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7 条记录 (耗时 0.024 秒)

    8-(heterocyclylmethyl)quinoline derivatives for treating urinary incontinence
    4.
    发明授权
    8-(heterocyclylmethyl)quinoline derivatives for treating urinary incontinence 失效
    用于治疗尿失禁的8-（杂环基甲基）喹啉衍生物

    公开(公告)号：US06413984B1

    公开(公告)日：2002-07-02

    申请号：US09890526

    申请日：2001-08-01

    申请人： Christophe Philippo ,  Alain Braun ,  Philippe R. Bovy

    发明人： Christophe Philippo ,  Alain Braun ,  Philippe R. Bovy

    IPC分类号： A61K3147

    CPC分类号： C07D401/06 ,  Y10S514/844 ,  Y10S514/873 ,  Y10S514/937 ,  Y10S514/938 ,  Y10S514/939

    摘要： The invention concerns compounds of formula (I) wherein: A represents either a hydrogen atom or a hydroxyl group; B represents a pyrrolidin-2-yl (D) or 2-piperidyl (E), B capable of being substituted by one or two R5 groups; R1 represents a hydrogen atom, a C1-C6 alkyl, a C2-C6 alkenyl, a C1-C2 perfluoroalkyl or a C1-C6 fluoroalkyl group; R2, R3 or R4, independently of one another, represent a hydrogen atom, a C1-C6 alkyl, group or a C2-C6 alkenyl group, or R1 and R2 can together form a C1-C6 alkylene chain, or a C3-C6 alkenylene chain; R5 represents a C1-C6 alkyl group, and R6 represents a hydrogen atom, a C1-C6 alkyl group, a C2-C6 alkenyl group, C3-C6 cycloalkyl, C3-C6 cycloalkenyl or a benzyl. Said compounds have therapeutic applications

    摘要翻译： 本发明涉及式（I）的化合物，其中：A表示氢原子或羟基; B表示可被一个或两个R 5基团取代的吡咯烷-2-基（D）或2-哌啶基（E），B。 R1表示氢原子，C1-C6烷基，C2-C6烯基，C1-C2全氟烷基或C1-C6氟代烷基; R2，R3或R4彼此独立地表示氢原子，C1-C6烷基，基团或C2-C6烯基，或者R1和R2可以一起形成C1-C6亚烷基链，或C3-C6 亚烯基链; R5表示C1-C6烷基，R6表示氢原子，C1-C6烷基，C2-C6烯基，C3-C6环烷基，C3-C6环烯基或苄基。 所述化合物具有治疗应用

    2-arylquinoline derivatives, preparation and therapeutic use thereof
    7.
    发明授权
    2-arylquinoline derivatives, preparation and therapeutic use thereof 失效
    2-芳基喹啉衍生物，其制备和治疗用途

    公开(公告)号：US06617336B1

    公开(公告)日：2003-09-09

    申请号：US10130875

    申请日：2002-05-22

    申请人： Philippe R Bovy ,  Alain Braun ,  Christophe Philippo

    发明人： Philippe R Bovy ,  Alain Braun ,  Christophe Philippo

    IPC分类号： A61K314706

    CPC分类号： C07D401/04 ,  C07D215/12 ,  C07D215/14 ,  C07D409/04

    摘要： Compounds of general formula (I) in which: A represents a hydrogen atom, a hydroxyl, a C1-3 alkoxy group, a hydroxy(C1-6 alkyl) group, a (C1-3 alkoxy)(C1-3 alkyl) group, a thiol, (C1-6 alkyl)sulfanyl or a halogen; B and D represent, independently of one another, a hydrogen atom, a C1-6 alkyl group, a fluoro(C1-6 alkyl) group or a perfluoro(C1-2 alkyl) group or B and D together from an oxo; R1 represents a phenyl, a naphthyl or a heteroaryl comprising 4 or 5 carbon atoms; R2 and R3 represent, independently of one another, a hydrogen atom, a halogen or a C1-6 alkyl group, R4 represents a hydrogen atom, a hydroxyl or a halogen, and R5 and R6 represent, independently of one another, a hydrogen atom, a C1-6 alkyl group, a C2-6 alkenyl group, a C3-6 cycloalkyl group, a C3-6 cycloalkenyl group, a fluoro(C1-6 alkyl) group or a perfluoro(C1-2 alkyl) group or R5 and R6 together form a C2-6 alkylene chain or a C3-6 alkenylene chain, to give, with the nitrogen to which they are attached, a heterocycle, this heterocycle optionally being substituted by a C1-4 alkyl group; and their salts.

    摘要翻译： 通式（I）的化合物，其中：A表示氢原子，羟基，C 1-3烷氧基，羟基（C 1-6烷基），（C 1-3烷氧基）（C 1-3烷基） ，硫醇，（C 1-6烷基）硫烷基或卤素; B和D彼此独立地表示氢原子，C 1-6烷基，氟（C 1-6烷基）或全氟（C 1 -C 6烷基） -2烷基）基团或B和D一起来自氧代; R 1表示苯基，萘基或含有4或5个碳原子的杂芳基; R 2和R 3彼此独立地表示氢原子，卤素或C 1 -6-烷基，R 4表示氢原子，羟基或卤素，R 5和R 6彼此独立地表示氢原子，C 1-6烷基，C 2-6烯基，C 3-6环烷基 基团，C3-6环烯基，氟（C1-6烷基）基团或全氟（C1-2烷基）基团或R5和R6一起形成C 2-6亚烷基链或C 3-6亚烯基链，得到 与它们相连的氮，杂环，t 他的杂环任选被C 1-4烷基取代; 和它们的盐。