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1.发明授权Method of treatment of hemorrhagic disease using a factor VIIa/tissue factor inhibitor 有权使用因子VIIa /组织因子抑制剂治疗出血性疾病的方法公开(公告)号：US07329640B2
公开(公告)日：2008-02-12
申请号：US11520079
申请日：2006-09-12
申请人： George P. Vlasuk
发明人： George P. Vlasuk
IPC分类号： C07K14/00
CPC分类号： A61K38/1767 , A61K38/55
摘要： The present invention provides methods of treating hemorrhagic fevers where selective inhibitors of fVIIa/TF are used as a treatment for hemorrhagic fevers and have therapeutic effects which include ameliorating and/or preventing coagulopathy and inflammatory responses. These inhibitors include certain proteins which are part of a family termed Nematode-Extracted Anticoagulant Proteins (“NAPs”). Other inhibitors include Tissue Factor Pathway Inhibitor (“TFPI”) and TFPI analogs.
摘要翻译： 本发明提供了治疗出血热的方法，其中使用fVIIa / TF的选择性抑制剂作为出血热的治疗，并具有包括改善和/或预防凝血病和炎症反应的治疗效果。 这些抑制剂包括属于称为线虫提取抗凝血蛋白（NAP）的家族的一部分的某些蛋白质。 其他抑制剂包括组织因子途径抑制剂（“TFPI”）和TFPI类似物。
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公开(公告)号：US5328997A
公开(公告)日：1994-07-12
申请号：US54761
申请日：1993-04-28
CPC分类号： C07K14/811 , A61K38/00
摘要： Proteins which specifically inhibit coagulation Factor Xa. The inhibitors, which do not inhibit Factor VIIa, kallikrein, trypsin, chymotrypsin, thrombin, urokinase, tissue plasminogen activator, plasmin, elastase, Factor XIa or S. aureus V8 protease, are polypeptides of 60 amino acid residues. The inhibitors may be purified from Ornithodoros moubata extract, synthesized, or produced using a recombinant DNA yeast expression system.
摘要翻译： 特异性抑制凝血因子Xa的蛋白质。 不抑制因子VIIa，激肽释放酶，胰蛋白酶，胰凝乳蛋白酶，凝血酶，尿激酶，组织纤溶酶原激活剂，纤溶酶，弹性蛋白酶，因子XIa或金黄色葡萄球菌V8蛋白酶的抑制剂是60个氨基酸残基的多肽。 抑制剂可以从合成的Ornithodoros moubata提取物中纯化，或使用重组DNA酵母表达系统产生。
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公开(公告)号：US06818616B1
公开(公告)日：2004-11-16
申请号：US08450482
申请日：1995-05-26
申请人： Matthew Moyle , David L. Foster , George P. Vlasuk
发明人： Matthew Moyle , David L. Foster , George P. Vlasuk
IPC分类号： A61K3817
CPC分类号： C07K14/4354 , A61K38/00 , C07K14/535 , F02B2075/027
摘要： Compositions enriched for Neutrophil Inhibitory Factor which inhibit neutrophil activity including adhesion to vascular endothelial cells are provided. Also provided are recombinant Neutrophil Inhibitory Factors which also which inhibit neutrophil activity. Such compositions may comprise a glycoprotein isolated from nematodes. These compositions and recombinant Neutrophil Inhibitory Factors are useful in the therapy of conditions which involve abnormal or undesired inflammatory responses.
摘要翻译： 提供了富含中性粒细胞抑制因子的组合物，其抑制嗜中性粒细胞活性，包括对血管内皮细胞的粘附。 还提供了也抑制中性粒细胞活性的重组嗜中性粒细胞抑制因子。 这样的组合物可以包含从线虫分离的糖蛋白。 这些组合物和重组嗜中性粒细胞抑制因子可用于治疗涉及异常或不期望的炎性反应的病症。
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公开(公告)号：US5789178A
公开(公告)日：1998-08-04
申请号：US458218
申请日：1995-06-02
申请人： Matthew Moyle , David L. Foster , George P. Vlasuk
发明人： Matthew Moyle , David L. Foster , George P. Vlasuk
CPC分类号： C07K16/18 , C07K14/535 , A61K38/00
摘要： Compositions enriched for Neutrophil Inhibitory Factor which inhibit neutrophil activity including adhesion to vascular endothelial cells are provided. Also provided are recombinant Neutrophil Inhibitory Factors which also which inhibit neutrophil activity. Such compositions may comprise a glycoprotein isolated from nematodes. These compositions and recombinant Neutrophil Inhibitory Factors are useful in the therapy of conditions which involve abnormal or undesired inflammatory responses.
