公开(公告)号：US20070071676A1

公开(公告)日：2007-03-29

申请号：US11534847

申请日：2006-09-25

申请人： Gilbert Gonzales ,  Dale DeVore ,  Suresh Srivastava

发明人： Gilbert Gonzales ,  Dale DeVore ,  Suresh Srivastava

IPC分类号： A61K51/00

CPC分类号： A61K51/1018 ,  A61K51/1093 ,  A61K2121/00

摘要： Compositions and methods for treating and imaging vulnerable plaque and other inflammatory conditions in a patient rely on the delivery of conversion electron-emitting sources and other radionuclides to regions of exposed collagen in the vasculature or other body lumens. The conversion electron-emitting sources or other radionuclides are coupled to a collagen-binding substance and administered to the vasculature or other body lumen to permit binding for imaging and/or therapeutic purposes.

摘要翻译： 用于治疗和成像患者易损斑块和其他炎性病症的组合物和方法依赖于将转化的电子发射源和其它放射性核素递送到脉管系统或其他体腔内暴露胶原的区域。 转换电子发射源或其他放射性核素与胶原结合物质偶联，并施用于脉管系统或其他体腔，以允许用于成像和/或治疗目的的结合。

公开(公告)号：US20060235504A1

公开(公告)日：2006-10-19

申请号：US11351435

申请日：2006-02-09

申请人： Gilbert Gonzales

发明人： Gilbert Gonzales

IPC分类号： A61F2/90

CPC分类号： A61F2/915 ,  A61F2/91 ,  A61F2002/91533 ,  A61F2002/91558 ,  A61F2230/0054 ,  A61F2250/0068 ,  A61N5/1002

摘要： A luminal implant comprises a conversion electron emitting source present on an expandable scaffold. Implant may be positioned within a blood vessel or other luminal site at risk of hyperplasia or neoplasia. The conversion electrons emitted by the source will inhibit hyperplasia or neoplasia.

摘要翻译： 管腔植入物包含存在于可扩展支架上的转化电子发射源。 植入物可能位于血管或其他具有增生或瘤形成风险的腔内部位。 由源发射的转化电子将抑制增生或瘤形成。

公开(公告)号：US20060025839A1

公开(公告)日：2006-02-02

申请号：US11230828

申请日：2005-09-20

申请人： Gilbert Gonzales

发明人： Gilbert Gonzales

IPC分类号： A61F7/00 ,  A61F7/12

CPC分类号： A61F7/123 ,  A61F2007/0028 ,  A61F2007/0054

摘要： A system and method for cooling and warming the central nervous system of a patient comprises a delivery tube with one of the ends couplable to a supply of fluid. A head structure is coupled to the other end of the delivery tube and cooling or warming fluid is directed through the tube to the head structure. The head structure is configured to be placed within the rectal cavity of a patient such that either a contact surface on the head structure or the fluid itself directly contacts a portion of the rectal mucosal membrane. A means for reversing the vertebral venous flow of blood through Batson's plexus supplies cooled or warmed blood directly to the vertebral structures. Unique methods of utilizing the system to selectively cool and warm the central nervous system structures of a patient are set forth herein.

摘要翻译： 用于冷却和加热患者的中枢神经系统的系统和方法包括一个输送管，其中一个端部可连接到流体供应。 头部结构联接到输送管的另一端，并且冷却或加温流体通过管被引导到头部结构。 头部结构被配置为放置在患者的直肠腔内，使得头部结构上的接触表面或流体本身直接接触直肠粘膜的一部分。 通过Batson's丛将血液的脊椎静脉血流逆转，将冷却或加热的血液直接供给脊椎结构的手段。 本文阐述了利用系统选择性地冷却和温暖患者的中枢神经系统结构的独特方法。

