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25 条记录 (耗时 0.019 秒)

    Cyclohexyl(alkyl)propanolamines, preparation method and pharmaceutical compositions containing same
    1.
    发明授权
    Cyclohexyl(alkyl)propanolamines, preparation method and pharmaceutical compositions containing same 有权

    公开(公告)号：US07419974B2

    公开(公告)日：2008-09-02

    申请号：US11464537

    申请日：2006-08-15

    申请人： Philippe R. Bovy ,  Roberto Cecchi ,  Gilles Courtemanche ,  Tiziano Croci ,  Ambrogio Oliva ,  Nunzia Viviani

    发明人： Philippe R. Bovy ,  Roberto Cecchi ,  Gilles Courtemanche ,  Tiziano Croci ,  Ambrogio Oliva ,  Nunzia Viviani

    IPC分类号： A61K31/216 ,  A61K31/423 ,  A61K31/553 ,  A61K31/401

    CPC分类号： C07C311/21 ,  C07C229/46 ,  C07C311/08 ,  C07C317/22 ,  C07C2601/14

    摘要： The present invention relates to the compounds of formula (I): in which A is a group of formula (a) or (b) in which R represents a hydrogen or halogen atom, an —S(O)z(C1-C4)alkyl group, an —NHSO2(C1-C4)alkyl group, an —SO2NH(C1-C4)alkyl group, an —NHSO2phenyl-(C1-C4)alkyl group or an —NHSO2phenyl group, said phenyl possibly being substituted with a halogen atom, with a (C1-C4)alkyl group or with a (C1-C4)alkoxy group; R1 represents a hydrogen atom or a (C1-C4)alkyl group, a —CO(C1-C4)alkyl group, a phenyl-(C1-C4)alkyl group or a —COphenyl group, said phenyl also possibly being substituted with a halogen atom or with a (C1-C4)alkoxy group; R2 is a hydrogen atom or an —SO2(C1-C4)alkyl group, an —SO2phenyl-(C1-C4)alkyl group or an —SO2phenyl group; X completes a ring of 5 to 8 atoms, said ring being saturated or unsaturated, possibly being substituted with one or two (C1-C4)alkyl groups and bearing one or two carbonyl groups; n, m and z are, independently, 0, 1 or 2; R3 represents a hydrogen or halogen atom, a (C1-C6)alkyl group, a (C1-C4)alkoxy group, a —COO(C1-C4)alkyl group, a —CO(C1-C4)alkyl group, an —NHSO2(C1-C4)alkyl group, an —NHSO2phenyl-(C1-C4)alkyl groups, —NO2, —CN, —CONR4R5, —COOH, or a 4,5-dihydro-1,3-oxazol-2-yl or 4,4-dimethyl-4,5-dihydro-1,3-oxazol-2-yl group; R4 and R5 represent, independently, a hydrogen atom, a phenyl, a (C1-C4)alkyl group or a phenyl-(C1-C4)alkyl group or R4 and R5 with the nitrogen atom to which they are attached, may form a ring of 5 to 7 atoms in total; and to the salts or solvates thereof, to the pharmaceutical compositions containing them, to a process for the preparation thereof and to intermediates in this process.

    Cyclohexyl(alkyl)propanolamines, Preparation Method and Pharmaceutical Compositions Containing Same
    3.
    发明申请
    Cyclohexyl(alkyl)propanolamines, Preparation Method and Pharmaceutical Compositions Containing Same 有权

    公开(公告)号：US20070015745A1

    公开(公告)日：2007-01-18

    申请号：US11464537

    申请日：2006-08-15

    申请人： Philippe BOVY ,  Roberto CECCHI ,  Gilles COURTEMANCHE ,  Tiziano CROCI ,  Ambrogio OLIVA ,  Nunzia VIVIANI

    发明人： Philippe BOVY ,  Roberto CECCHI ,  Gilles COURTEMANCHE ,  Tiziano CROCI ,  Ambrogio OLIVA ,  Nunzia VIVIANI

