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公开(公告)号：US4950483A
公开(公告)日：1990-08-21
申请号：US286303
申请日：1988-12-16
申请人： George Ksander , Yasushi Ogawa
发明人： George Ksander , Yasushi Ogawa
IPC分类号： A61K38/00 , A61F2/00 , A61K38/17 , A61K38/21 , A61K38/22 , A61K38/27 , A61K38/39 , A61L27/00 , A61L27/24 , A61L27/54 , A61P7/00 , A61P17/00 , A61P35/00 , A61P37/00 , A61P43/00
CPC分类号： A61L27/54 , A61K38/39 , A61L27/24 , A61F2310/00365 , A61L2300/25 , A61L2300/252 , A61L2300/414 , A61L2300/426 , A61L2300/45 , Y10S128/08 , Y10S623/924
摘要： Collagen implants that are useful as wound healing matrices are characterized by being formed of collagen fibrils that are not chemically cross-linked, and having a bulk density of 0.01 to 0.3 g/cm.sup.3 and a pore population in which at least about 80% of the pores have an average pore size of 35 to 250 microns. The implants are capable of promoting connective tissue deposition, angiogenesis, reepithelialization, and fibroplasia. The wound healing matrix also serves an an effective sustained delivery system for synergistic combinations of FGF and TGF-B.
摘要翻译： 可用作伤口愈合基质的胶原植入物的特征在于由不是化学交联的，具有0.01至0.3g / cm 3的堆积密度的胶原原纤维和其中至少约80％ 孔的平均孔径为35至250微米。 植入物能够促进结缔组织沉积，血管生成，再上皮细胞化和纤维增生。 伤口愈合基质还用于有效的持续递送系统，用于FGF和TGF-B的协同组合。
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公开(公告)号：US5110604A
公开(公告)日：1992-05-05
申请号：US630299
申请日：1990-12-19
申请人： George H. Chu , Yasushi Ogawa , John M. McPherson , George Ksander , Bruce Pratt , Diana Hendricks , Hugh McMullin
发明人： George H. Chu , Yasushi Ogawa , John M. McPherson , George Ksander , Bruce Pratt , Diana Hendricks , Hugh McMullin
CPC分类号： A61L27/24 , A61K38/39 , A61L27/54 , A61F2310/00365 , A61L2300/252 , A61L2300/414 , A61L2300/426 , Y10S128/08 , Y10S514/801 , Y10S623/915
摘要： Collagen implants that are useful as wound healing matrices are characterized by being formed of collagen fibrils that are not chemically cross-linked, and having a bulk density of 0.01 to 0.3 g/cm.sup.3 and a pore population in which at least about 80% of the pores have an average pore size of 35 to 250 microns. The implants are capable of promoting connective tissue deposition, angiogenesis, reepithelialization, and fibroplasia. The wound healing matrix also serves as an effective sustained delivery system for bioactive agents.
摘要翻译： 可用作伤口愈合基质的胶原植入物的特征在于由不是化学交联的，具有0.01至0.3g / cm 3的堆积密度的胶原原纤维和其中至少约80％ 孔的平均孔径为35至250微米。 植入物能够促进结缔组织沉积，血管生成，再上皮细胞化和纤维增生。 伤口愈合基质还可用作生物活性剂的有效持续递送系统。
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公开(公告)号：US5024841A
公开(公告)日：1991-06-18
申请号：US213726
申请日：1988-06-30
申请人： George H. Chu , Yasushi Ogawa , John M. McPherson , George Ksander , Bruce Pratt , Diana Hendricks , Hugh McMullin
发明人： George H. Chu , Yasushi Ogawa , John M. McPherson , George Ksander , Bruce Pratt , Diana Hendricks , Hugh McMullin
CPC分类号： A61L27/54 , A61K38/39 , A61L27/24 , A61F2310/00365 , A61L2300/414 , Y10S128/08 , Y10S514/801
摘要： Collagen implants that are useful as wound healing matrices are characterized by being formed of collagen fibrils that are not chemically cross-linked, and having a bulk density of 0.01 to 0.3 g/cm.sup.3 and a pore population in which at least about 80% of the pores have an average pore size of 35 to 250 microns. The implants are capable of promoting connective tissue deposition, angiogenesis, reepithelialization, and fibroplasia. The wound healing matrix also serves as an effective sustained delivery system for bioactive agents.
摘要翻译： 可用作伤口愈合基质的胶原植入物的特征在于由不是化学交联的，具有0.01至0.3g / cm 3的堆积密度的胶原原纤维和其中至少约80％ 孔的平均孔径为35至250微米。 植入物能够促进结缔组织沉积，血管生成，再上皮细胞化和纤维增生。 伤口愈合基质还可用作生物活性剂的有效持续递送系统。
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公开(公告)号：US4772285A
公开(公告)日：1988-09-20
申请号：US925464
申请日：1986-10-30
申请人： George Ksander , Leonard Gray
发明人： George Ksander , Leonard Gray
CPC分类号： A61F2/02 , A61L27/34 , Y10S128/08
摘要： An improved soft tissue implant which resists capsule formation and contracture is described. The implant is coated with a non-immunogenic collagen preparation optionally stabilized by crosslinking.
摘要翻译： 描述了改进的抵抗胶囊形成和挛缩的软组织植入物。 植入物涂覆有任选通过交联稳定的非免疫原性胶原制剂。
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公开(公告)号：US5219576A
公开(公告)日：1993-06-15
申请号：US801732
申请日：1991-12-03
申请人： George H. Chu , Yasushi Ogawa , John M. McPherson , George Ksander , Bruce Pratt , Diana Hendricks , Hugh McMullin
发明人： George H. Chu , Yasushi Ogawa , John M. McPherson , George Ksander , Bruce Pratt , Diana Hendricks , Hugh McMullin
CPC分类号： A61K38/39 , A61L27/24 , A61L27/54 , A61F2310/00365 , A61L2300/414 , Y10S128/08 , Y10S514/801 , Y10S514/887
摘要： Collagen implants that are useful as wound healing matrices are characterized by being formed of collagen fibrils that are not chemically cross-linked, and having a bulk density of 0.01 to 0.3 g/cm.sup.3 and a pore population in which at least about 80% of the pores have an average pore size of 35 to 250 microns. The implants are capable of promoting connective tissue deposition, angiogenesis, reepithelialization, and fibroplasia. The wound healing matrix also serves as an effective sustained delivery system for bioactive agents.
摘要翻译： 可用作伤口愈合基质的胶原植入物的特征在于由不是化学交联的，具有0.01至0.3g / cm 3的堆积密度的胶原原纤维和其中至少约80％ 孔的平均孔径为35至250微米。 植入物能够促进结缔组织沉积，血管生成，再上皮细胞化和纤维增生。 伤口愈合基质还可用作生物活性剂的有效持续递送系统。
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