公开(公告)号：US20050101936A1

公开(公告)日：2005-05-12

申请号：US10702893

申请日：2003-11-06

申请人： Gilbert Gonzales ,  Paolo Manfredi

发明人： Gilbert Gonzales ,  Paolo Manfredi

IPC分类号： A61J3/07 ,  A61J3/08 ,  A61J7/00 ,  A61K9/00 ,  A61K9/02 ,  A61M31/00

CPC分类号： A61J7/003 ,  A61J3/07 ,  A61J3/08 ,  A61J7/0053 ,  A61K9/0031 ,  A61K9/0056 ,  A61K9/006 ,  A61K9/02 ,  A61K9/025

摘要： A pharmaceutical composition for administration to a patient body. The composition includes a physiologically-acceptable formulation including at least one active pharmaceutical ingredient, wherein said physiologically-acceptable formulation including said at least one active pharmaceutical ingredient is provided in a delivery form, said delivery form being administrable to a patient body through a plurality of administration routes, which include the oral and rectal routes.

摘要翻译： 一种用于给予患者体内的药物组合物。 组合物包括生理上可接受的制剂，其包含至少一种活性药物成分，其中包含所述至少一种活性药物成分的所述生理学上可接受的制剂以递送形式提供，所述递送形式可通过多个 行政路线，包括口头和直肠路线。

公开(公告)号：US20050021113A1

公开(公告)日：2005-01-27

申请号：US10912484

申请日：2004-08-05

申请人： Gilbert Gonzales

发明人： Gilbert Gonzales

IPC分类号： A61M31/00 ,  A61F7/00 ,  A61F7/02 ,  A61F7/12

CPC分类号： A61F7/123 ,  A61F2007/0028 ,  A61F2007/0054

摘要： A system and method for cooling and warming the central nervous system of a patient comprises a delivery tube with one of the ends couplable to a supply of fluid. A head structure is coupled to the other end of the delivery tube and cooling or warming fluid is directed through the tube to the head structure. The head structure is configured to be placed within the rectal cavity of a patient such that either a contact surface on the head structure or the fluid itself directly contacts a portion of the rectal mucosal membrane. A means for reversing the vertebral venous flow of blood through Batson's plexus supplies cooled or warmed blood directly to the vertebral structures. Unique methods of utilizing the system to selectively cool and warm the central nervous system structures of a patient are set forth herein.

摘要翻译： 用于冷却和加热患者的中枢神经系统的系统和方法包括一个输送管，其中一个端部可连接到流体供应。 头部结构联接到输送管的另一端，并且冷却或加温流体通过管被引导到头部结构。 头部结构被配置为放置在患者的直肠腔内，使得头部结构上的接触表面或流体本身直接接触直肠粘膜的一部分。 通过Batson's丛将血液的脊椎静脉血流逆转，将冷却或加热的血液直接供给脊椎结构的手段。 本文阐述了利用系统选择性地冷却和温暖患者的中枢神经系统结构的独特方法。

公开(公告)号：US20210324619A1

公开(公告)日：2021-10-21

申请号：US16852494

申请日：2020-04-19

申请人： Gilbert Gonzales

发明人： Gilbert Gonzales

IPC分类号： E03D9/03

摘要： A toilet deodorant container, including a main body to store a toilet deodorant upon an interior surface therein, at least one water aperture disposed on at least a portion of the main body to facilitate movement of water therethrough, and a hook assembly disposed on at least a portion of a side of the main body to connect via an outer surface of the hook assembly to a toilet bowl to suspend the main body into the toilet bowl.

公开(公告)号：US20060235312A1

公开(公告)日：2006-10-19

申请号：US11380344

申请日：2006-04-26

申请人： Gilbert Gonzales

发明人： Gilbert Gonzales

IPC分类号： A61B5/02

CPC分类号： A61K49/0004

摘要： A method and combination including a visual marker for monitoring a patient to determine compliance with a medication regimen. An orally administrable medication composition is provided in combination with a visual marker. When the combination is orally ingested, the marker causes a coloration or discoloration of the oral and/or pharyngeal cavity of a subject. By visually observing the oral and/or pharyngeal cavity of the subject, one can determine whether medication has been ingested based upon the presence or absence of the coloration/discoloration.