    IPC分类号： A61K31/553 ,  A61K31/538 ,  A61K31/423 ,  A61K31/138 ,  C07D263/52

    CPC分类号： C07C311/21 ,  C07C229/46 ,  C07C311/08 ,  C07C317/22 ,  C07C2601/14

    摘要： The present invention relates to the compounds of formula (I): in which A is a group of formula (a) or (b) in which R represents a hydrogen or halogen atom, an —S(O)z(C1-C4)alkyl group, an —NHSO2(C1-C4)alkyl group, an —SO2NH(C1-C4)alkyl group, an —NHSO2phenyl-(C1-C4)alkyl group or an —NHSO2phenyl group, said phenyl possibly being substituted with a halogen atom, with a (C1-C4)alkyl group or with a (C1-C4)alkoxy group; R1 represents a hydrogen atom or a (C1-C4)alkyl group, a —CO(C1-C4)alkyl group, a phenyl-(C1-C4)alkyl group or a —CO—phenyl group, said phenyl also possibly being substituted with a halogen atom or with a (C1-C4)alkoxy group; R2 is a hydrogen atom or an —SO2(C1-C4)alkyl group, an —SO2phenyl-(C1-C4)alkyl group or an —SO2phenyl group; X completes a ring of 5 to 8 atoms, said ring being saturated or unsaturated, possibly being substituted with one or two (C1-C4)alkyl groups and bearing one or two carbonyl groups; n, m and z are, independently, 0, 1 or 2; R3 represents a hydrogen or halogen atom, a (C1-C6)alkyl group, a (C1-C4)alkoxy group, a —COO(C1-C4)alkyl group, a —CO(C1-C4)alkyl group, an —NHSO2(C1-C4)alkyl group, an —NHSO2phenyl-(C1-C4)alkyl groups, —NO2, —CN, —CONR4R5, —COOH, or a 4,5-dihydro-1,3-oxazol-2-yl or 4,4-dimethyl-4,5-dihydro-1,3-oxazol-2-yl group; R4 and R5 represent, independently, a hydrogen atom, a phenyl, a (C1-C4)alkyl group or a phenyl-(C1-C4)alkyl group or R4 and R5 with the nitrogen atom to which they are attached, may form a ring of 5 to 7 atoms in total; and to the salts or solvates thereof, to the pharmaceutical compositions containing them, to a process for the preparation thereof and to intermediates in this process.

    Method for producing glass sheets using flotation
    4.
    发明授权
    Method for producing glass sheets using flotation 失效
    使用浮选制造玻璃板的方法

    公开(公告)号：US6089043A

    公开(公告)日：2000-07-18

    申请号：US952215

    申请日：1998-04-09

    申请人： Gilles Courtemanche ,  Michel Coquillon

    发明人： Gilles Courtemanche ,  Michel Coquillon

    IPC分类号： C03B18/06 ,  C03B13/00 ,  C03B18/00 ,  C03B18/02

    CPC分类号： C03B18/06

    摘要： The present invention relates to a process for the manufacture of glass sheets, according to which molten glass is poured into a liquid support which is denser than the glass to form a glass strip. The glass strip is drawn and is accompanied in its movement using a continuous and flexible guiding element made of a solid material capable of adhering to the molten glass, the elements being brought into contact with the side edges of the strip. The product (P) of the value (s) of the speed of the strip and of the value (t) of its final thickness is less than 2.5.times.10.sup.-4 m.sup.2 s.sup.-1. The process makes it possible to obtain thin glass sheets exhibiting a constant thickness and a satisfactory optical quality.

    摘要翻译： PCT No.PCT / FR97 / 00555 Sec。 371日期：1998年4月9日 102（e）1998年4月9日PCT 1997年3月27日PCT公布。 公开号WO97 / 37945 PCT 日期1997年10月16日本发明涉及一种玻璃板的制造方法，根据该方法，将熔融玻璃倒入比玻璃更密的液体载体中以形成玻璃带。 玻璃带被拉伸并伴随其运动，使用由能够粘附到熔融玻璃上的固体材料制成的连续且柔性的引导元件，元件与条的侧边缘接触。 带材的速度值和其最终厚度的值（t）的乘积（P）小于2.5×10 -4 m 2·s -1。 该方法可以获得具有恒定厚度和令人满意的光学质量的薄玻璃板。

    Cyclohexyl(alkyl)propanolamines, preparation method and pharmaceutical compositions containing same
    5.
    发明授权
    Cyclohexyl(alkyl)propanolamines, preparation method and pharmaceutical compositions containing same 有权

