also provides a fuel tank assembly comprising such a fuel delivery module assembly and to a method of positioning such a fuel delivery module assembly within a fuel tank.

摘要翻译： 一种用于车辆的燃料输送模块组件，其包括用于从燃料箱供应燃料的燃料输送模块，用于附接到燃料箱的凸缘和用于控制蒸发排放的排放罐。 燃料输送模块包括用于保持燃料的储存器和用于从储存器供应燃料的燃料泵。 排放罐以滑动关系耦合到燃料输送模块并且布置成使得排放罐可以在安装位置之间相对于燃料输送模块沿着滑动轴线移位，在该位置之间，储存器和排放罐重叠与 滑动轴线和安装位置，其中储存器和排放罐基本上不与滑动轴线平行重叠。 本发明还提供了一种燃料箱组件，其包括这种燃料输送模块组件和将这种燃料输送模块组件定位在燃料箱内的方法。

公开(公告)号：US4181439A

公开(公告)日：1980-01-01

申请号：US777397

申请日：1977-03-14

申请人： Erwin Tresch ,  Zoltan Horvath

发明人： Erwin Tresch ,  Zoltan Horvath

IPC分类号： G01N21/53 ,  G08B17/107 ,  G01N21/00

CPC分类号： G08B17/107 ,  G08B17/113

摘要： An optical smoke detector comprising a radiation source which transmits radiation into a predetermined spatial region and a radiation receiver to which there is delivered the radiation which is scattered by particles located along the radiation path. The radiation source possesses a substantially conical ring-shaped radiation characteristic or pattern and the radiation receiver is arranged substantially at or along the cone axis.

摘要翻译： 一种光学烟雾探测器，其包括将辐射传输到预定空间区域中的辐射源和辐射接收器，在该辐射接收器处传送由沿着辐射路径定位的颗粒散射的辐射。 辐射源具有基本上圆锥形的环形辐射特征或图案，并且辐射接收器基本上布置在锥轴或沿着锥轴。

公开(公告)号：US4175865A

公开(公告)日：1979-11-27

申请号：US777396

申请日：1977-03-14

申请人： Zoltan Horvath ,  Erwin Tresch

发明人： Zoltan Horvath ,  Erwin Tresch

IPC分类号： G01N21/53 ,  G08B17/10 ,  G08B17/107 ,  G01N21/26

CPC分类号： G08B17/107 ,  G08B17/113

摘要： An optical smoke detector comprising a radiation source transmitting radiation throughout a predetermined spatial region and at least one radiation receiver to which there is delivered the radiation scattered by particles located in the radiation region. One or a number of elements conducting radiation by reflection are provided and arranged such that they remove radiation, which has been forwardly scattered at an acute angle with respect to the radiation direction, at a substantially ring-shaped zone about the region of direct radiation and delivers such removed forwardly scattered radiation to the radiation receiver.

摘要翻译： 一种光学烟雾探测器，其包括在整个预定空间区域中传播辐射的辐射源和至少一个辐射接收器，在该辐射接收器处传送由位于辐射区域中的颗粒散射的辐射。 提供和布置一个或多个通过反射进行辐射的元件，并且布置成使得它们以围绕直接辐射区域的大致环形区域去除已经相对于辐射方向以锐角向前散射的辐射，并且 将这种去除的向前散射的辐射传送到辐射接收器。