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1.发明授权Antibodies to aggrecan-degrading metalloprotease and diagnostic methods using same 有权抗凝集素降解金属蛋白酶的抗体及其使用的诊断方法公开(公告)号：US07049412B1
公开(公告)日：2006-05-23
申请号：US09634287
申请日：2000-08-09
申请人： Elizabeth C. Arner , Timothy C. Burn , Robert A. Copeland , Carl P. Decicco , Ruiqin Liu , Ronald Magolda , Michael Pratta , Kimberly A. Solomon , Micky D. Tortorella , James M. Trzaskos , Fude Yang
发明人： Elizabeth C. Arner , Timothy C. Burn , Robert A. Copeland , Carl P. Decicco , Ruiqin Liu , Ronald Magolda , Michael Pratta , Kimberly A. Solomon , Micky D. Tortorella , James M. Trzaskos , Fude Yang
IPC分类号： C07K16/00
CPC分类号： C12N9/6489 , A61K38/00 , C07K16/40 , C12Q1/37 , G01N33/6887 , G01N2333/96486 , G01N2500/00 , G01N2800/102
摘要： The invention is directed to the family of aggrecan degrading metallo proteases (ADMPs) that exhibit the ability to cleave the aggrecan core protein between amino acid residues Glu373-Ala374. The invention encompasses the nucleic acids encoding such enzymes, processes for production of recombinant ADMPs, compositions containing such enzymes, and the use of these enzymes in various assays and for the development of novel inhibitors for use as therapies for diseases involving aggrecanase-mediated degradation of cartilage or other aggrecanase-associated diseases.
摘要翻译： 本发明涉及聚集蛋白聚糖降解性金属蛋白酶（ADMP）的家族，其表现出在聚集蛋白聚糖核心蛋白之间切割氨基酸残基Glu 373之间的能力。 本发明包括编码这些酶的核酸，重组ADMP的生产方法，含有这些酶的组合物，以及这些酶在各种测定中的用途以及用于开发用于治疗涉及聚蛋白聚糖蛋白聚糖酶介导的降解的疾病的新型抑制剂 软骨或其他聚集蛋白聚糖相关疾病。
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![5-[3-(4-Benzyloxyphenylthio)-fur-2-yl]-imidazolidin-2, 4-dione and analogues as inhibitors of macrophage elastase](/abs-image/US/2006/02/23/US20060041000A1/abs.jpg.150x150.jpg)
2.发明申请5-[3-(4-Benzyloxyphenylthio)-fur-2-yl]-imidazolidin-2, 4-dione and analogues as inhibitors of macrophage elastase 有权5- [3-（4-苄氧基苯硫基） - 呋喃-2-基] - 咪唑烷-2,4-二酮及类似物作为巨噬细胞弹性蛋白酶抑制剂公开(公告)号：US20060041000A1
公开(公告)日：2006-02-23
申请号：US11205954
申请日：2005-08-17
申请人： Fude Yang
发明人： Fude Yang
IPC分类号： A61K31/4178 , C07D405/04
CPC分类号： C07D405/04
摘要： 5-[3-(4-benzyloxyphenylthio)-fur-2-yl]-imidazolidin-2,4-dione and analogues useful as inhibitors of macrophage elastase are disclosed.
摘要翻译： 公开了可用作巨噬细胞弹性蛋白酶抑制剂的5- [3-（4-苄氧基苯硫基） - 呋喃-2-基] - 咪唑烷-2,4-二酮和类似物。
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![5-[3-(4-benzyloxyphenylthio)-fur-2-yl]-imidazolidin-2, 4-dione and analogues as inhibitors of macrophage elastase](/abs-image/US/2007/02/20/US07179831B2/abs.jpg.150x150.jpg)
3.发明授权5-[3-(4-benzyloxyphenylthio)-fur-2-yl]-imidazolidin-2, 4-dione and analogues as inhibitors of macrophage elastase 有权5- [3-（4-苄氧基苯硫基） - 呋喃-2-基] - 咪唑烷-2,4-二酮及类似物作为巨噬细胞弹性蛋白酶抑制剂公开(公告)号：US07179831B2
公开(公告)日：2007-02-20
申请号：US11205954
申请日：2005-08-17
申请人： Fude Yang
发明人： Fude Yang
IPC分类号： A61K31/4166 , C07D403/04
CPC分类号： C07D405/04
摘要： 5-[3-(4-benzyloxyphenylthio)-fur-2-yl]-imidazolidin-2,4-dione and analogues useful as inhibitors of macrophage elastase are disclosed.
