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公开(公告)号：US5024841A
公开(公告)日：1991-06-18
申请号：US213726
申请日：1988-06-30
申请人： George H. Chu , Yasushi Ogawa , John M. McPherson , George Ksander , Bruce Pratt , Diana Hendricks , Hugh McMullin
发明人： George H. Chu , Yasushi Ogawa , John M. McPherson , George Ksander , Bruce Pratt , Diana Hendricks , Hugh McMullin
CPC分类号： A61L27/54 , A61K38/39 , A61L27/24 , A61F2310/00365 , A61L2300/414 , Y10S128/08 , Y10S514/801
摘要： Collagen implants that are useful as wound healing matrices are characterized by being formed of collagen fibrils that are not chemically cross-linked, and having a bulk density of 0.01 to 0.3 g/cm.sup.3 and a pore population in which at least about 80% of the pores have an average pore size of 35 to 250 microns. The implants are capable of promoting connective tissue deposition, angiogenesis, reepithelialization, and fibroplasia. The wound healing matrix also serves as an effective sustained delivery system for bioactive agents.
摘要翻译： 可用作伤口愈合基质的胶原植入物的特征在于由不是化学交联的，具有0.01至0.3g / cm 3的堆积密度的胶原原纤维和其中至少约80％ 孔的平均孔径为35至250微米。 植入物能够促进结缔组织沉积，血管生成，再上皮细胞化和纤维增生。 伤口愈合基质还可用作生物活性剂的有效持续递送系统。
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公开(公告)号：US5219576A
公开(公告)日：1993-06-15
申请号：US801732
申请日：1991-12-03
申请人： George H. Chu , Yasushi Ogawa , John M. McPherson , George Ksander , Bruce Pratt , Diana Hendricks , Hugh McMullin
发明人： George H. Chu , Yasushi Ogawa , John M. McPherson , George Ksander , Bruce Pratt , Diana Hendricks , Hugh McMullin
CPC分类号： A61K38/39 , A61L27/24 , A61L27/54 , A61F2310/00365 , A61L2300/414 , Y10S128/08 , Y10S514/801 , Y10S514/887
摘要： Collagen implants that are useful as wound healing matrices are characterized by being formed of collagen fibrils that are not chemically cross-linked, and having a bulk density of 0.01 to 0.3 g/cm.sup.3 and a pore population in which at least about 80% of the pores have an average pore size of 35 to 250 microns. The implants are capable of promoting connective tissue deposition, angiogenesis, reepithelialization, and fibroplasia. The wound healing matrix also serves as an effective sustained delivery system for bioactive agents.
摘要翻译： 可用作伤口愈合基质的胶原植入物的特征在于由不是化学交联的，具有0.01至0.3g / cm 3的堆积密度的胶原原纤维和其中至少约80％ 孔的平均孔径为35至250微米。 植入物能够促进结缔组织沉积，血管生成，再上皮细胞化和纤维增生。 伤口愈合基质还可用作生物活性剂的有效持续递送系统。
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公开(公告)号：US5110604A
公开(公告)日：1992-05-05
申请号：US630299
申请日：1990-12-19
申请人： George H. Chu , Yasushi Ogawa , John M. McPherson , George Ksander , Bruce Pratt , Diana Hendricks , Hugh McMullin
发明人： George H. Chu , Yasushi Ogawa , John M. McPherson , George Ksander , Bruce Pratt , Diana Hendricks , Hugh McMullin
CPC分类号： A61L27/24 , A61K38/39 , A61L27/54 , A61F2310/00365 , A61L2300/252 , A61L2300/414 , A61L2300/426 , Y10S128/08 , Y10S514/801 , Y10S623/915
摘要： Collagen implants that are useful as wound healing matrices are characterized by being formed of collagen fibrils that are not chemically cross-linked, and having a bulk density of 0.01 to 0.3 g/cm.sup.3 and a pore population in which at least about 80% of the pores have an average pore size of 35 to 250 microns. The implants are capable of promoting connective tissue deposition, angiogenesis, reepithelialization, and fibroplasia. The wound healing matrix also serves as an effective sustained delivery system for bioactive agents.
