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公开(公告)号：US08288365B2
公开(公告)日：2012-10-16
申请号：US13014281
申请日：2011-01-26
IPC分类号： A61K31/655 , C07D213/76
CPC分类号： C07D213/77 , C07D401/12
摘要： The present invention is directed to substituted phenazopyridines represented by Formula I. The present invention also relates to the discovery that compounds of Formula I have increased bioavailability as compared to unconjugated phenazopyridine.
摘要翻译： 本发明涉及由式I表示的取代的吩噻嗪类。本发明还涉及与未缀合的非那吡啶相比，式I化合物具有增加的生物利用度的发现。
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公开(公告)号：US20110319367A1
公开(公告)日：2011-12-29
申请号：US13014281
申请日：2011-01-26
IPC分类号： A61K31/655 , A61P25/04 , C07D213/76
CPC分类号： C07D213/77 , C07D401/12
摘要： The present invention is directed to substituted phenazopyridines represented by Formula I. The present invention also relates to the discovery that compounds of Formula I have increased bioavailability as compared to unconjugated phenazopyridine.
摘要翻译： 本发明涉及由式I表示的取代的吩噻嗪类。本发明还涉及与未缀合的非那吡啶相比，式I化合物具有增加的生物利用度的发现。
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公开(公告)号：US07893042B2
公开(公告)日：2011-02-22
申请号：US12645099
申请日：2009-12-22
IPC分类号： A61K31/655 , C07D213/75 , A61P13/02
CPC分类号： C07D213/77 , C07D401/12
摘要： The present invention is directed to substituted phenazopyridines represented by Formula I. The present invention also relates to the discovery that compounds of Formula I have increased bioavailability as compared to unconjugated phenazopyridine.
摘要翻译： 本发明涉及由式I表示的取代的吩噻嗪类。本发明还涉及与未缀合的非那吡啶相比，式I化合物具有增加的生物利用度的发现。
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4.发明授权Multifunctional radical quenchers for the treatment of mitochondrial dysfunction 有权多功能自由基猝灭剂治疗线粒体功能障碍公开(公告)号：US09388163B2
公开(公告)日：2016-07-12
申请号：US14731950
申请日：2015-06-05
IPC分类号： C07D279/20 , C07D213/74 , C07D211/94 , C07D401/06 , G01N33/50 , C07D213/89 , C07D279/18
CPC分类号： C07D401/06 , C07D211/94 , C07D213/74 , C07D213/89 , C07D279/18 , C07D279/20 , G01N33/5079
摘要： The present disclosure provides methods for identifying therapeutic agents that are multifunctional radical quenchers. It also provides compounds of formula: and pharmaceutically acceptable salts thereof, compositions comprising these compounds, and methods of using these compounds in a variety of applications, such as treatment or suppression of diseases associated with decreased mitochondrial function resulting in diminished ATP production and/or oxidative stress and/or lipid peroxidation.
摘要翻译： 本公开提供了用于鉴定作为多功能自由基猝灭剂的治疗剂的方法。 它还提供式：及其药学上可接受的盐的化合物，包含这些化合物的组合物，以及在各种应用中使用这些化合物的方法，例如治疗或抑制与减少的线粒体功能相关的疾病，导致ATP产生减少和/或 氧化应激和/或脂质过氧化。
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5.发明申请公开(公告)号：US20140038963A1
公开(公告)日：2014-02-06
申请号：US14009437
申请日：2012-04-04
IPC分类号： C07D211/94 , C07D279/20 , C07D401/06 , G01N33/50
CPC分类号： C07D401/06 , C07D211/94 , C07D213/74 , C07D213/89 , C07D279/18 , C07D279/20 , G01N33/5079
摘要： The present disclosure provides methods for identifying therapeutic agents that are multifunctional radical quenchers. It also provides compounds of formula (I), (II), or (II-A): and pharmaceutically acceptable salts thereof, compositions comprising these compounds, and methods of using these compounds in a variety of applications, such as treatment or suppression of diseases associated with decreased mitochondrial function resulting in diminished ATP production and/or oxidative stress and/or lipid peroxidation.
