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    MAGNETIC BEAD AGGREGATION ASSAY SYSTEM
    2.
    发明申请
    MAGNETIC BEAD AGGREGATION ASSAY SYSTEM 审中-公开
    磁珠聚集测定系统

    公开(公告)号：US20140227679A1

    公开(公告)日：2014-08-14

    申请号：US14131328

    申请日：2012-07-09

    申请人： Gil Lee ,  Peng Li ,  Mark Platt ,  Gemma Cannon

    发明人： Gil Lee ,  Peng Li ,  Mark Platt ,  Gemma Cannon

    IPC分类号： G01N33/50

    CPC分类号： G01N33/54326 ,  B03C1/01 ,  B03C1/288 ,  B03C2201/18 ,  B03C2201/24 ,  B03C2201/26 ,  G01N2446/84

    摘要： There is provided a method of aggregating a plurality of beads in a magnetic bead aggregation assay for subsequent analysis comprising: —providing magnetic beads comprising a capture probe for binding with said target analyte; —reacting the magnetic beads with the sample including a target analyte in a reaction chamber aggregating the magnetic beads in the presence of a magnetic field with the target analyte to allow formation of magnetic bead aggregates having physical properties detectable to enable characterisation of the aggregates on an aggregate by aggregate basis using a detector to measure the physical properties of the aggregates. Further provided are a method and system for detecting analytes in a sample by characterising the magnetic bead aggregates on an aggregate by aggregate basis by measuring physical properties of the aggregates.

    摘要翻译： 提供了一种在用于随后分析的磁珠聚集测定中聚集多个珠的方法，包括： - 提供包含用于与所述目标分析物结合的捕获探针的磁珠; 在包含目标分析物的反应室中，在存在磁场的情况下将目标分析物与目标分析物一起反应，以使形成具有可检测物理特性的磁珠聚集体，以使得能够在 使用检测器以聚集为基础的聚集体来测量聚集体的物理性质。 进一步提供了一种通过测量聚集体的物理性质通过聚集体来表征聚集体上的磁珠聚集体来检测样品中的分析物的方法和系统。

    NON-LINEAR MAGNETOPHORETIC SEPARATION DEVICE, SYSTEM AND METHOD
    3.
    发明申请
    NON-LINEAR MAGNETOPHORETIC SEPARATION DEVICE, SYSTEM AND METHOD 有权
    非线性磁分离装置，系统和方法

    公开(公告)号：US20140021105A1

    公开(公告)日：2014-01-23

    申请号：US13809091

    申请日：2011-07-07

    申请人： Gil Lee ,  Peng Li ,  Mark Platt ,  Gemma Cannon

    发明人： Gil Lee ,  Peng Li ,  Mark Platt ,  Gemma Cannon

    IPC分类号： B03C1/02

    CPC分类号： B03C1/02 ,  B03C1/032 ,  B03C1/24 ,  B03C1/288 ,  B03C2201/18 ,  B03C2201/24 ,  B03C2201/26 ,  G01N27/44756

    摘要： A flow enhanced method and system for flow non-linear magnetophoresis (F-NLM) is described. By tuning an external field frequency and the flow rate the migration velocities of different bead types may be caused to differ by several orders of magnitude over an extended range of frequencies to allow for separation of particles. Use of such efficiency in separation in bio-separation and similar assays is described.

    摘要翻译： 描述了用于流动非线性磁电泳（F-NLM）的流动增强方法和系统。 通过调整外场频率和流速，可以使不同珠粒类型的迁移速度在扩展的频率范围内相差几个数量级以允许分离颗粒。 描述了在生物分离中的这种效率的使用和类似的测定。

    Magnetic bead aggregation assay system
    4.
    发明授权
    Magnetic bead aggregation assay system 有权

    公开(公告)号：US10386364B2

    公开(公告)日：2019-08-20

    申请号：US14131328

    申请日：2012-07-09

    申请人： Gil Lee ,  Peng Li ,  Mark Platt ,  Gemma Cannon

    发明人： Gil Lee ,  Peng Li ,  Mark Platt ,  Gemma Cannon

    IPC分类号： G01N33/50 ,  G01N33/543 ,  B03C1/01 ,  B03C1/28

    摘要： There is provided a method of aggregating a plurality of beads in a magnetic bead aggregation assay for subsequent analysis comprising: —providing magnetic beads comprising a capture probe for binding with said target analyte; —reacting the magnetic beads with the sample including a target analyte in a reaction chamber aggregating the magnetic beads in the presence of a magnetic field with the target analyte to allow formation of magnetic bead aggregates having physical properties detectable to enable characterization of the aggregates on an aggregate by aggregate basis using a detector to measure the physical properties of the aggregates. Further provided are a method and system for detecting analytes in a sample by characterizing the magnetic bead aggregates on an aggregate by aggregate basis by measuring physical properties of the aggregates.