摘要翻译： 可用作伤口愈合基质的胶原植入物的特征在于由不是化学交联的，具有0.01至0.3g / cm 3的堆积密度的胶原原纤维和其中至少约80％ 孔的平均孔径为35至250微米。 植入物能够促进结缔组织沉积，血管生成，再上皮细胞化和纤维增生。 伤口愈合基质还可用作生物活性剂的有效持续递送系统。
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公开(公告)号：US5425770A
公开(公告)日：1995-06-20
申请号：US99610
申请日：1993-07-30
CPC分类号： A61L27/46 , A61F2002/2835 , A61L2430/02 , Y10S128/08 , Y10S623/923
摘要： Processes for the preparation of compositions used in conductive bone repair are disclosed. The compositions contain a mixture consisting essentially of either a calcium phosphate particulate mineral component or particulate hydroxyapatite in admixture with atelopeptide reconstituted fibrillar collagen. The method is comprised of mixing a dispersion of the collagen and mineral, the latter which is present in dry particulate form, followed by molding and drying the composition in a mold to obtain a dried composition.
摘要翻译： 公开了用于制备用于导电骨修复的组合物的方法。 组合物含有基本上由磷酸钙颗粒状矿物组分或颗粒状羟基磷灰石组成的混合物，与磷酸腺苷重构的纤维状胶原混合。 该方法包括混合胶原蛋白和矿物质的分散体，后者以干燥颗粒形式存在，然后在模具中成型和干燥组合物以获得干燥的组合物。
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公开(公告)号：US4795467A
公开(公告)日：1989-01-03
申请号：US848443
申请日：1986-04-04
CPC分类号： A61L27/46 , A61F2002/2835 , A61L2430/02 , Y10S514/801
摘要： A composition for use in bone repair, in particular, in onlay procedures, which comprises calcium phosphate mineral particles in admixture with atelopeptide reconstituted fibrillar collagen preparations is disclosed. This composition is non-immunogenic and encourages the fusion of host bone with new bone growth through the implant. Additional processes for curing the implant to improve its compressive strength include heat curing, maturation, and cross-linking.
摘要翻译： 公开了一种用于骨修复的组合物，特别是在包含磷灰石矿物颗粒与阿替肽复构的纤维状胶原蛋白制剂混合的敷贴方法中。 该组合物是非免疫原性的，并且通过植入物促进宿主骨与新骨生长的融合。 用于固化植入物以提高其抗压强度的其它方法包括热固化，成熟和交联。
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公开(公告)号：US5246457A
公开(公告)日：1993-09-21
申请号：US629074
申请日：1990-12-17
CPC分类号： A61L27/46 , A61F2002/2835 , A61L2430/02 , Y10S128/08 , Y10S623/923
摘要： A composition for use in bone repair, in particular, in only procedures, which comprises calcium phosphate mineral particles in admixture with atelopeptide reconstituted fibrillar collagen preparations is disclosed. This composition is non-immunogenic and encourages the fusion of host bone with new bone growth through the implant. Additional processes for curing the implant to improve its compressive strength include heat curing, maturation, and cross-linking.
摘要翻译： 公开了一种用于骨修复的组合物，特别是在仅包含磷酸钙矿物颗粒与阿替肽重构纤维状胶原蛋白制剂混合的方法中。 该组合物是非免疫原性的，并且通过植入物促进宿主骨与新骨生长的融合。 用于固化植入物以提高其抗压强度的其它方法包括热固化，成熟和交联。
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7.发明授权Method of making molds with xenogeneic collagen/mineral preparations for bone repair 失效用于骨修复的异种胶原蛋白/矿物质制剂的制备方法
公开(公告)号：US4992226A
公开(公告)日：1991-02-12
申请号：US245449
申请日：1988-09-16
CPC分类号： A61L27/46 , A61F2002/2835 , A61L2430/02 , Y10S623/901 , Y10S623/923
摘要： A process for coating the pores of a mineral matrix with collagen by pumping collagen through the molded matrix is disclosed. The resulting coated matrix can be used as a prosthesis in bone repair.