摘要翻译： 本公开提供了用于鉴定作为多功能自由基猝灭剂的治疗剂的方法。 它还提供式（I），（II）或（II-A）的化合物及其药学上可接受的盐，包含这些化合物的组合物，以及在各种应用中使用这些化合物的方法，例如治疗或抑制 与线粒体功能降低相关的疾病导致ATP产生和/或氧化应激和/或脂质过氧化降低。
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6.发明申请公开(公告)号：US20130266518A1
公开(公告)日：2013-10-10
申请号：US13910565
申请日：2013-06-05
申请人： Sidney Hecht , Marek Belohlavek
发明人： Sidney Hecht , Marek Belohlavek
CPC分类号： A61K9/0087 , A61K47/6925 , A61K49/223
摘要： Methods and compositions for using tumor targeting compounds bound to microbubbles to facilitate drug delivery and diagnostic imaging at tumor sites.
摘要翻译： 使用结合微泡的肿瘤靶向化合物促进肿瘤部位的药物递送和诊断成像的方法和组合物。
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7.发明申请公开(公告)号：US20110293530A1
公开(公告)日：2011-12-01
申请号：US13128142
申请日：2009-11-23
申请人： Sidney Hecht , Marek Belohlavek
发明人： Sidney Hecht , Marek Belohlavek
CPC分类号： A61K9/0087 , A61K47/6925 , A61K49/223
摘要： Methods and compositions for using tumor targeting compounds bound to microbubbles to facilitate drug delivery and diagnostic imaging at tumor sites.
摘要翻译： 使用结合微泡的肿瘤靶向化合物促进肿瘤部位的药物递送和诊断成像的方法和组合物。
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8.发明申请Side-chain variants of redox-active therapeutics for treatment of mitochondrial diseases and other conditions and modulation of energy biomarkers 有权用于治疗线粒体疾病和其他条件的氧化还原活性治疗剂的侧链变体和能量生物标志物的调节公开(公告)号：US20070225261A1
公开(公告)日：2007-09-27
申请号：US11710042
申请日：2007-02-22
申请人： Guy Miller , Sidney Hecht , Orion Jankowski , Kieron Wesson , Paul Mollard
发明人： Guy Miller , Sidney Hecht , Orion Jankowski , Kieron Wesson , Paul Mollard
IPC分类号： A61K31/66 , A61K31/655 , A61K31/55 , C07C50/02 , A61K31/445 , A61K31/40
CPC分类号： C07C50/04 , A61K31/05 , A61K31/355 , C07C39/08 , C07C39/11 , C07C39/19 , C07C39/245 , C07C43/225 , C07C43/23 , C07C47/277 , C07C50/02 , C07C50/06 , C07C50/24 , C07C50/28 , C07C69/608 , C07C69/618 , C07C215/56 , C07C233/27 , C07C233/32 , C07C255/37 , C07C403/04 , C07C403/08 , C07C403/18 , C07C2601/16
摘要： Methods of treating or suppressing mitochondrial diseases, such as Friedreich's ataxia (FRDA), Leber's Hereditary Optic Neuropathy (LHON), mitochondrial myopathy, encephalopathy, lactacidosis, stroke (MELAS), or Kearns-Sayre Syndrome (KSS) are disclosed, as well as compounds useful in the methods of the invention. Methods and compounds useful in treating other disorders are also disclosed. Energy biomarkers useful in assessing the metabolic state of a subject and the efficacy of treatment are also disclosed. Methods of modulating, normalizing, or enhancing energy biomarkers, as well as compounds useful for such methods, are also disclosed.