摘要翻译： 一种包括用于监测患者以确定对药物方案的依从性的视觉标记物的方法和组合。 与视觉标记组合提供可口服给药的药物组合物。 当组合口服摄取时，标记物引起受试者的口腔和/或咽腔的着色或变色。 通过目视观察受试者的口腔和/或咽腔，可以根据是否存在着色/变色来确定药物是否已被摄取。

公开(公告)号：US20050222539A1

公开(公告)日：2005-10-06

申请号：US10817224

申请日：2004-04-02

申请人： Gilbert Gonzales ,  Matthew Huddleston ,  Kenneth Hughes

发明人： Gilbert Gonzales ,  Matthew Huddleston ,  Kenneth Hughes

IPC分类号： A61M5/00 ,  A61M5/20 ,  A61M5/31 ,  A61M5/32

CPC分类号： A61M5/2033 ,  A61M5/3129 ,  A61M5/3157 ,  A61M5/326 ,  A61M5/3271 ,  A61M2005/2013 ,  A61M2005/206 ,  A61M2005/2073 ,  A61M2205/583

摘要： An injector device comprising a body containing a syringe with a needle and plunger, a drive spring coupled with the syringe and operable, when released, to drive the syringe forward to inject the needle and subsequently to dispense a dosage from the syringe, a housing containing the body and drive spring, and a release apparatus coupled with the housing. The drive spring is initially locked in an unreleased position, and the body is slidable with respect to the housing and configured for sliding upward in the housing when the injector device is pressed down at an injection site to engage the release apparatus and release the drive spring for delivering a dosage.

摘要翻译： 一种注射器装置，其包括具有针和柱塞的注射器的主体，与注射器联接的驱动弹簧，当释放时可驱动注射器向前注射针头，随后从注射器分配剂量， 主体和驱动弹簧以及与壳体联接的释放装置。 驱动弹簧最初被锁定在未释放位置，并且主体可相对于壳体滑动并且构造成当喷射器装置在注射位置处向下滑动以接合释放装置并释放驱动弹簧 用于递送剂量。

公开(公告)号：US20050173231A1

公开(公告)日：2005-08-11

申请号：US11034319

申请日：2005-01-12

申请人： Gilbert Gonzales

发明人： Gilbert Gonzales

IPC分类号： G08B6/00 ,  G09B21/00 ,  H01H9/26

CPC分类号： G09B21/003 ,  G08B6/00

摘要： A tactile communications device includes a two dimensional surface configured to be positioned in contact with a wearer for tactual stimulation. A plurality of actuators are positioned on the surface and arranged in a generally planar array. Various of the actuators are operable for being sequentially activated, line-by-line, to produce a non-veridical perception of a three dimensional surface.

摘要翻译： 触觉通信装置包括被配置为定位成与佩戴者接触以进行触觉刺激的二维表面。 多个致动器定位在表面上并且布置成大致平面的阵列。 各种致动器可操作以逐行地依次激活，以产生三维表面的非实质感知。

公开(公告)号：US20050136112A1

公开(公告)日：2005-06-23

申请号：US10741873

申请日：2003-12-19

申请人： Gilbert Gonzales ,  Kenneth Hughes ,  Sofia Gonzales

发明人： Gilbert Gonzales ,  Kenneth Hughes ,  Sofia Gonzales

IPC分类号： A61K9/00 ,  A61K9/20 ,  A61K9/70 ,  A61K9/24 ,  A61K9/14

CPC分类号： A61K9/0095 ,  A61K9/0056 ,  A61K9/006 ,  A61K9/2086

摘要： Oral medicament delivery system comprising a pharmaceutical composition comprising a flexible matrix, said matrix formed of a plurality of fibers comprising a collagen-based carrier and a medicament, the composition orally dissolvable to deliver a unit dose of the medicament to a patient. The flexible composition can be dose titrated and co-administered with a second pharmaceutical formulation.

摘要翻译： 口服药物递送系统，其包含药物组合物，其包含柔性基质，所述基质由包含基于胶原的载体的多种纤维和药物形成，所述组合物可口服溶解以将单位剂量的药物递送至患者。 柔性组合物可以被剂量滴定并与第二种药物制剂共同施用。