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公开(公告)号：US5336164A
公开(公告)日：1994-08-09
申请号：US817173
申请日：1992-01-06
申请人： Michael T. Snider , Kane M. High , Georg Panol , James Ultman , Russell B. Richard , John K. Stene , Garfield B. Russell
发明人： Michael T. Snider , Kane M. High , Georg Panol , James Ultman , Russell B. Richard , John K. Stene , Garfield B. Russell
CPC分类号： A61M1/1678 , A61M1/1698 , Y10S128/03
摘要： An intravascular membrane lung is adapted for percutaneous venous insertion into a living body and comprises an elongated multi lumen catheter and elongated gas exchange members in the form of a large number of microporous fibers tethered at one end to the catheter and extending away from the catheter in all directions. The microporous fibers are in communication with the lumina of the catheter which includes one conduit for delivery of 100% oxygen to the fibers and another conduit for flushing away carbon dioxide from the fibers. The catheter extends between a proximal end and a distal end being a leading end for insertion into the body. The distal end includes a selectively inflatable balloon having an enlarged size larger than a nominal transverse dimension of said catheter and smaller than the inner nominal dimensions of any of the body cavities into which it extends. Upon insertion into the femoral vein, the blood flowing back to the natural lungs of the body propel the catheter and its attached microporous fibers through the inferior vena cava, then into and through the right ventricle, then into and through the pulmonary artery. Another lumen of the catheter serves to receive a fiberoptic bundle to monitor oxygenation of the blood which has passed over the device and still another lumen is provided for sampling blood at the tip of the catheter.
摘要翻译： 血管内膜肺适于经皮静脉插入生物体，并且包括细长的多腔导管和细长的气体交换构件，其形式为大量微孔纤维的形式，一端连接到导管并远离导管延伸 八方。 微孔纤维与导管的导管连通，其包括一个用于将100％的氧输送到纤维的导管和用于从纤维冲洗掉二氧化碳的另一导管。 导管在近端和远端之间延伸，作为插入身体的前端。 远端包括具有大于所述导管的标称横向尺寸的放大尺寸并且小于其延伸的任何体腔的内标称尺寸的选择性可充气球囊。 在插入股静脉时，流回身体的天然肺部的血液将导管及其附着的微孔纤维推动通过下腔静脉，然后穿过右心室，然后穿过肺动脉。 导管的另一个内腔用于接收纤维束以监测已经通过该装置的血液的氧合，并且还提供另一个内腔，用于对导管末端的血液进行取样。
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公开(公告)号：US4242460A
公开(公告)日：1980-12-30
申请号：US972961
申请日：1978-12-26
CPC分类号： C12M29/10 , A61M1/1627 , A61M1/3472 , A61M1/3475 , A61M1/3489 , C12M23/06 , C12M29/04 , Y10S128/03 , Y10S623/915
摘要： A cell culture device for use, e.g., as an artificial pancreas, featuring, in various aspects, a semipermeable tube wrapped about a spool and mounted within a cylinder to form a cell culture compartment; an inlet and an outlet strand of the semipermeable tube being wrapped to form alternating adjacent coils to provide improved convective transport; and the semipermeable tube being wrapped to form helical coils to provide improved conductive transport.
摘要翻译： 一种用作例如人造胰腺的细胞培养装置，其特征在于，在各个方面，包裹在卷轴周围并安装在圆筒内以形成细胞培养室的半透明管; 半透明管的入口和出口链被包裹以形成交替的相邻线圈，以提供改进的对流运输; 并且所述半透明管被包裹以形成螺旋线圈以提供改进的导电传输。
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公开(公告)号：US5487727A
公开(公告)日：1996-01-30
申请号：US232788
申请日：1994-04-22
申请人： Michael T. Snider , Kane M. High , Georg Panol , James Ultman , Russell B. Richard , John K. Stene , Garfield B. Russell
发明人： Michael T. Snider , Kane M. High , Georg Panol , James Ultman , Russell B. Richard , John K. Stene , Garfield B. Russell
CPC分类号： A61M1/1678 , A61M1/1698 , Y10S128/03
摘要： An intravascular membrane lung is adapted for percutaneous venous insertion into a living body and comprises an elongated multi lumen catheter and elongated gas exchange members in the form of a large number of microporous fibers tethered at one end to the catheter and extending away from the catheter in all directions. The microporous fibers are in communication with the lumina of the catheter which includes one conduit for delivery of 100% oxygen to the fibers and another conduit for flushing away carbon dioxide from the fibers. The catheter extends between a proximal end and a distal end being a leading end for insertion into the body. The distal end includes a selectively inflatable balloon having an enlarged size larger than a nominal transverse dimension of said catheter and smaller than the inner nominal dimensions of any of the body cavities into which it extends. Upon insertion into the femoral vein, the blood flowing back to the natural lungs of the body propel the catheter and its attached microporous fibers through the inferior vena cava, then into and through the right ventricle, then into and through the pulmonary artery. Another lumen of the catheter serves to receive a fiberoptic bundle to monitor oxygenation of the blood which has passed over the device and still another lumen is provided for sampling blood at the tip of the catheter.
摘要翻译： 血管内膜肺适于经皮静脉插入生物体，并且包括细长的多腔导管和细长的气体交换构件，其形式为在一端处连接到导管并远离导管延伸的大量微孔纤维 八方。 微孔纤维与导管的导管连通，其包括一个用于将100％的氧输送到纤维的导管和用于从纤维冲洗掉二氧化碳的另一导管。 导管在近端和远端之间延伸，作为插入身体的前端。 远端包括具有大于所述导管的标称横向尺寸的放大尺寸并且小于其延伸的任何体腔的内标称尺寸的选择性可充气球囊。 在插入股静脉时，流回身体的天然肺部的血液将导管及其附着的微孔纤维推动通过下腔静脉，然后穿过右心室，然后穿过肺动脉。 导管的另一个内腔用于接收纤维束以监测已经通过该装置的血液的氧合，并且还提供另一个内腔，用于对导管末端的血液进行取样。
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公开(公告)号：US4242459A
公开(公告)日：1980-12-30
申请号：US957303
申请日：1978-11-02
CPC分类号： C12M29/04 , A01N1/0263 , A61F2/022 , C12M23/06 , C12M29/10 , Y10S128/03
摘要： A cell culture device for use, e.g., as an artificial pancreas, featuring, in various aspects, a tightly wound spiral tube snugly fit in a cavity to form a cell culture compartment, the spiral being eccentrically offset in the cavity to reduce the volume of the compartment, a sloped passage in the body with an end of the tube extending through the passage to the innermost spiral without bending sharply, the ends of the spiral tube communicating with ports on the same side of the body, and a wall of the cavity facing the spiral and being spaced from the tube to form an end of the compartment to provide for simplified cell loading.
摘要翻译： 用于例如人造胰腺的细胞培养装置，其特征在于在各个方面，紧密缠绕的螺旋管紧密地配合在空腔中以形成细胞培养室，所述螺旋在空腔中偏心偏移以减小体积 隔室，主体中的倾斜通道，管的一端延伸穿过通道至最内螺旋而不会急剧弯曲，螺旋管的端部与本体的同一侧上的端口连通，以及腔的壁 面对螺旋并且与管间隔开以形成隔间的端部以提供简化的电池负载。
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