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    THERAPEUTIC METHODS AND COMPOSITIONS INVOLVING ISOFLAVONES
    1.
    发明申请
    THERAPEUTIC METHODS AND COMPOSITIONS INVOLVING ISOFLAVONES 审中-公开
    涉及ISOFLAVONES的治疗方法和组合物

    公开(公告)号：US20110212989A1

    公开(公告)日：2011-09-01

    申请号：US13102805

    申请日：2011-05-06

    Applicant: Graham Edmund KELLY ,  George Eustace Joannou

    Inventor： Graham Edmund KELLY ,  George Eustace Joannou

    IPC: A61K31/4375 ,  A61P35/00 ,  A61P19/10 ,  A61P25/24 ,  A61P25/22 ,  A61P25/06 ,  A61P9/10 ,  A61P25/28 ,  A61P17/14 ,  A61P19/02 ,  A61P9/12 ,  A61P35/02 ,  A61K31/352 ,  C07D311/36 ,  C12N1/00 ,  A61K31/12 ,  C07C49/83 ,  C07D471/16 ,  C07D209/10 ,  A61K31/404 ,  C07D215/04 ,  A61K31/47

    CPC classification number: A61K8/498 ,  A61K8/35 ,  A61K8/492 ,  A61K31/12 ,  A61K31/352 ,  A61K31/353 ,  A61K31/355 ,  A61K31/40 ,  A61K31/404 ,  A61K31/405 ,  A61K31/47 ,  A61K31/4745 ,  A61K2800/522 ,  A61Q7/00 ,  A61Q19/00 ,  A61Q19/08 ,  C07C45/46 ,  C07C45/673 ,  C12P7/26 ,  C12P17/04 ,  C12P17/10 ,  A61K2300/00 ,  C07C49/83 ,  C07C49/84

    Abstract: Therapeutic method of treatment, compositions and foodstuffs are described which contain isoflavone compounds described by general formula (I), in which Z is H, R1 is H or RACO wherein Ra is C1-10alkyl or an amino acid, R2 is H, OH or ORB where RB is an amino acid, or CORA where RA is as previously defined, W is H, A is H or OH, and B is selected from (a), (b), (c) or W is H, and A and B taken together form a six-membered ring selected from (d), or W, A and B taken with the groups with which they are associated comprise (f) and B is (g) where R3 is H, CORA where RA is as previously defined, CO2RC where RC is C1-10alkyl, or CORB where RB is as previously defined, R4 is H, CORD where RD is H, OH, C1-10alkyl or an amino acid, CO2RC where RC is as previously defined, CORE where RE is H, C1-10alkyl or an amino acid, COOH, CORC where RC is as previously defined, or CONHRE where RE is as previously defined, R5 is H, CO2RC where RC is as previously defined, or CORCORE where RC and RE are as previously defined, and where the two R5 groups are attached to the same group they are the same or different, R6 is H or hydroxyl C1-10alkyl, X is preferably O, but may be N or S, and Y is (h) where R7 is H, or C1-10alkyl.

    Abstract translation: 描述了治疗方法，组合物和食品，其含有通式（I）所述的异黄酮化合物，其中Z为H，R 1为H或其中R a为C 1-10烷基或氨基酸，R 2为H，OH或 ORB，其中RB是氨基酸，或其中RA如前所定义的CORA，W是H，A是H或OH，B选自（a），（b），（c）或W是H，A 和B一起形成选自（d）或W，A和B的六元环，与它们所关联的基团一起使用，包括（f）和B是（g）其中R3是H，CORA，其中RA是 如前所定义，其中RC是C 1-10烷基的CO 2 C或其中R B如前所定义的CORB，R 4是H，CORD，其中R D是H，OH，C 1-10烷基或氨基酸，CO 2 R C，其中RC如前所定义，CORE 其中RE是H，C 1-10烷基或氨基酸，COOH，CORC，其中RC如前所定义，或CONHRE，其中RE如前所定义，R 5是H，CO 2 CRC，其中RC如前所定义，或CORCORE，其中RC和RE 作为公关 并且其中两个R 5基团连接在同一基团上时，它们相同或不同，R 6为H或羟基C 1-10烷基，X优选为O，但可为N或S，且Y为（h）其中 R7是H或C1-10烷基。

