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公开(公告)号：US09155700B2
公开(公告)日：2015-10-13
申请号：US13332756
申请日：2011-12-21
CPC分类号： A61K9/10 , A61K9/0078 , A61L2/0017
摘要： Process for preparing sterile suspensions for inhalation comprising an active ingredient insoluble in water and wherein at least 80% of the particles of said active ingredient have a diameter between 3 and 5 μm, comprising the following stages: dissolving the active ingredient in the minimum quantity of an alcoholic solvent, optionally in the presence of a polyol and adding at least one surfactant, filtering the solution obtained in the previous stage through a sterilizing filter, adding the solution from stage (b) to sterile water under sonication to directly obtain a suspension wherein the particles have a reduced diameter.
摘要翻译： 用于制备用于吸入的无菌悬浮液的方法，其包含不溶于水的活性成分，并且其中所述活性成分的至少80％的颗粒具有3至5μm的直径，包括以下阶段：将活性成分溶解在最小量 醇溶剂，任选在多元醇存在下，并添加至少一种表面活性剂，通过灭菌过滤器过滤前一阶段获得的溶液，将超声处理阶段（b）的溶液加入到无菌水中直接获得悬浮液，其中 颗粒具有减小的直径。
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公开(公告)号：US4995385A
公开(公告)日：1991-02-26
申请号：US483744
申请日：1990-02-23
申请人： Luigi Valentini , Giancarlo Ceschel
发明人： Luigi Valentini , Giancarlo Ceschel
IPC分类号： A61M15/00
CPC分类号： A61M15/0028 , A61M15/0041 , A61M2202/064
摘要： An inhaler (10) for administering medicaments in finely divided form contained in capsules comprises a nebulization chamber (42) and a device (16) for piercing the capsule. That end surface of the nebulization chamber containing the holes (48, 49, 50) for the discharge of air laden with the finely divided medicament is shaped such that the capsule, when resting on it, does not impede air passage through any of the discharge holes. The nebulization chamber, at least in that part thereof closest to said discharge holes, tapers towards that end surface of the chamber comprising the discharge holes.
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3.发明授权Nor- and homo- bile acids derivatives as absorption enhancers for medicaments 失效非 - 和均酸衍生物作为药物的吸收促进剂
公开(公告)号：US5656277A
公开(公告)日：1997-08-12
申请号：US360833
申请日：1994-12-28
申请人： Fabio Berlati , Giancarlo Ceschel , Aldo Roda , Enrico Roda , Celestino Ronchi
发明人： Fabio Berlati , Giancarlo Ceschel , Aldo Roda , Enrico Roda , Celestino Ronchi
CPC分类号： A61K47/28
摘要： The use of nor- and homo-bile acids derivatives as absorption enhancers for medicaments is described. Said derivatives show the advantage of improving the absorption of medicaments through mucosae without being metabolized by the intestinal flora, thus allowing a fast excretion. Moreover, the derivatives of the invention have a negligible toxicity.
摘要翻译： PCT No.PCT / EP93 / 01508 Sec。 371日期1994年12月28日第 102（e）日期1994年12月28日PCT提交1993年6月15日PCT公布。 出版物WO94 / 00155 日期1994年1月6日描述了使用正和胆汁酸衍生物作为药物的吸收促进剂。 所述衍生物显示出通过粘膜改善药物吸收而不被肠道菌群代谢的优点，从而允许快速排泄。 此外，本发明的衍生物具有可忽略的毒性。
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4.发明授权Liquid pharmaceutical composition for nasal administration containing a polypeptide as active ingredient 失效用于鼻内给药的液体药物组合物，其含有多肽作为活性成分
公开(公告)号：US5124315A
公开(公告)日：1992-06-23
申请号：US716390
申请日：1991-06-17
CPC分类号： A61K9/0031 , A61K38/23 , A61K47/12 , A61K9/0043 , A61K9/4858 , Y10S514/80 , Y10S514/808
摘要： A liquid composition for nasal administration of polypeptide/s containing ammonium tartrate and a buffer together with optional adiuvants.
摘要翻译： 用于鼻内给药含有酒石酸铵和缓冲液的多肽/液体组合物以及任选的附加物。
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公开(公告)号：US20120087957A1
公开(公告)日：2012-04-12
申请号：US13332756
申请日：2011-12-21
IPC分类号： A61K9/10 , A61P11/06 , A61K31/137 , A61P29/00 , A61K31/573 , A61K31/58
CPC分类号： A61K9/10 , A61K9/0078 , A61L2/0017
摘要： Process for preparing sterile suspensions for inhalation comprising an active ingredient insoluble in water and wherein at least 80% of the particles of said active ingredient have a diameter between 3 and 5 μm, comprising the following stages: dissolving the active ingredient in the minimum quantity of an alcoholic solvent, optionally in the presence of a polyol and adding at least one surfactant, filtering the solution obtained in the previous stage through a sterilizing filter, adding the solution from stage (b) to sterile water under sonication to directly obtain a suspension wherein the particles have a reduced diameter.
摘要翻译： 用于制备用于吸入的无菌悬浮液的方法，其包含不溶于水的活性成分，并且其中所述活性成分的至少80％的颗粒具有3至5μm的直径，包括以下阶段：将活性成分溶解在最小量 醇溶剂，任选在多元醇存在下，并添加至少一种表面活性剂，通过灭菌过滤器过滤前一阶段获得的溶液，将超声处理阶段（b）的溶液加入到无菌水中直接获得悬浮液，其中 颗粒具有减小的直径。
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6.发明申请公开(公告)号：US20050089476A1
公开(公告)日：2005-04-28
申请号：US10971231
申请日：2004-10-22
CPC分类号： A61K9/10 , A61K9/0078 , A61L2/0017
摘要： Process for preparing sterile suspensions for inhalation comprising an active ingredient insoluble in water and wherein at least 80% of the particles of said active ingredient have a diameter between 3 and 5 μm, comprising the following stages: dissolving the active ingredient in the minimum quantity of an alcoholic solvent, optionally in the presence of a polyol and adding at least one surfactant, filtering the solution obtained in the previous stage through a sterilizing filter, adding the solution from stage (b) to sterile water under sonication to directly obtain a suspension wherein the particles have a reduced diameter.
摘要翻译： 用于制备用于吸入的无菌悬浮液的方法，其包含不溶于水的活性成分，并且其中所述活性成分的至少80％的颗粒具有3至5μm的直径，包括以下阶段：将活性成分溶解在最小量 醇溶剂，任选在多元醇存在下，并添加至少一种表面活性剂，通过灭菌过滤器过滤前一阶段获得的溶液，将超声处理阶段（b）的溶液加入到无菌水中直接获得悬浮液，其中 颗粒具有减小的直径。
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公开(公告)号：US5152284A
公开(公告)日：1992-10-06
申请号：US707226
申请日：1991-05-24
申请人： Luigi Valentini , Giancarlo Ceschel
发明人： Luigi Valentini , Giancarlo Ceschel
IPC分类号： A61M15/00
CPC分类号： A61M15/0028 , A61M15/0033 , A61M2202/064
摘要： A disposable inhaler (10; 50; 60) for administering medicaments in finely divided form contained in capsules (22) comprises a body (12) enclosing a nebulization chamber (20), the capsule being inserted into the nebulization chamber during assembly of the component parts of the inhaler. The inhaler does not comprise a device for piercing the capsule. This latter is pierced before its insertion into the inhaler. A cup is provided for preventing escape of the finely divided medicament through the capsule holes (42, 44) until the moment in which the inhaler is used.
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