    公开(公告)号：US07718646B2

    公开(公告)日：2010-05-18

    申请号：US12144843

    申请日：2008-06-24

    申请人： Philippe R. Bovy ,  Roberto Cecchi ,  Gilles Courtemanche ,  Tiziano Croci ,  Ambrogio Oliva ,  Nunzia Viviani

    发明人： Philippe R. Bovy ,  Roberto Cecchi ,  Gilles Courtemanche ,  Tiziano Croci ,  Ambrogio Oliva ,  Nunzia Viviani

    IPC分类号： A61K31/553 ,  C07D263/54 ,  C07D267/02 ,  C07C311/01

    CPC分类号： C07C311/21 ,  C07C229/46 ,  C07C311/08 ,  C07C317/22 ,  C07C2601/14

    摘要： The present invention relates to the compounds of formula (I): in which A is a group of formula (a) or (b) in which R represents a hydrogen or halogen atom, an —S(O)z(C1-C4)alkyl group, an —NHSO2(C1-C4)alkyl group, an —SO2NH(C1-C4)alkyl group, an —NHSO2phenyl-(C1-C4)alkyl group or an —NHSO2phenyl group, said phenyl possibly being substituted with a halogen atom, with a (C1-C4)alkyl group or with a (C1-C4)alkoxy group; R1 represents a hydrogen atom or a (C1-C4)alkyl group, a —CO(C1-C4)alkyl group, a phenyl-(C1-C4)alkyl group or a —COphenyl group, said phenyl also possibly being substituted with a halogen atom or with a (C1-C4)alkoxy group; R2 is a hydrogen atom or an —SO2(C1-C4)alkyl group, an —SO2phenyl-(C1-C4)alkyl group or an —SO2phenyl group; X completes a ring of 5 to 8 atoms, said ring being saturated or unsaturated, possibly being substituted with one or two (C1-C4)alkyl groups and bearing one or two carbonyl groups; n, m and z are, independently, 0, 1 or 2; R3 represents a hydrogen or halogen atom, a (C1-C6)alkyl group, a (C1-C4)alkoxy group, a —COO(C1-C4)alkyl group, a —CO(C1-C4)alkyl group, an —NHSO2(C1-C4)alkyl group, an —NHSO2phenyl-(C1-C4)alkyl groups, —NO2, —CN, —CONR4R5, —COOH, or a 4,5-dihydro-1,3-oxazol-2-yl or 4,4-dimethyl-4,5-dihydro-1,3-oxazol-2-yl group; R4 and R5 represent, independently, a hydrogen atom, a phenyl, a (C1-C4)alkyl group or a phenyl-(C1-C4)alkyl group or R4 and R5 with the nitrogen atom to which they are attached, may form a ring of 5 to 7 atoms in total; and to the salts or solvates thereof, to the pharmaceutical compositions containing them, to a process for the preparation thereof and to intermediates in this process.

    Cyclohexyl(alkyl)-propanolamines, preparation method and pharmaceutical compositions containing same
    7.
    发明授权
    Cyclohexyl(alkyl)-propanolamines, preparation method and pharmaceutical compositions containing same 有权

    公开(公告)号：US07388031B2

    公开(公告)日：2008-06-17

    申请号：US10432493

    申请日：2001-11-30

    申请人： Philippe R. Bovy ,  Roberto Cecchi ,  Gilles Courtemanche ,  Tiziano Croci ,  Ambrogio Oliva ,  Nunzia Viviani

    发明人： Philippe R. Bovy ,  Roberto Cecchi ,  Gilles Courtemanche ,  Tiziano Croci ,  Ambrogio Oliva ,  Nunzia Viviani