摘要翻译： 公开了治疗或抑制线粒体疾病如弗里德里希共济失调（FRDA），莱伯氏遗传性视神经病变（LHON），线粒体肌病，脑病，乳酸脱落症，中风（MELAS）或Kearns-Sayre综合征（KSS）的方法，以及 可用于本发明方法的化合物。 还公开了可用于治疗其它疾病的方法和化合物。 还公开了可用于评估受试者的代谢状态和治疗功效的能量生物标志物。 还公开了调节，归一化或增强能量生物标志物的方法以及可用于这些方法的化合物。
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9.发明申请Redox-active therapeutics for treatment of mitochondrial diseases and other conditions and modulation of energy biomarkers 有权用于治疗线粒体疾病和其他条件的氧化还原活性治疗剂和能量生物标志物的调节公开(公告)号：US20060281809A1
公开(公告)日：2006-12-14
申请号：US11445582
申请日：2006-06-01
申请人： Guy Miller , Sidney Hecht
发明人： Guy Miller , Sidney Hecht
CPC分类号： C07C37/07 , A61K31/355 , C07C39/08 , C07C39/19 , C07C39/24 , C07C39/245 , C07C46/00 , C07C46/02 , C07C46/08 , C07C50/02 , C07C50/06 , C07C50/28 , C07C50/24 , C07C39/11 , C07C39/04
摘要： Methods of treating or suppressing mitochondrial diseases, such as Friedreich's ataxia (FRDA), Leber's Hereditary Optic Neuropathy (LHON), mitochondrial myopathy, encephalopathy, lactacidosis, stroke (MELAS), or Kearns-Sayre Syndrome (KSS) are disclosed, as well as compounds useful in the methods of the invention, such as alpha-tocopherol quinone. Methods and compounds useful in treating other disorders are also disclosed. Energy biomarkers useful in assessing the metabolic state of a subject and the efficacy of treatment are also disclosed. Methods of modulating, normalizing, or enhancing energy biomarkers, as well as compounds useful for such methods, are also disclosed.
摘要翻译： 公开了治疗或抑制线粒体疾病如弗里德里希共济失调（FRDA），莱伯氏遗传性视神经病变（LHON），线粒体肌病，脑病，乳酸脱落症，中风（MELAS）或Kearns-Sayre综合征（KSS）的方法，以及 可用于本发明方法的化合物，例如α-生育酚醌。 还公开了可用于治疗其它疾病的方法和化合物。 还公开了可用于评估受试者的代谢状态和治疗功效的能量生物标志物。 还公开了调节，归一化或增强能量生物标志物的方法以及可用于这些方法的化合物。
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公开(公告)号：US20150274628A1
公开(公告)日：2015-10-01
申请号：US14434725
申请日：2013-10-10
申请人： Manikandadas, Mathilakathu MADATHIL , Omar KHDOUR , Sidney HECHT , ARIZONA BOARD OF REGENTS, A BODY CORPORATE OF THE STATE OF ARIZONA, ACTING FOR AN ON BEHALF OF ARIZO
IPC分类号： C07C49/753 , C07C229/10 , C07D225/06 , C07C225/20
CPC分类号： C07C49/753 , A61K9/0019 , A61K9/008 , A61K9/08 , A61K9/2018 , A61K9/2054 , A61K9/4858 , C07C46/02 , C07C225/20 , C07C229/10 , C07D225/06 , C07C50/28
摘要： The invention provides a compound of formula (I): [insert formula (I)] wherein X, Y, and R1-R4 have any of the values defined in the specification, and salts thereof, as well as compositions comprising the compounds or salts. The compounds are useful for treating diseases associated with impaired mitochondrial function in an animal.
摘要翻译： 本发明提供式（I）化合物：[插入式（I）]其中X，Y和R 1 -R 4具有说明书中定义的任何值及其盐，以及包含化合物或盐的组合物 。 该化合物可用于治疗与动物线粒体功能受损相关的疾病。
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