摘要翻译： 提供了富含中性粒细胞抑制因子的组合物，其抑制嗜中性粒细胞活性，包括对血管内皮细胞的粘附。 还提供了也抑制中性粒细胞活性的重组嗜中性粒细胞抑制因子。 这样的组合物可以包含从线虫分离的糖蛋白。 这些组合物和重组嗜中性粒细胞抑制因子可用于治疗涉及异常或不期望的炎性反应的病症。
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公开(公告)号：US5656600A
公开(公告)日：1997-08-12
申请号：US37574
申请日：1993-03-25
IPC分类号： A61K38/00 , A61K49/00 , A61K51/08 , A61P7/02 , C07K5/02 , C07K7/02 , C07K14/815 , C07K5/00 , C07K7/00 , C07K17/00
CPC分类号： C07K5/0202 , A61K51/088 , C07K14/815 , A61K2123/00 , A61K38/00
摘要： .alpha.-Ketoamide derivatives, their pharmaceutically acceptable salts, compositions, diagnostic compositions and pharmaceutical compositions, which are useful for preventing or treating in a mammal a pathological condition characterized by thrombosis are described..alpha.-Ketoamide derivatives, their pharmaceutically acceptable salts, compositions and diagnostic compositions, which are useful for in vivo imaging of thrombi in a mammal are also described.Methods of preventing or treating in a mammal a pathological condition characterized by thrombosis and methods of in vivo imaging of thrombi in a mammal are also disclosed.
摘要翻译： 描述了可用于预防或治疗哺乳动物特征在于血栓形成的病理状态的α-甲基酰胺衍生物，其药学上可接受的盐，组合物，诊断组合物和药物组合物。 还描述了可用于哺乳动物血栓体内成像的α-甲基酰胺衍生物，其药学上可接受的盐，组合物和诊断组合物。 还公开了在哺乳动物中预防或治疗血栓形成的特征的病理状态和哺乳动物血栓体内成像方法。
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公开(公告)号：US5597804A
公开(公告)日：1997-01-28
申请号：US139300
申请日：1993-10-18
IPC分类号： A61K38/55 , A61K31/195 , A61K31/198 , A61K31/695 , A61K38/00 , A61K38/06 , A61P7/02 , C07C279/12 , C07C279/36 , C07C307/02 , C07C307/06 , C07C307/08 , C07C307/10 , C07C311/06 , C07C311/13 , C07C311/19 , C07C317/26 , C07D207/16 , C07D211/60 , C07D257/04 , C07D403/06 , C07D403/12 , C07F7/10 , C07K5/06 , C07K5/068 , C07K5/072 , C07K5/078 , C07K5/083 , C07K5/093 , C07K5/097 , C07K5/113 , C07K14/75 , A61K37/00 , C07K5/08 , A61K37/02
CPC分类号： C07D207/16 , C07D211/60 , C07D257/04 , C07K14/75 , C07K5/0606 , C07K5/06086 , C07K5/06113 , C07K5/06139 , C07K5/06165 , C07K5/0806 , C07K5/081 , C07K5/0819 , C07K5/1021 , A61K38/00 , Y10S514/822
摘要： The present invention is directed to N-sulfonyl arginine alpha-keto-amide derivatives, their pharmaceutically acceptable salts and compositions thereof which are useful as antithrombotic agents in mammals and also the use of these compounds as antithrombotic agents. Also, disclosed are methods of using these inhibitors in their various embodiments as therapeutic agents for disease states characterized by disorders of the blood coagulation process. Further disclosed are compounds useful as intermediates in the preparation of these compounds.