摘要翻译： 公开了一种通过将胶原蛋白泵送通过模塑基质来涂覆矿物基质的孔的方法。 所得涂层基质可用作骨修复中的假体。
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公开(公告)号：US08617584B2
公开(公告)日：2013-12-31
申请号：US12787304
申请日：2010-05-25
申请人： Louis C. Sehl , Olof Mikael Trollsas , Donald G. Wallace , David Toman , Frank A. DeLustro , Jacqueline A. Schroeder , George H. Chu
发明人： Louis C. Sehl , Olof Mikael Trollsas , Donald G. Wallace , David Toman , Frank A. DeLustro , Jacqueline A. Schroeder , George H. Chu
IPC分类号： A61F13/00
CPC分类号： A61L24/043 , A61F2/0063 , A61L24/08 , A61L24/102 , A61L27/24 , A61L27/26 , A61L31/041 , A61L31/044 , C08B37/0075 , C08F283/00 , C08F283/04 , C08F283/06 , C08G65/329 , C08G75/045 , C08G75/26 , C08H1/00 , C08H1/06 , C08L51/003 , C08L53/00 , C08L67/06 , C08L71/02 , C08L81/02 , C09D167/02 , C09J151/003 , C09J153/00 , C09J189/06 , C08L89/06 , C08L5/16 , C08L91/06 , C08L2666/26 , C08L71/00
摘要： The present invention relates generally to synthetic polymer compositions that form interpenetrating polymer networks. In a preferred embodiment, the compositions comprise two multifunctionally activated synthetic polymers, along with a tensile strength enhancer. Such compositions form matrices that exhibit superior cohesive strength and in many instances can serve as adequate replacements for surgical means of attaching tissues, such as sutures, sponges and medical staples.
摘要翻译： 本发明一般涉及形成互穿聚合物网络的合成聚合物组合物。 在优选的实施方案中，组合物包含两种多功能活化的合成聚合物以及拉伸强度增强剂。 这样的组合物形成表现出优异的内聚强度的基质，并且在许多情况下可用作适当的替代物，用于附接组织例如缝合线，海绵和医用缝钉的外科手段。
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公开(公告)号：US5786421A
公开(公告)日：1998-07-28
申请号：US853045
申请日：1997-05-06
申请人： Woonza M. Rhee , Prema R. Rao , George H. Chu , Frank A. DeLustro , Carol F. H. Harner , Naomi Sakai , Jacqueline A. Schroeder
发明人： Woonza M. Rhee , Prema R. Rao , George H. Chu , Frank A. DeLustro , Carol F. H. Harner , Naomi Sakai , Jacqueline A. Schroeder
IPC分类号： A61L24/00 , A61F2/00 , A61F2/06 , A61K38/00 , A61K47/48 , A61L24/10 , A61L26/00 , A61L27/18 , A61L27/20 , A61L27/24 , A61L27/26 , A61L27/34 , A61L27/44 , A61L27/54 , A61L29/04 , A61L29/06 , A61L29/16 , A61L31/04 , A61L31/10 , A61L31/12 , C07K14/495 , C07K14/78 , C08B37/08 , C08H1/06 , C08L89/06 , C09J189/06 , A61F13/00 , A61B17/07
CPC分类号： A61L31/044 , A61K47/48215 , A61K47/4823 , A61L24/102 , A61L26/0033 , A61L27/24 , A61L27/26 , A61L27/34 , A61L27/44 , A61L27/54 , A61L31/041 , A61L31/10 , A61L31/125 , C07K14/495 , C07K14/78 , C08B37/0069 , C08B37/0072 , C08H1/06 , C08L89/06 , C09J189/06 , A61F2/07 , A61F2310/00365 , A61K38/00 , A61L2300/414 , A61L2430/16 , Y10S530/84 , Y10S602/904
摘要： Collagen-based compositions useful in the attachment of tissues, or the attachment of tissues to synthetic implant materials, are disclosed. The compositions comprise collagen crosslinked using a multifunctionally activated synthetic hydrophilic polymer. A particularly preferred composition comprises fibrillar collagen, a fiber disassembly agent, and a multifunctionally activated synthetic hydrophilic polymer. Methods are disclosed for using the compositions to effect the attachment of a native tissue to the surface of another native tissue, a non-native tissue, or a synthetic implant. Also disclosed are methods of using the compositions to prevent the formation of surgical adhesions.
