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公开(公告)号：US20070292389A1
公开(公告)日：2007-12-20
申请号：US11662487
申请日：2005-09-14
申请人： Giorgio Stassi , Matilde Todaro
发明人： Giorgio Stassi , Matilde Todaro
IPC分类号： A61K39/395 , A61K38/20 , A61P35/00 , C12N5/08
CPC分类号： C12N5/0695 , C12N2500/25 , C12N2501/11 , C12N2501/115 , C12N2501/392 , C12N2501/91
摘要： The invention concerns a method for the purification and amplification in the undifferentiated state of tumoral stem cells form solid tumours which are most resistant to conventional therapies, aiming at devising new tumour markers and therapeutic targets both for early diagnosis and for targeted therapeutic strategies.
摘要翻译： 本发明涉及一种用于纯化和扩增肿瘤干细胞的未分化状态的方法，其形成对常规治疗最具抗性的实体瘤，旨在设计用于早期诊断和靶向治疗策略的新肿瘤标志物和治疗靶标。
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公开(公告)号：US20100297110A1
公开(公告)日：2010-11-25
申请号：US12293781
申请日：2007-03-21
申请人： Thomas Hoeger , Juergen Gamer , Giorgio Stassi , Matilde Todaro
发明人： Thomas Hoeger , Juergen Gamer , Giorgio Stassi , Matilde Todaro
IPC分类号： A61K39/395 , C07K16/24 , A61P35/00
CPC分类号： C07K16/247 , A61K39/3955
摘要： The present invention relates to the use of an antibody or an antigen-binding fragment thereof with specific binding activity for human interleukin-4 for the prevention and/or treatment of cancer.
摘要翻译： 本发明涉及对人白细胞介素-4具有特异性结合活性的抗体或其抗原结合片段用于预防和/或治疗癌症的用途。
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3.发明申请公开(公告)号：US20100099742A1
公开(公告)日：2010-04-22
申请号：US12628055
申请日：2009-11-30
申请人： Giorgio Stassi , Matilde Todaro
发明人： Giorgio Stassi , Matilde Todaro
IPC分类号： A61K48/00 , A61K38/16 , A61K31/7048 , A61K31/7052 , A61K31/353
CPC分类号： A61K45/06 , A61K31/337 , A61K31/704 , A61K31/7105 , A61K31/713 , A61K33/24 , A61K38/1793 , A61K38/19 , A61K38/191 , A61K2039/505 , Y02A50/412 , A61K2300/00
摘要： The invention refers to the use of a cytokine antagonist which modulates the expression and/or the function of a cytokine, particularly a Th2 helper cell cytokine, in a cell and causes the down-regulation of anti-apoptotic proteins in said cell through the cytokine modulation for sensitizing cells for apoptosis. In particular, the cells that can be treated with the cytokine antagonists are drug-resistant cancer cells which fail to undergo apoptosis.
摘要翻译： 本发明涉及在细胞中调节细胞因子（特别是Th2辅助细胞细胞因子）的表达和/或功能的细胞因子拮抗剂的用途，并且通过细胞因子引起所述细胞中抗凋亡蛋白的下调 调节细胞凋亡敏感细胞。 特别地，可以用细胞因子拮抗剂治疗的细胞是不能进行细胞凋亡的耐药性癌细胞。
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公开(公告)号：US07645449B2
公开(公告)日：2010-01-12
申请号：US10544794
申请日：2004-02-09
申请人： Giorgio Stassi , Matilde Todaro
发明人： Giorgio Stassi , Matilde Todaro
IPC分类号： A61K39/395 , C12Q1/68
CPC分类号： A61K45/06 , A61K31/337 , A61K31/704 , A61K31/7105 , A61K31/713 , A61K33/24 , A61K38/1793 , A61K38/19 , A61K38/191 , A61K2039/505 , Y02A50/412 , A61K2300/00
摘要： The invention refers to the use of a cytokine antagonist which modulates the expression and/or the function of a cytokine, particularly a Th2 helper cell cytokine, in a cell and causes the down-regulation of anti-apoptotic proteins in said cell through the cytokine modulation for sensitizing cells for apoptosis. In particular, the cells that can be treated with the cytokine antagonists are drug-resistant cancer cells which fail to undergo apoptosis.
摘要翻译： 本发明涉及在细胞中调节细胞因子（特别是Th2辅助细胞细胞因子）的表达和/或功能的细胞因子拮抗剂的用途，并且通过细胞因子引起所述细胞中抗凋亡蛋白的下调 调节细胞凋亡敏感细胞。 特别地，可以用细胞因子拮抗剂治疗的细胞是不能进行细胞凋亡的耐药性癌细胞。
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公开(公告)号：US20060257401A1
公开(公告)日：2006-11-16
申请号：US10544794
申请日：2004-02-09
申请人： Giorgio Stassi , Maltilde Todaro
发明人： Giorgio Stassi , Maltilde Todaro
IPC分类号： A61K39/395 , A61K38/21 , A61K33/24 , A61K31/7048 , A61K31/704 , A61K31/57
CPC分类号： A61K45/06 , A61K31/337 , A61K31/704 , A61K31/7105 , A61K31/713 , A61K33/24 , A61K38/1793 , A61K38/19 , A61K38/191 , A61K2039/505 , Y02A50/412 , A61K2300/00
摘要： The invention refers to the use of a cytokine antagonist which modulates the expression and/or the function of a cytokine, particularly a Th2 helper cell cytokine, in a cell and causes the down-regulation of anti-apoptotic proteins in said cell through the cytokine modulation for sensitizing cells for apoptosis. In particular, the cells that can be treated with the cytokine antagonists are drug-resistant cancer cells which fail to undergo apoptosis.
摘要翻译： 本发明涉及在细胞中调节细胞因子（特别是Th2辅助细胞细胞因子）的表达和/或功能的细胞因子拮抗剂的用途，并且通过细胞因子引起所述细胞中抗凋亡蛋白的下调 调节细胞凋亡敏感细胞。 特别地，可以用细胞因子拮抗剂治疗的细胞是不能进行细胞凋亡的耐药性癌细胞。
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公开(公告)号：US20090324616A1
公开(公告)日：2009-12-31
申请号：US12306070
申请日：2007-06-21
IPC分类号： A61K39/395 , G01N33/574 , C12Q1/68 , C07K2/00 , C07H21/04 , A61P35/00
CPC分类号： G01N33/57484 , G01N33/6863
摘要： The invention concerns a method for diagnosing a cancer type, whereby the expression of anti-apoptotic cytokines is determined in the tumour cells. The differential diagnosis of the present invention is used to classify tumour disorders and to recommend the required treatment and to monitor the progress and response to the treatment.
摘要翻译： 本发明涉及一种用于诊断癌症类型的方法，由此在肿瘤细胞中测定抗凋亡细胞因子的表达。 本发明的鉴别诊断用于分类肿瘤病症并推荐所需治疗并监测治疗的进展和反应。
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