摘要翻译： 本发明涉及在哺乳动物中用作抗血栓形成剂的N-磺酰基精氨酸α-酮酰胺衍生物及其药学上可接受的盐和组合物，以及这些化合物作为抗血栓形成剂的用途。 还公开了在各种实施方案中使用这些抑制剂作为以凝血过程紊乱为特征的疾病状态的治疗剂的方法。 进一步公开的是可用作制备这些化合物的中间体的化合物。
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公开(公告)号：US5886146A
公开(公告)日：1999-03-23
申请号：US459705
申请日：1995-06-02
IPC分类号： A61K38/00 , A61K38/05 , A61K38/55 , A61P7/00 , A61P7/02 , A61P7/04 , C07C279/36 , C07C281/06 , C07C281/10 , C07D207/16 , C07D257/04 , C07K5/06 , C07K5/072 , C07K5/078 , A61K38/06
CPC分类号： C07K5/06113 , C07C279/36 , C07C281/06 , C07C281/10 , C07D207/16 , C07D257/04 , C07K5/06078 , C07K5/06104 , C07K5/06139 , A61K38/00
摘要： This invention relates to peptide aldehyde analogs that inhibit the thrombin or Factor Xa. The compounds are thought useful for preventing or treating conditions in mammal characterized by abnormal thrombosis.
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公开(公告)号：US5708141A
公开(公告)日：1998-01-13
申请号：US249041
申请日：1994-05-24
申请人： Matthew Moyle , David L. Foster , George P. Vlasuk
发明人： Matthew Moyle , David L. Foster , George P. Vlasuk
IPC分类号： A61K38/00 , C07K14/435 , C07K14/535 , C07K2/00 , A61K35/56
CPC分类号： C07K14/535 , C07K14/4354 , A61K38/00
摘要： Compositions enriched for Neutrophil Inhibitory Factor which inhibit neutrophil activity including adhesion to vascular endothelial cells are provided. Such compositions may comprise a glycoprotein isolated from nematodes, particularly of the genus Ancylostoma. These compositions are useful in the therapy of conditions which involve abnormal or undesired inflammatory responses.
摘要翻译： 提供了富含中性粒细胞抑制因子的组合物，其抑制嗜中性粒细胞活性，包括对血管内皮细胞的粘附。 这样的组合物可以包含从线虫特别是Ancylostoma属分离的糖蛋白。 这些组合物可用于治疗涉及异常或不期望的炎性反应的病症。
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公开(公告)号：US5492895A
公开(公告)日：1996-02-20
申请号：US195995
申请日：1994-02-14
IPC分类号： A61K38/00 , A61K38/05 , A61K38/55 , A61P7/00 , A61P7/02 , A61P7/04 , C07C279/36 , C07C281/06 , C07C281/10 , C07D207/16 , C07D257/04 , C07K5/06 , C07K5/072 , C07K5/078 , A61K38/06
CPC分类号： C07K5/06113 , C07C279/36 , C07C281/06 , C07C281/10 , C07D207/16 , C07D257/04 , C07K5/06078 , C07K5/06104 , C07K5/06139 , A61K38/00
摘要： This invention relates to peptide aldehyde analogs that inhibit the thrombin or Factor Xa. The compounds are thought useful for preventing or treating conditions in mammal characterized by abnormal thrombosis.
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公开(公告)号：US5239058A
公开(公告)日：1993-08-24
申请号：US876825
申请日：1992-04-29
CPC分类号： C07K14/811 , A61K38/00
摘要： Proteins which specifically inhibit coagulation Factor Xa. The inhibitors, which do not inhibit Factor VIIa, kallikrein, trypsin, chymotrypsin, thrombin, urokinase, tissue plasminogen activator, plasmin, elastase, Factor XIa or S. aureus V8 protease, are polypeptides of 60 amino acid residues. The inhibitors may be purified from Ornithodoros moubata extract, synthesized, or produced using a recombinant DNA yeast expression system.
摘要翻译： 特异性抑制凝血因子Xa的蛋白质。 不抑制因子VIIa，激肽释放酶，胰蛋白酶，胰凝乳蛋白酶，凝血酶，尿激酶，组织纤溶酶原激活剂，纤溶酶，弹性蛋白酶，因子XIa或金黄色葡萄球菌V8蛋白酶的抑制剂是60个氨基酸残基的多肽。 抑制剂可以从合成的Ornithodoros moubata提取物中纯化，或使用重组DNA酵母表达系统产生。
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