摘要翻译： 公开了可用作巨噬细胞弹性蛋白酶抑制剂的5- [3-（4-苄氧基苯硫基） - 呋喃-2-基] - 咪唑烷-2,4-二酮和类似物。
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4.发明授权Methods of identifying compounds that inhibit DNA synthesis in mycobacterium tuberculosis and compositions, reagents and kits for performing the same 失效识别在结核分枝杆菌中抑制DNA合成的化合物的方法及其组合物，试剂和用于进行结核分枝杆菌的试剂盒的方法
公开(公告)号：US5834279A
公开(公告)日：1998-11-10
申请号：US813940
申请日：1997-03-03
申请人： Harvey Rubin , Fude Yang , David Avarbock , Sean Curran
发明人： Harvey Rubin , Fude Yang , David Avarbock , Sean Curran
CPC分类号： C12N9/0093 , C12N9/90 , C12Y117/04001 , C12Y599/01002 , A01K2217/05
摘要： Nucleic acid molecules that encode R2 subunit protein and topoisomerase I protein, fragments thereof, recombinant expression vectors and host cells are disclosed. Oligonucleotide molecules with nucleotide sequences complimentary to a nucleotide sequence encode R2 subunit protein and topoisomerase I protein are disclosed.
摘要翻译： 公开了编码R2亚基蛋白和拓扑异构酶I蛋白的核酸分子，其片段，重组表达载体和宿主细胞。 公开了具有与编码R2亚单位蛋白质和拓扑异构酶I蛋白质的核苷酸序列互补的核苷酸序列的寡核苷酸分子。
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公开(公告)号：US06753176B2
公开(公告)日：2004-06-22
申请号：US10247685
申请日：2002-09-19
申请人： Elizabeth C. Arner , Timothy C. Burn , Robert A. Copeland , Carl P. Decicco , Ruiqin Liu , Ronald Magolda , Michael Pratta , Kimberly A. Solomon , Micky D. Tortorella , James M. Trzaskos , Fude Yang
发明人： Elizabeth C. Arner , Timothy C. Burn , Robert A. Copeland , Carl P. Decicco , Ruiqin Liu , Ronald Magolda , Michael Pratta , Kimberly A. Solomon , Micky D. Tortorella , James M. Trzaskos , Fude Yang
IPC分类号： C12N964
CPC分类号： C12N9/6489 , A61K38/00 , C07K16/40 , C12Q1/37 , G01N33/6887 , G01N2333/96486 , G01N2500/00 , G01N2800/102
摘要： The invention is directed to the family of aggrecan degrading metallo proteases (ADMPs) that exhibit the ability to cleave the aggrecan core protein between amino acid residues Glu373-Ala374. The invention encompasses the nucleic acids encoding such enzymes, processes for production of recombinant ADMPs, compositions containing such enzymes, and the use of these enzymes in various assays and for the development of novel inhibitors for use as therapies for diseases involving aggrecanase-mediated degradation of cartilage or other aggrecanase-associated diseases.
