公开(公告)号：US07141561B2

公开(公告)日：2006-11-28

申请号：US10626314

申请日：2003-07-24

申请人： Lothar Schwink ,  Siegfried Stengelin ,  Matthias Gossel ,  Thomas Boehme ,  Gerhard Hessler ,  Gerard Rosse ,  Armin Walser

发明人： Lothar Schwink ,  Siegfried Stengelin ,  Matthias Gossel ,  Thomas Boehme ,  Gerhard Hessler ,  Gerard Rosse ,  Armin Walser

IPC分类号： A61K31/397 ,  A61K31/415 ,  C07D417/10 ,  C07D401/10 ,  C07D233/02

CPC分类号： C07D233/92 ,  C07D209/02 ,  C07D233/32 ,  C07D233/70 ,  C07D233/74 ,  C07D233/94 ,  C07D243/04 ,  C07D249/12 ,  C07D401/12 ,  C07D403/12 ,  C07D405/10 ,  C07D405/12 ,  C07D409/10 ,  C07D409/12 ,  C07D417/12 ,  C07D487/08 ,  C07D491/10

摘要： This invention discloses and claims diary heterocycles of formula (I) and their pharmaceutically acceptable salts, pharmaceutical compositions thereof, and methods of using said compounds of formula (I) for the treatment or prevention of excessive weight or obesity, and for treatment of Type II diabetes, arteriosclerosis, high blood pressure, depression, anxiety, anxiety neuroses, and schizophrenia. Methods for treatment of excessive weight or obesity and for treatment of Type II diabetes with a mixture of a compound of formula I and antiobesity agents or appetite-regulating active ingredients, or with a mixture of a compound of formula I and antidiabetics or hypoglycemic active ingredients are also disclosed and claimed.

摘要翻译： 本发明公开并要求式（I）的日记杂环及其药学上可接受的盐，其药物组合物，以及使用式（I）化合物治疗或预防过度体重或肥胖以及用于治疗II型 糖尿病，动脉硬化，高血压，抑郁，焦虑，焦虑神经症和精神分裂症。 用于治疗过度体重或肥胖以及用式I化合物与抗肥胖剂或食欲调节活性成分的混合物或与式I化合物与抗糖尿病药或降血糖活性成分的混合物治疗II型糖尿病的方法 也被公开和要求保护。

公开(公告)号：US07635698B2

公开(公告)日：2009-12-22

申请号：US11320298

申请日：2005-12-28

申请人： Gerard Rosse ,  Linli Wei ,  Kenneth G. Carson

发明人： Gerard Rosse ,  Linli Wei ,  Kenneth G. Carson

IPC分类号： A61K31/497 ,  C07D295/00 ,  C07D241/04

CPC分类号： C07D207/14 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/06 ,  C07D405/12 ,  C07D409/06 ,  C07D409/12 ,  C07D487/08 ,  C07D491/10

摘要： The present invention relates to compounds useful as Chemokine Receptor antagonists. Compounds of general formula I are provided: or pharmaceutically acceptable salts thereof. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compounds and compositions for the inhibition of Chemokine Receptors and also for the treatment of various diseases, conditions, or disorders, including acute or chronic inflammatory disease, cancer, and osteolytic bone disorders.

摘要翻译： 本发明涉及可用作趋化因子受体拮抗剂的化合物。 提供通式I的化合物：或其药学上可接受的盐。 本发明还提供包含所述化合物的药学上可接受的组合物以及使用化合物和组合物抑制趋化因子受体的方法，还用于治疗各种疾病，病症或病症，包括急性或慢性炎性疾病，癌症和溶骨性骨 疾病

公开(公告)号：US20060189628A1

公开(公告)日：2006-08-24

申请号：US11320298

申请日：2005-12-28

申请人： Gerard Rosse ,  Linli Wei ,  Kenneth Carson

发明人： Gerard Rosse ,  Linli Wei ,  Kenneth Carson

IPC分类号： A61K31/496 ,  A61K31/4545 ,  C07D403/14 ,  C07D401/14

CPC分类号： C07D207/14 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/06 ,  C07D405/12 ,  C07D409/06 ,  C07D409/12 ,  C07D487/08 ,  C07D491/10

摘要： The present invention relates to compounds useful as Chemokine Receptor antagonists. Compounds of general formula I are provided: or pharmaceutically acceptable salts thereof. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compounds and compositions for the inhibition of Chemokine Receptors and also for the treatment of various diseases, conditions, or disorders, including acute or chronic inflammatory disease, cancer, and osteolytic bone disorders.

公开(公告)号：US08399455B2

公开(公告)日：2013-03-19

申请号：US12577853

申请日：2009-10-13

申请人： Gerard Rosse ,  Linli Wei ,  Kenneth G. Carson

发明人： Gerard Rosse ,  Linli Wei ,  Kenneth G. Carson

IPC分类号： A61K31/55 ,  C07D243/08

CPC分类号： C07D207/14 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/06 ,  C07D405/12 ,  C07D409/06 ,  C07D409/12 ,  C07D487/08 ,  C07D491/10

摘要： The present invention relates to compounds useful as Chemokine Receptor antagonists. Compounds of general formula I are provided: or pharmaceutically acceptable salts thereof. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compounds and compositions for the inhibition of Chemokine Receptors and also for the treatment of various diseases, conditions, or disorders, including acute or chronic inflammatory disease, cancer, and osteolytic bone disorders.

公开(公告)号：US20100234356A1

公开(公告)日：2010-09-16

申请号：US12577853

申请日：2009-10-13

申请人： Gerard Rosse ,  Linli Wei ,  Kenneth G. Carson

发明人： Gerard Rosse ,  Linli Wei ,  Kenneth G. Carson

IPC分类号： A61K31/551 ,  C07D403/04 ,  A61K31/454 ,  C07D401/14 ,  A61K31/496 ,  C07D243/08 ,  A61P9/10 ,  A61P37/06 ,  A61P19/02 ,  A61P11/06 ,  A61P17/06 ,  A61P3/10 ,  C07D403/14

CPC分类号： C07D207/14 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/06 ,  C07D405/12 ,  C07D409/06 ,  C07D409/12 ,  C07D487/08 ,  C07D491/10

摘要： The present invention relates to compounds useful as Chemokine Receptor antagonists. Compounds of general formula I are provided: or pharmaceutically acceptable salts thereof. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compounds and compositions for the inhibition of Chemokine Receptors and also for the treatment of various diseases, conditions, or disorders, including acute or chronic inflammatory disease, cancer, and osteolytic bone disorders.

摘要翻译： 本发明涉及可用作趋化因子受体拮抗剂的化合物。 提供通式I的化合物：或其药学上可接受的盐。 本发明还提供包含所述化合物的药学上可接受的组合物以及使用化合物和组合物抑制趋化因子受体的方法，还用于治疗各种疾病，病症或病症，包括急性或慢性炎性疾病，癌症和溶骨性骨 疾病