摘要翻译： 公开了可用于组织附着的基于胶原的组合物，或将组织附着于合成植入材料。 组合物包括使用多功能活化的合成亲水性聚合物交联的胶原蛋白。 特别优选的组合物包括纤维胶原，纤维分解剂和多功能活化的合成亲水性聚合物。 公开了使用组合物来实现天然组织附着到另一天然组织，非天然组织或合成植入物的表面的方法。 还公开了使用该组合物来防止手术粘连形成的方法。
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10.发明授权Clear, chemically modified collagen-synthetic polymer conjugates for ophthalmic applications 失效透明的化学改性胶原蛋白合成聚合物共轭物用于眼科应用
公开(公告)号：US5565519A
公开(公告)日：1996-10-15
申请号：US147227
申请日：1993-11-03
申请人： Woonza M. Rhee , Prema R. Rao , George H. Chu , Frank A. DeLustro
发明人： Woonza M. Rhee , Prema R. Rao , George H. Chu , Frank A. DeLustro
IPC分类号： A61L27/00 , A61F2/00 , A61F2/06 , A61K38/00 , A61K47/48 , A61L24/10 , A61L26/00 , A61L27/18 , A61L27/20 , A61L27/24 , A61L27/26 , A61L27/34 , A61L27/44 , A61L27/54 , A61L29/04 , A61L29/06 , A61L29/16 , A61L31/04 , A61L31/10 , A61L31/12 , C07K14/495 , C07K14/78 , C08B37/08 , C08H1/00 , C08H1/06 , C08L89/06 , C09J189/06 , C08G63/48 , C08G63/91
CPC分类号： A61K47/48215 , A61K47/4823 , A61L24/102 , A61L26/0033 , A61L27/18 , A61L27/20 , A61L27/24 , A61L27/26 , A61L27/34 , A61L27/44 , A61L27/54 , A61L29/043 , A61L29/045 , A61L29/06 , A61L29/16 , A61L31/041 , A61L31/044 , A61L31/10 , A61L31/125 , C07K14/495 , C07K14/78 , C08B37/0069 , C08B37/0072 , C08H1/06 , C08L89/06 , C09J189/06 , A61F2/07 , A61F2310/00365 , A61K38/00 , A61L2300/414 , A61L2300/426 , A61L2300/802 , A61L2430/16
摘要： Various forms of chemically modified collagen are covalently crosslinked with activated synthetic hydrophilic polymers to form optically clear biocompatible conjugates useful in a variety of medical applications, particularly in ophthalmic devices. The chemically modified collagen is in substantially nonfibrillar form at pH 7 and is preferably succinylated or methylated collagen. The synthetic hydrophilic polymer is preferably an activated polymeric glycol, most preferably, a di- or multifunctionally activated polyethylene glycol. Materials and devices formed with the chemically modified collagen-synthetic polymer conjugates have good optical clarity, mechanical strength, and moldability.
摘要翻译： 各种形式的化学修饰的胶原与活化的合成亲水性聚合物共价交联以形成用于各种医学应用的光学透明的生物相容性缀合物，特别是在眼科装置中。 化学修饰的胶原蛋白在pH7下基本上非原纤维形式，优选琥珀酰化或甲基化胶原蛋白。 合成的亲水性聚合物优选为活化的聚合二醇，最优选为二官能或多功能活化的聚乙二醇。 用化学改性的胶原 - 合成聚合物共轭物形成的材料和装置具有良好的光学透明度，机械强度和成型性。
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