摘要翻译： 本发明涉及聚集蛋白聚糖降解金属蛋白酶（ADMP）家族，其表现出在氨基酸残基Glu <373> -Ala <374>之间切割聚蛋白聚糖核心蛋白的能力。 本发明包括编码这些酶的核酸，重组ADMP的生产方法，含有这些酶的组合物，以及这些酶在各种测定中的用途以及用于开发用于治疗涉及聚蛋白聚糖蛋白聚糖酶介导的降解的疾病的新型抑制剂 软骨或其他聚集蛋白聚糖相关疾病。
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公开(公告)号：US06521436B1
公开(公告)日：2003-02-18
申请号：US09634286
申请日：2000-08-09
申请人： Elizabeth C. Arner , Timothy C. Burn , Robert A. Copeland , Carl P. Decicco , Ruiqin Liu , Ronald Magolda , Michael Pratta , Kimberly A. Solomon , Micky D. Tortorella , James M. Trzaskos , Fude Yang
发明人： Elizabeth C. Arner , Timothy C. Burn , Robert A. Copeland , Carl P. Decicco , Ruiqin Liu , Ronald Magolda , Michael Pratta , Kimberly A. Solomon , Micky D. Tortorella , James M. Trzaskos , Fude Yang
IPC分类号： C12N964
CPC分类号： C12N9/6489 , A61K38/00 , C07K16/40 , C12Q1/37 , G01N33/6887 , G01N2333/96486 , G01N2500/00 , G01N2800/102
摘要： The invention is directed to the family of aggrecan degrading metallo proteases (ADMPs) that exhibit the ability to cleave the aggrecan core protein between amino acid residues Glu373-Ala374. The invention encompasses the nucleic acids encoding such enzymes, processes for production of recombinant ADMPs, compositions containing such enzymes, and the use of these enzymes in various assays and for the development of novel inhibitors for use as therapies for diseases involving aggrecanase-mediated degradation of cartilage or other aggrecanase-associated diseases.
摘要翻译： 本发明涉及聚集蛋白聚糖降解金属蛋白酶（ADMP）家族，其表现出在氨基酸残基Glu373-Ala374之间切割聚蛋白聚糖核心蛋白的能力。 本发明包括编码这种酶的核酸，重组ADMP的生产方法，含有这些酶的组合物，以及这些酶在各种测定中的用途以及用于开发用于治疗涉及聚蛋白聚糖蛋白聚糖酶介导的降解的疾病的新型抑制剂 软骨或其他聚集蛋白聚糖相关疾病。
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公开(公告)号：US06451575B1
公开(公告)日：2002-09-17
申请号：US09122126
申请日：1998-07-24
申请人： Elizabeth C. Arner , Timothy C. Burn , Robert A. Copeland , Carl P. Decicco , Ruiqin Liu , Ronald Magolda , Michael Pratta , Kimberly A. Solomon , Micky D. Tortorella , James M. Trzaskos , Fude Yang
发明人： Elizabeth C. Arner , Timothy C. Burn , Robert A. Copeland , Carl P. Decicco , Ruiqin Liu , Ronald Magolda , Michael Pratta , Kimberly A. Solomon , Micky D. Tortorella , James M. Trzaskos , Fude Yang
IPC分类号： C12N964
CPC分类号： C12N9/6489 , A61K38/00 , C07K16/40 , C12Q1/37 , G01N33/6887 , G01N2333/96486 , G01N2500/00 , G01N2800/102
摘要： The invention is directed to the family of aggrecan degrading metallo proteases (ADMPs) that exhibit the ability to cleave the aggrecan core protein between amino acid residues Glu373-Ala374. The invention encompasses the nucleic acids encoding such enzymes, processes for production of recombinant ADMPs, compositions containing such enzymes, and the use of these enzymes in various assays and for the development of novel inhibitors for use as therapies for diseases involving aggrecanase-mediated degradation of cartilage or other aggrecanase-associated diseases.
摘要翻译： 本发明涉及聚集蛋白聚糖降解金属蛋白酶（ADMP）家族，其表现出在氨基酸残基Glu373-Ala374之间切割聚蛋白聚糖核心蛋白的能力。 本发明包括编码这些酶的核酸，重组ADMP的生产方法，含有这些酶的组合物，以及这些酶在各种测定中的用途以及用于开发用于治疗涉及聚蛋白聚糖蛋白聚糖酶介导的降解的疾病的新型抑制剂 软骨或其他聚集蛋白聚糖相关疾病。
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