    IPC分类号： A61K31/18 ,  C07C311/08

    CPC分类号： C07C311/21 ,  C07C229/46 ,  C07C311/08 ,  C07C317/22 ,  C07C2601/14

    摘要： The present invention relates to the compounds of formula (I): in which A is a group of formula (a) or (b) in which R represents a hydrogen or halogen atom, an —S(O)z(C1–C4)alkyl group, an —NHSO2(C1–C4)alkyl group, an —SO2NH(C1–C4)alkyl group, an —NHSO2phenyl-(C1–C4)alkyl group or an —NHSO2phenyl group, said phenyl possibly being substituted with a halogen atom, with a (C1–C4)alkyl group or with a (C1–C4)alkoxy group; R1 represents a hydrogen atom or a (C1–C4)alkyl group, a —CO(C1–C4)alkyl group, a phenyl-(C1–C4)alkyl group or a —COphenyl group, said phenyl also possibly being substituted with a halogen atom or with a (C1–C4)alkoxy group; R2 is a hydrogen atom or an —SO2(C1–C4)alkyl group, an —SO2phenyl-(C1–C4)alkyl group or an —SO2phenyl group; X completes a ring of 5 to 8 atoms, said ring being saturated or unsaturated, possibly being substituted with one or two (C1–C4)alkyl groups and bearing one or two carbonyl groups; n, m and z are, independently, 0, 1 or 2; R3 represents a hydrogen or halogen atom, a (C1–C6)alkyl group, a (C1–C4)alkoxy group, a —COO(C1–C4)alkyl group, a —CO(C1–C4)alkyl group, an —NHSO2(C1–C4)alkyl group, an —NHSO2phenyl-(C1–C4)alkyl groups, —NO2, —CN, —CONR4R5, —COOH, or a 4,5-dihydro-1,3-oxazol-2-yl or 4,4-dimethyl-4,5-dihydro-1,3-oxazol-2-yl group; R4 and R5 represent, independently, a hydrogen atom, a phenyl, a (C1–C4)alkyl group or a phenyl-(C1–C4)alkyl group or R4 and R5 with the nitrogen atom to which they are attached, may form a ring of 5 to 7 atoms in total; and to the salts or solvates thereof, to the pharmaceutical compositions containing them, to a process for the preparation thereof and to intermediates in this process.

    Compositions of silico-sodo-calcic glasses and their applications
    9.
    发明授权
    Compositions of silico-sodo-calcic glasses and their applications 失效
    硅钙石眼镜组合及其应用

    公开(公告)号：US5958812A

    公开(公告)日：1999-09-28

    申请号：US991558

    申请日：1997-12-16

    申请人： Stephanie Koch ,  Didier Jousse ,  Rene Gy ,  Gilles Courtemanche

    发明人： Stephanie Koch ,  Didier Jousse ,  Rene Gy ,  Gilles Courtemanche

    IPC分类号： C03B18/02 ,  C03C3/076 ,  C03C3/085 ,  C03C3/087 ,  C03C3/091 ,  C03C3/093 ,  C03C15/02 ,  C03C21/00 ,  C03C23/00

    CPC分类号： C03C23/007 ,  C03C15/02 ,  C03C21/00 ,  C03C3/076 ,  C03C3/087 ,  C03C3/091 ,  C03C3/093 ,  A47B2200/0094

    摘要： This invention concerns a thermally stable glass composition, which comprises the following constituents in the following proportions by weight:______________________________________ SiO.sub.2 45 to 68% Al.sub.2 O.sub.3 0 to 20% ZrO.sub.2 0 to 20% B.sub.2 O.sub.3 0 to 10% Na.sub.2 O 2 to 12% K.sub.2 O 3.5 to 9% CaO 1 to 13% MgO 0 to 8%______________________________________the sum of the contents of the oxides SiO.sub.2, Al.sub.2 O.sub.3 and ZrO.sub.2 remaining equal to or less than 70%, the sum of the oxides Al.sub.2 O.sub.3 and ZrO.sub.2 being equal to or greater than 2%, the sum of the alkaline oxides Na.sub.2 O and K.sub.2 O being equal to or greater than 8%, said composition comprising, if desired, the oxides BaO and/or SrO in proportions such that:11%.ltoreq.MgO+CaO--BaO+SrO>30%This glass composition may be used for the production of substrates for an emissive screen or for that of a fire-resistant pane.

    摘要翻译： 本发明涉及一种热稳定性玻璃组合物，其包含以下重量比的以下组分： - SiO 2 45至68％-Al 2 O 3 0至20％-ZrO 2 0至20％-B 2 O 3 0至10％Na 2 O 2至12 ％ - K2O 3.5〜9％ - CaO 1〜13％ - MgO 0〜8％ - 氧化物SiO 2，Al 2 O 3和ZrO 2的含量的总和等于或小于70％，氧化物Al 2 O 3和ZrO 2的总和 等于或大于2％，碱性氧化物Na 2 O和K 2 O的总和等于或大于8％，如果需要，所述组合物包含氧化物BaO和/或SrO，其比例使得：11％ = MgO + CaO-BaO + SrO> 30％该玻璃组合物可用于生产用于发射屏幕或耐火玻璃板的基板。