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公开(公告)号：US07456028B2
公开(公告)日：2008-11-25
申请号：US10252342
申请日：2002-09-23
IPC分类号： G01N33/543
CPC分类号： G01N33/5438 , B01J2219/00317 , B01J2219/00511 , B01J2219/00585 , B01J2219/00596 , B01J2219/00653 , B01J2219/00659 , B01J2219/00704 , B01L3/502761 , B01L7/52 , B01L2400/0415 , B01L2400/043 , C12Q2565/607 , F04B17/00 , G01N27/3277 , G01N2333/44
摘要： A novel, surface immobilization electrochemical assay allows for rapid, accurate and highly sensitive detection of microorganisms and biological molecules. Known surface immobilization methods are utilized to bind an analyte to a surface. A binding material with a covalently attached electroactive complex generates electrical current in the presence of analyte. An electrode is used to detect the current, that is directly related to the concentration of analyte. The invention is especially suitable for detection of Cryptospiridium parvum.
摘要翻译： 一种新颖的表面固定电化学测定法允许微生物和生物分子的快速，准确和高度灵敏的检测。 已知的表面固定方法用于将分析物结合到表面。 具有共价连接的电活性复合物的结合材料在分析物存在下产生电流。 电极用于检测与分析物浓度直接相关的电流。 本发明特别适合于检测小檗碱。
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公开(公告)号：US20120189700A1
公开(公告)日：2012-07-26
申请号：US13350849
申请日：2012-01-16
申请人： Zoraida Aguilar , Yongqiang Wang , Hengyi Xu , George Hui , Kae Pusic
发明人： Zoraida Aguilar , Yongqiang Wang , Hengyi Xu , George Hui , Kae Pusic
IPC分类号： A61K39/385 , A61P35/00 , A61K9/51 , B82Y5/00
CPC分类号： A61K39/39 , A61K9/0019 , A61K9/5176 , A61K39/015 , A61K47/6923 , A61K47/6929 , A61K2039/505 , A61K2039/55555 , A61K2039/55566 , C07K16/205 , C07K2317/73 , C12N2799/026
摘要： A nanoparticle-based delivery system and methods for its use are disclosed. In one aspect, a nanoparticle-based delivery system comprising at least one molecule such as proteins, DNA/RNA or fragments thereof, carbohydrates, enzymes, chemicals, virus cells, bacteria, parts of a virus, parts of a bacteria, parts of a cell, part of a tissue, or a combination of one or more of these, which shall be referred to as immunogens, are chemically or physically combined with water soluble nanoparticles which, when administered to a living system, is capable of eliciting a desired immunological response. More particularly, the invention relates to nanoparticle-based delivery systems that are specifically engineered to enhance humoral or cellular immune response without the use of adjuvants.
摘要翻译： 公开了一种基于纳米颗粒的递送系统及其使用方法。 一方面，包含至少一种分子如蛋白质，DNA / RNA或其片段，碳水化合物，酶，化学物质，病毒细胞，细菌，部分病毒，部分细菌的纳米粒子递送系统 细胞，组织的一部分或这些中的一种或多种的组合，其称为免疫原，与水溶性纳米颗粒化学或物理组合，当其施用于活体系时，能够引发所需的免疫学 响应。 更具体地，本发明涉及专门设计用于增强体液或细胞免疫应答而不使用佐剂的基于纳米颗粒的递送系统。
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公开(公告)号：US07348183B2
公开(公告)日：2008-03-25
申请号：US10253187
申请日：2002-09-24
IPC分类号： G01N33/543
CPC分类号： B01J19/0046 , B01F13/0077 , B01J2219/00317 , B01J2219/00511 , B01J2219/00585 , B01J2219/00596 , B01J2219/00653 , B01J2219/00659 , B01J2219/00704 , B01L3/5027 , B01L3/502707 , B01L3/5085 , B01L2200/0605 , B01L2400/0415 , B01L2400/043 , C12Q2565/607 , F04B17/00 , G01N27/3278 , G01N33/5438
摘要： Methods and devices for improved chemical and biomass detection assays combined well defined microstructures having independently addressable electrodes with various surface immobilization electrochemical assays. Combining known chemical detection immobilization assays, electrochemically active moieties with microstructures having independently addressable electrodes provides for vastly improved methods of detecting microorganisms, chemical compounds, and measuring membrane transport.
摘要翻译： 用于改进化学和生物量检测测定的方法和装置将具有独立可寻址电极的明确定义的微结构与各种表面固定电化学测定相结合。 结合已知的化学检测固定化测定法，具有独立寻址电极的微结构的电化学活性部分提供了极大地改进的检测微生物，化合物和测量膜转运的方法。
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公开(公告)号：US07645615B1
公开(公告)日：2010-01-12
申请号：US12054229
申请日：2008-03-24
IPC分类号： G01N33/543
CPC分类号： B01J19/0046 , B01F13/0077 , B01J2219/00317 , B01J2219/00511 , B01J2219/00585 , B01J2219/00596 , B01J2219/00653 , B01J2219/00659 , B01J2219/00704 , B01L3/5027 , B01L3/502707 , B01L3/5085 , B01L2200/0605 , B01L2400/0415 , B01L2400/043 , C12Q2565/607 , F04B17/00 , G01N27/3278 , G01N33/5438
摘要： Methods and devices for improved chemical and biological detection assays combined well defined microstructures having independently addressable electrodes with various surface immobilization electrochemical assays. Combining known chemical detection immobilization assays, electrochemically active moieties with microstructures having independently addressable electrodes provides for vastly improved methods of detecting microorganisms, chemical compounds, and measuring membrane transport.
摘要翻译： 用于改进化学和生物检测测定的方法和装置将具有独立可寻址电极的明确定义的微结构与各种表面固定电化学测定相结合。 结合已知的化学检测固定化测定法，具有独立寻址电极的微结构的电化学活性部分提供了极大地改进的检测微生物，化合物和测量膜转运的方法。
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5.发明授权Microfluidics and small volume mixing based on redox magnetohydrodynamics methods 有权基于氧化还原磁流体力学方法的微流体和小体积混合公开(公告)号：US06733244B1
公开(公告)日：2004-05-11
申请号：US10026748
申请日：2001-12-19
IPC分类号： F04B3702
CPC分类号： B01F13/0077 , B01L3/50273 , B01L3/502784 , B01L2200/0605 , B01L2400/0415 , B01L2400/043 , F04B17/00 , F04B19/006
摘要： Microfluidic channels utilizing magnetohydrodynamics are used to pump very small volumes of solution. The channels have electrodes along the walls of the channel and a current carrying species within the solution carries the current through the solution. The electric field generated by the use of the current carrying species is perpendicular to a magnetic field applied to the channel. The combination of the electric and magnetic fields causes the solution to flow through the channel.
摘要翻译： 使用磁流体动力学的微流体通道用于泵送非常小体积的溶液。 通道沿着通道的壁具有电极，溶液内的载流物质携带电流通过溶液。 通过使用载流子物质产生的电场垂直于施加到通道的磁场。 电场和磁场的组合导致溶液流过通道。
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