公开(公告)号：US08512752B2

公开(公告)日：2013-08-20

申请号：US12440721

申请日：2007-09-05

申请人： Di Meo Chiara ,  Devis Galesso ,  Ada Mascolo ,  Fabiana Crescenzi ,  Alberta Crescenzi ,  Flavia Crescenzi ,  Fulvia Crescenzi ,  Laura Crescenzi ,  Vittoria Crescenzi

发明人： Vittorio Crescenzi ,  Di Meo Chiara ,  Devis Galesso

IPC分类号： A61K31/728 ,  A61K31/738 ,  A01N43/04

CPC分类号： A61L27/52 ,  A61K9/0014 ,  A61K9/06 ,  A61K47/36 ,  A61L27/20 ,  C08B37/0072 ,  C08L5/08

摘要： Crosslinked derivatives of polycarboxylated polysaccharides are described, wherein at least one of the polysaccharide chains consists of hyaluronic acid or a derivative thereof, crosslinked by means of reactions of the “click chemistry” type and their use in the field of viscosupplementation, plastic surgery, oncologic and reconstructive surgery and also as matrices for controlled release systems of biologically and/or pharmacologically active molecules and/or macromolecules.

摘要翻译： 描述了多羧化多糖的交联衍生物，其中至少一个多糖链由透明质酸或其衍生物组成，通过“点击化学”类型的反应及其在粘弹性补充领域，整形外科，肿瘤学中的应用而交联 和重建手术，还可以作为生物和/或药理学活性分子和/或大分子的控制释放系统的基质。