    METHODS OF CHOLESTEROL REDUCTION USING ISOFLAVONES
    8.
    发明申请
    METHODS OF CHOLESTEROL REDUCTION USING ISOFLAVONES 审中-公开
    使用ISOFLAVONES减少胆固醇的方法

    公开(公告)号：US20110305782A1

    公开(公告)日：2011-12-15

    申请号：US13163012

    申请日：2011-06-17

    Applicant: Graham Edmund Kelly

    Inventor： Graham Edmund Kelly

    IPC: A61K36/48 ,  A61P7/00 ,  A61K31/352

    CPC classification number: A61K31/35 ,  A23L11/05 ,  A23L11/07 ,  A23L33/11 ,  A61K31/353 ,  A61K31/7048 ,  A61K36/185 ,  A61K36/48 ,  A61K38/08 ,  A61K2300/00

    Abstract: This invention relates to natural products containing phyto-oestrogens, or phyto-oestrogen analogues, which have various beneficial physiological effects in man, and which have a variety of uses, such as to promote good health and as a dietary additive, for example. The invention describes a method of improving the health of a human by administering to the human a health supplementing amount of a phyto-oestrogen selected from genistein, daidzein formononentin and/or biochanin A. A health supplement comprising a health supplementary amount of a phyto-oestrogen selected from genisten daidzein formononentin and/or biochanin A, is also described. Preferably, the supplement also comprises at least one dietary suitable excipient, diluent, carrier or food, and may be in the form of a tablet or capsule, for example. Ideally, the phyto-oestrogen is extracted from red clover or from soya, although any source rich in isoflavones may also be used. The supplement can be used to prevent or ameliorate such conditions as breast cancer, benign breast disease, pre-menstrual syndrome, or symptoms associated with menopause in women, or various types of cancer, and especially for high blood cholesterol levels in all humans, for instance.

    Abstract translation: 本发明涉及含有植物雌激素或植物雌激素类似物的天然产物，其在人体中具有各种有益的生理作用，并且具有多种用途，例如促进良好的健康和作为饮食添加剂。 本发明描述了一种通过向人类施用健康补充量的选自染料木黄酮，黄豆苷元和/或鹰嘴豆素A的植物雌激素来改善人体健康的方法。一种健康补充剂，其包含健康补充量的植物 - 还描述了选自染料木黄酮大豆黄酮和/或鹰嘴豆素A的雌激素。 优选地，补充剂还包含至少一种膳食适合的赋形剂，稀释剂，载体或食物，并且可以是例如片剂或胶囊的形式。 理想地，植物雌激素是从红三叶草或大豆提取的，尽管也可以使用富含异黄酮的任何来源。 该补充剂可用于预防或改善诸如乳腺癌，良性乳腺疾病，月经前综合征或与妇女更年期相关的症状或各种类型的癌症，特别是所有人类的高血胆固醇水平的病症， 实例。

    Therapeutic uses of glucan
    10.
    发明授权
    Therapeutic uses of glucan 失效
    葡聚糖的治疗用途

    公开(公告)号：US07622575B2

    公开(公告)日：2009-11-24

    申请号：US11499534

    申请日：2006-08-04

    Applicant: Graham Edmund Kelly

    Inventor： Graham Edmund Kelly

    IPC: A61K31/715

    CPC classification number: A61Q17/04 ,  A61K8/73 ,  A61K31/716 ,  A61L26/0023 ,  A61Q19/004 ,  A61Q19/08 ,  C08B37/0024 ,  C12P19/04 ,  Y10S514/925 ,  Y10S514/928 ,  C08L5/00

    Abstract: The present invention is directed to methods of using glucan compositions, comprising water insoluble microparticulate glucans, in the treatment of connective tissue injuries. The water insoluble microparticulate glucans used in the compositions comprise branched β-(1,3)(1,6) glucan. The glucan compositions used in the present invention are essentially free of unbranched β-(1,3)(1,6) glucan and non-glucan components.

    Abstract translation: 本发明涉及使用包含水不溶性微粒葡聚糖的葡聚糖组合物在治疗结缔组织损伤中的方法。 组合物中使用的水不溶性微粒葡聚糖包含支链β-（1,3）（1,6）葡聚糖。 用于本发明的葡聚糖组合物基本上不含无支化的β-（1,3）（1,6）葡聚糖和非葡聚糖组分。

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