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    Process for preparing water-soluble phosphonooxymethyl derivatives of alcohol and phenol
    3.
    发明授权
    Process for preparing water-soluble phosphonooxymethyl derivatives of alcohol and phenol 失效
    制备醇和苯酚的水溶性膦酰氧甲基衍生物的方法

    公开(公告)号：US07534776B2

    公开(公告)日：2009-05-19

    申请号：US11586576

    申请日：2006-10-26

    申请人： George Bonneville ,  Greg Delahanty ,  Andrew J. Walz

    发明人： George Bonneville ,  Greg Delahanty ,  Andrew J. Walz

    IPC分类号： A61K31/66

    CPC分类号： C07K7/645 ,  C07F9/091 ,  C07F9/65522 ,  C07F9/6561

    摘要： A process for making water-soluble phosphonooxymethyl ethers of hindered alcohol and phenol containing pharmaceuticals, such as camptothecin, propofol, etoposide, Vitamin E and Cyclosporin A. In particular, the process for preparing water-soluble phosphonooxymethyl derivatives comprises the steps of: R—OH represents an alcohol- or phenol-containing drug, n represents an integer of 1 or 2, R1 is hydrogen, an alkali metal ion, or a pharmaceutically acceptable cation, and R2 is hydrogen, an alkali metal ion, or a pharmaceutically acceptable cation.

    摘要翻译： 一种制备受阻醇和含苯酚的药物，如喜树碱，异丙酚，依托泊苷，维生素E和环孢菌素A的水溶性膦酰氧甲基醚的方法。特别地，制备水溶性膦酰氧甲基衍生物的方法包括以下步骤：R- OH表示含醇或苯酚的药物，n表示1或2的整数，R1表示氢，碱金属离子或药学上可接受的阳离子，R2表示氢，碱金属离子或药学上可接受的阳离子 。

    Process for preparing water soluble phosphonooxymethyl derivatives of alcohol and phenol
    4.
    发明授权
    Process for preparing water soluble phosphonooxymethyl derivatives of alcohol and phenol 有权
    制备醇和苯酚的水溶性膦酰氧甲基衍生物的方法

    公开(公告)号：US07229978B2

    公开(公告)日：2007-06-12

    申请号：US10498013

    申请日：2002-12-20

    申请人： George Bonneville ,  Greg Delahanty ,  Andrew J. Walz

    发明人： George Bonneville ,  Greg Delahanty ,  Andrew J. Walz

    IPC分类号： A61K31/66

    CPC分类号： C07K7/645 ,  C07F9/091 ,  C07F9/65522 ,  C07F9/6561

    摘要： A process for making water-soluble phosphonooxymethyl ethers of hindered alcohol and phenol containing pharmaceuticals, such as camptothecin, propofol, etoposide, Vitamin E and Cyclosporin A. In particular, the process for preparing water-soluble phosphonooxymethyl derivatives comprises the steps of Formula (i) and Formula (ii); R—OH represents an alcohol- or phenol-containing drug, n represents an integer of 1 or 2, R1 is hydrogen, an alkali metal ion, or a pharmaceutically acceptable cation, and R2 is hydrogen, an alkali metal ion, or a pharmaceutically acceptable cation

    摘要翻译： 一种制备受阻醇和含苯酚的药物，如喜树碱，异丙酚，依托泊苷，维生素E和环孢菌素A的水溶性膦酰氧基甲基醚的方法。特别地，制备水溶性膦酰氧基甲基衍生物的方法包括以下步骤：式 ）和式（ii）; R-OH表示含醇或苯酚的药物，n表示1或2的整数，R 1是氢，碱金属离子或药学上可接受的阳离子， 2是氢，碱金属离子或药学上可接受的阳离子

    Process for preparing water-soluble phosphonooxymethyl derivatives of alcohol and phenol
    7.
    发明申请
    Process for preparing water-soluble phosphonooxymethyl derivatives of alcohol and phenol 失效
    制备醇和苯酚的水溶性膦酰氧甲基衍生物的方法

    公开(公告)号：US20070043206A1

    公开(公告)日：2007-02-22

    申请号：US11586576

    申请日：2006-10-26

    申请人： George Bonneville ,  Greg Delahanty ,  Andrew Walz

    发明人： George Bonneville ,  Greg Delahanty ,  Andrew Walz

    IPC分类号： A61K38/12

    CPC分类号： C07K7/645 ,  C07F9/091 ,  C07F9/65522 ,  C07F9/6561

    摘要： A process for making water-soluble phosphonooxymethyl ethers of hindered alcohol and phenol containing pharmaceuticals, such as camptothecin, propofol, etoposide, Vitamin E and Cyclosporin A. In particular, the process for preparing water-soluble phosphonooxymethyl derivatives comprises the steps of: R—OH represents an alcohol- or phenol-containing drug, n represents an integer of 1 or 2, R1 is hydrogen, an alkali metal ion, or a pharmaceutically acceptable cation, and R2 is hydrogen, an alkali metal ion, or a pharmaceutically acceptable cation.

    摘要翻译： 一种制备受阻醇和含苯酚的药物，如喜树碱，异丙酚，依托泊苷，维生素E和环孢菌素A的水溶性膦酰氧甲基醚的方法。特别地，制备水溶性膦酰氧甲基衍生物的方法包括以下步骤：R- OH表示含醇或苯酚的药物，n表示1或2的整数，R 1是氢，碱金属离子或药学上可接受的阳离子，R 2， / SUP>是氢，碱金属离子或药学上可接受的阳离子。